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    Fgf1 fibroblast growth factor 1 [ Mus musculus (house mouse) ]

    Gene ID: 14164, updated on 10-Feb-2019

    Summary

    Official Symbol
    Fgf1provided by MGI
    Official Full Name
    fibroblast growth factor 1provided by MGI
    Primary source
    MGI:MGI:95515
    See related
    Ensembl:ENSMUSG00000036585
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fam; Fgfa; Dffrx; Fgf-1
    Expression
    Broad expression in lung adult (RPKM 20.2), heart adult (RPKM 15.2) and 16 other tissues See more
    Orthologs

    Genomic context

    See Fgf1 in Genome Data Viewer
    Location:
    18 B3; 18 20.74 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 18 NC_000084.6 (38838672..38929480, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (38998327..39078353, complement)

    Chromosome 18 - NC_000084.6Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein 26 Neighboring gene predicted gene, 46642 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene predicted gene, 38447 Neighboring gene predicted gene 5820 Neighboring gene predicted gene, 41705 Neighboring gene predicted gene, 30572

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    Hsp70 protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    S100 protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    fibroblast growth factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    growth factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    heparin binding ISO
    Inferred from Sequence Orthology
    more info
     
    integrin binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    activation of MAPK activity ISO
    Inferred from Sequence Orthology
    more info
     
    activation of protein kinase B activity ISO
    Inferred from Sequence Orthology
    more info
     
    angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    branch elongation involved in ureteric bud branching ISO
    Inferred from Sequence Orthology
    more info
     
    cardiac muscle cell proliferation TAS
    Traceable Author Statement
    more info
    PubMed 
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to heat ISO
    Inferred from Sequence Orthology
    more info
     
    fibroblast growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    lung development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mesonephric epithelium development ISO
    Inferred from Sequence Orthology
    more info
     
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    organ induction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of MAP kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell division ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cholesterol biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of epithelial cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription, DNA-templated TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of endothelial cell chemotaxis to fibroblast growth factor ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of endothelial tube morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    vasculogenesis involved in coronary vascular morphogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular region ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    fibroblast growth factor 1
    Names
    HBGF-1
    aFGF
    acidic fibroblast growth factor
    fibroblast growth factor 1 (acidic)
    heparin-binding growth factor 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010197.3NP_034327.1  fibroblast growth factor 1 precursor

      See identical proteins and their annotated locations for NP_034327.1

      Status: VALIDATED

      Source sequence(s)
      AC132098, AK035330
      Consensus CDS
      CCDS29204.1
      UniProtKB/Swiss-Prot
      P61148
      UniProtKB/TrEMBL
      Q6ZWS1
      Related
      ENSMUSP00000045710.4, ENSMUST00000040647.10
      Conserved Domains (1) summary
      pfam00167
      Location:25148
      FGF; Fibroblast growth factor

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000084.6 Reference GRCm38.p4 C57BL/6J

      Range
      38838672..38929480 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017317831.1XP_017173320.1  fibroblast growth factor 1 isoform X5

      Conserved Domains (1) summary
      pfam00167
      Location:25147
      FGF; Fibroblast growth factor
    2. XM_006525647.3XP_006525710.1  fibroblast growth factor 1 isoform X4

      See identical proteins and their annotated locations for XP_006525710.1

      UniProtKB/Swiss-Prot
      P61148
      UniProtKB/TrEMBL
      Q6ZWS1
      Conserved Domains (1) summary
      pfam00167
      Location:25148
      FGF; Fibroblast growth factor
    3. XM_006525644.3XP_006525707.1  fibroblast growth factor 1 isoform X4

      See identical proteins and their annotated locations for XP_006525707.1

      UniProtKB/Swiss-Prot
      P61148
      UniProtKB/TrEMBL
      Q6ZWS1
      Conserved Domains (1) summary
      pfam00167
      Location:25148
      FGF; Fibroblast growth factor
    4. XM_011246843.2XP_011245145.1  fibroblast growth factor 1 isoform X4

      See identical proteins and their annotated locations for XP_011245145.1

      UniProtKB/Swiss-Prot
      P61148
      UniProtKB/TrEMBL
      Q6ZWS1
      Conserved Domains (1) summary
      pfam00167
      Location:25148
      FGF; Fibroblast growth factor
    5. XM_017317830.1XP_017173319.1  fibroblast growth factor 1 isoform X4

      UniProtKB/Swiss-Prot
      P61148
      UniProtKB/TrEMBL
      Q6ZWS1
      Conserved Domains (1) summary
      pfam00167
      Location:25148
      FGF; Fibroblast growth factor
    6. XM_011246842.2XP_011245144.1  fibroblast growth factor 1 isoform X4

      See identical proteins and their annotated locations for XP_011245144.1

      UniProtKB/Swiss-Prot
      P61148
      UniProtKB/TrEMBL
      Q6ZWS1
      Conserved Domains (1) summary
      pfam00167
      Location:25148
      FGF; Fibroblast growth factor
    7. XM_006525648.3XP_006525711.1  fibroblast growth factor 1 isoform X4

      See identical proteins and their annotated locations for XP_006525711.1

      UniProtKB/Swiss-Prot
      P61148
      UniProtKB/TrEMBL
      Q6ZWS1
      Conserved Domains (1) summary
      pfam00167
      Location:25148
      FGF; Fibroblast growth factor
    8. XM_011246841.2XP_011245143.1  fibroblast growth factor 1 isoform X3

      Conserved Domains (1) summary
      pfam00167
      Location:42165
      FGF; Fibroblast growth factor
    9. XM_006525649.1XP_006525712.1  fibroblast growth factor 1 isoform X4

      See identical proteins and their annotated locations for XP_006525712.1

      UniProtKB/Swiss-Prot
      P61148
      UniProtKB/TrEMBL
      Q6ZWS1
      Conserved Domains (1) summary
      pfam00167
      Location:25148
      FGF; Fibroblast growth factor
    10. XM_006525642.3XP_006525705.1  fibroblast growth factor 1 isoform X2

      Conserved Domains (1) summary
      pfam00167
      Location:47169
      FGF; Fibroblast growth factor
    11. XM_006525641.3XP_006525704.1  fibroblast growth factor 1 isoform X1

      Conserved Domains (1) summary
      pfam00167
      Location:47170
      FGF; Fibroblast growth factor
    12. XM_006525645.3XP_006525708.1  fibroblast growth factor 1 isoform X4

      See identical proteins and their annotated locations for XP_006525708.1

      UniProtKB/Swiss-Prot
      P61148
      UniProtKB/TrEMBL
      Q6ZWS1
      Related
      ENSMUSP00000111245.1, ENSMUST00000115582.7
      Conserved Domains (1) summary
      pfam00167
      Location:25148
      FGF; Fibroblast growth factor
    13. XM_017317832.1XP_017173321.1  fibroblast growth factor 1 isoform X6

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