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    Fh1 fumarate hydratase 1 [ Mus musculus (house mouse) ]

    Gene ID: 14194, updated on 23-Jun-2021

    Summary

    Official Symbol
    Fh1provided by MGI
    Official Full Name
    fumarate hydratase 1provided by MGI
    Primary source
    MGI:MGI:95530
    See related
    Ensembl:ENSMUSG00000026526
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fh; Fh-1; fuma
    Expression
    Ubiquitous expression in heart adult (RPKM 118.0), placenta adult (RPKM 84.7) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Fh1 in Genome Data Viewer
    Location:
    1; 1 H3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (175428944..175453201, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (175601378..175625635, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (177531509..177555766, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene gremlin 2, DAN family BMP antagonist Neighboring gene regulator of G protein signaling 7 Neighboring gene predicted gene, 53483 Neighboring gene kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) Neighboring gene opsin 3 Neighboring gene choroideremia-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables fumarate hydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables fumarate hydratase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables fumarate hydratase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to DNA damage stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in fumarate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in fumarate metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in fumarate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within homeostasis of number of cells within a tissue IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in malate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in malate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of histone H3-K36 methylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cold-induced thermogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of double-strand break repair via nonhomologous end joining ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of arginine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in tricarboxylic acid cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in tricarboxylic acid cycle ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of urea cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in site of double-strand break ISO
    Inferred from Sequence Orthology
    more info
     
    part_of tricarboxylic acid cycle enzyme complex IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    fumarate hydratase, mitochondrial
    Names
    EF-3
    fumarase
    NP_034339.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010209.2NP_034339.2  fumarate hydratase, mitochondrial precursor

      See identical proteins and their annotated locations for NP_034339.2

      Status: VALIDATED

      Source sequence(s)
      AK147000, BQ174129, BU526396
      Consensus CDS
      CCDS15547.1
      UniProtKB/Swiss-Prot
      P97807
      Related
      ENSMUSP00000027810.8, ENSMUST00000027810.14
      Conserved Domains (1) summary
      PRK00485
      Location:46507
      fumC; fumarate hydratase; Reviewed

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      175428944..175453201 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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