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    Il4i1 interleukin 4 induced 1 [ Mus musculus (house mouse) ]

    Gene ID: 14204, updated on 18-Sep-2024

    Summary

    Official Symbol
    Il4i1provided by MGI
    Official Full Name
    interleukin 4 induced 1provided by MGI
    Primary source
    MGI:MGI:109552
    See related
    Ensembl:ENSMUSG00000074141 AllianceGenome:MGI:109552
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    H4; H-4; H46; LAO; Fig1; H-46; LAAO; mIL4I1; Fig1-ps
    Summary
    Enables L-amino-acid oxidase activity. Involved in negative regulation of T cell mediated immune response to tumor cell; positive regulation of regulatory T cell differentiation; and regulation of B cell differentiation. Acts upstream of or within aromatic amino acid family metabolic process. Located in lysosome. Orthologous to human IL4I1 (interleukin 4 induced 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in spleen adult (RPKM 71.1), testis adult (RPKM 39.3) and 7 other tissues See more
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    Genomic context

    See Il4i1 in Genome Data Viewer
    Location:
    7 B3; 7 28.93 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (44485712..44490233)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (44836288..44840809)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_18814 Neighboring gene predicted gene, 29791 Neighboring gene STARR-seq mESC enhancer starr_18815 Neighboring gene STARR-seq mESC enhancer starr_18816 Neighboring gene STARR-positive B cell enhancer ABC_E1086 Neighboring gene activating transcription factor 5 Neighboring gene interleukin 4 induced 1B Neighboring gene nucleoporin 62 Neighboring gene STARR-positive B cell enhancer ABC_E9111 Neighboring gene TBC1 domain family, member 17 Neighboring gene AKT1 substrate 1 Neighboring gene microRNA 707 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:52112565-52112765 Neighboring gene polynucleotide kinase 3'- phosphatase Neighboring gene prostate tumor over expressed gene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Readthrough Il4i1b

    Readthrough gene: Il4i1b, Included gene: Nup62

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables L-amino-acid oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables L-amino-acid oxidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables L-amino-acid oxidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables L-phenylalaine oxidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables polyamine oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in L-phenylalanine catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in L-phenylalanine catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in amino acid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within aromatic amino acid metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of T cell activation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of T cell activation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of T cell mediated immune response to tumor cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of T cell mediated immune response to tumor cell IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of T cell mediated immune response to tumor cell ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of T cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of regulatory T cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of regulatory T cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of positive regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of B cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of adaptive immune response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of adaptive immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in tryptophan catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in tryptophan catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in tryptophan catabolic process to indole-3-acetate ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in tryptophan catabolic process to indole-3-acetate ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in tyrosine catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in tyrosine catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in acrosomal vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in acrosomal vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular region ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in immunological synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in immunological synapse ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in lysosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in sperm midpiece ISO
    Inferred from Sequence Orthology
    more info
     
    located_in sperm midpiece ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    L-amino-acid oxidase
    Names
    IL4-induced protein 1
    histocompatibility 46
    interleukin-4-induced protein 1
    interleukin-four induced gene 1
    interleukin-four induced gene-1 protein
    interleukin-four induced protein-1
    protein Fig-1
    NP_034345.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010215.3NP_034345.2  L-amino-acid oxidase precursor

      See identical proteins and their annotated locations for NP_034345.2

      Status: VALIDATED

      Source sequence(s)
      AK150582, AK151731, U70429
      Consensus CDS
      CCDS21217.1
      UniProtKB/Swiss-Prot
      O09046, Q1LZI6, Q3T9N9, Q3U7S6, Q3V0K2, Q6Y632, Q6YBV6, Q6YDI8, Q8R2G8, Q9CXK7
      UniProtKB/TrEMBL
      A0A0R4J0C2
      Related
      ENSMUSP00000033015.8, ENSMUST00000033015.8
      Conserved Domains (1) summary
      pfam01593
      Location:75503
      Amino_oxidase; Flavin containing amine oxidoreductase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      44485712..44490233
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)