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    Fgf1 fibroblast growth factor 1 [ Mus musculus (house mouse) ]

    Gene ID: 14164, updated on 8-Jul-2021

    Summary

    Official Symbol
    Fgf1provided by MGI
    Official Full Name
    fibroblast growth factor 1provided by MGI
    Primary source
    MGI:MGI:95515
    See related
    Ensembl:ENSMUSG00000036585
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fam; Fgf; Fgfa; Dffrx; Fgf-1; Fgf2b
    Expression
    Broad expression in lung adult (RPKM 20.2), heart adult (RPKM 15.2) and 16 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Fgf1 in Genome Data Viewer
    Location:
    18 B3; 18 20.74 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (38971725..39062532, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (38838672..38929470, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (38998327..39078353, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein 26 Neighboring gene predicted gene, 19774 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene predicted gene 5820 Neighboring gene predicted gene, 52330 Neighboring gene predicted gene 15337

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables Hsp70 protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables S100 protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables fibroblast growth factor receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables fibroblast growth factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables growth factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables growth factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables heparin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables integrin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in activation of protein kinase B activity ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in animal organ morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in branch elongation involved in ureteric bud branching ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cardiac muscle cell proliferation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cellular response to heat ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in fibroblast growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lung development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within lung development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in mesonephric epithelium development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within organ induction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of MAP kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of MAP kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell division ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cholesterol biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of endothelial cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of epithelial cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of epithelial cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of hepatocyte proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription, DNA-templated TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of endothelial cell chemotaxis to fibroblast growth factor ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of endothelial tube morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in vasculogenesis involved in coronary vascular morphogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in wound healing IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in wound healing ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    fibroblast growth factor 1
    Names
    HBGF-1
    aFGF
    acidic fibroblast growth factor
    fibroblast growth factor 1 (acidic)
    fibroblast growth factor 2b
    heparin-binding growth factor 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010197.3NP_034327.1  fibroblast growth factor 1

      See identical proteins and their annotated locations for NP_034327.1

      Status: VALIDATED

      Source sequence(s)
      AC132098, AK035330
      Consensus CDS
      CCDS29204.1
      UniProtKB/Swiss-Prot
      P61148
      UniProtKB/TrEMBL
      Q6ZWS1
      Related
      ENSMUSP00000045710.5, ENSMUST00000040647.11
      Conserved Domains (1) summary
      pfam00167
      Location:25148
      FGF; Fibroblast growth factor

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      38971725..39062532 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006525647.4XP_006525710.1  fibroblast growth factor 1 isoform X4

      See identical proteins and their annotated locations for XP_006525710.1

      UniProtKB/Swiss-Prot
      P61148
      UniProtKB/TrEMBL
      Q6ZWS1
      Conserved Domains (1) summary
      pfam00167
      Location:25148
      FGF; Fibroblast growth factor
    2. XM_017317831.2XP_017173320.1  fibroblast growth factor 1 isoform X5

      Conserved Domains (1) summary
      pfam00167
      Location:25147
      FGF; Fibroblast growth factor
    3. XM_006525644.4XP_006525707.1  fibroblast growth factor 1 isoform X4

      See identical proteins and their annotated locations for XP_006525707.1

      UniProtKB/Swiss-Prot
      P61148
      UniProtKB/TrEMBL
      Q6ZWS1
      Conserved Domains (1) summary
      pfam00167
      Location:25148
      FGF; Fibroblast growth factor
    4. XM_036160985.1XP_036016878.1  fibroblast growth factor 1 isoform X4

      Conserved Domains (1) summary
      pfam00167
      Location:25148
      FGF; Fibroblast growth factor
    5. XM_011246843.3XP_011245145.1  fibroblast growth factor 1 isoform X4

      See identical proteins and their annotated locations for XP_011245145.1

      UniProtKB/Swiss-Prot
      P61148
      UniProtKB/TrEMBL
      Q6ZWS1
      Conserved Domains (1) summary
      pfam00167
      Location:25148
      FGF; Fibroblast growth factor
    6. XM_017317830.1XP_017173319.1  fibroblast growth factor 1 isoform X4

      UniProtKB/Swiss-Prot
      P61148
      UniProtKB/TrEMBL
      Q6ZWS1
      Conserved Domains (1) summary
      pfam00167
      Location:25148
      FGF; Fibroblast growth factor
    7. XM_011246842.3XP_011245144.1  fibroblast growth factor 1 isoform X4

      See identical proteins and their annotated locations for XP_011245144.1

      UniProtKB/Swiss-Prot
      P61148
      UniProtKB/TrEMBL
      Q6ZWS1
      Conserved Domains (1) summary
      pfam00167
      Location:25148
      FGF; Fibroblast growth factor
    8. XM_036160986.1XP_036016879.1  fibroblast growth factor 1 isoform X4

      Conserved Domains (1) summary
      pfam00167
      Location:25148
      FGF; Fibroblast growth factor
    9. XM_036160987.1XP_036016880.1  fibroblast growth factor 1 isoform X4

      Conserved Domains (1) summary
      pfam00167
      Location:25148
      FGF; Fibroblast growth factor
    10. XM_006525648.5XP_006525711.1  fibroblast growth factor 1 isoform X4

      See identical proteins and their annotated locations for XP_006525711.1

      UniProtKB/Swiss-Prot
      P61148
      UniProtKB/TrEMBL
      Q6ZWS1
      Conserved Domains (1) summary
      pfam00167
      Location:25148
      FGF; Fibroblast growth factor
    11. XM_011246841.4XP_011245143.1  fibroblast growth factor 1 isoform X3

      Conserved Domains (1) summary
      pfam00167
      Location:42165
      FGF; Fibroblast growth factor
    12. XM_006525649.3XP_006525712.1  fibroblast growth factor 1 isoform X4

      See identical proteins and their annotated locations for XP_006525712.1

      UniProtKB/Swiss-Prot
      P61148
      UniProtKB/TrEMBL
      Q6ZWS1
      Related
      ENSMUSP00000157968.2, ENSMUST00000236630.2
      Conserved Domains (1) summary
      pfam00167
      Location:25148
      FGF; Fibroblast growth factor
    13. XM_006525642.5XP_006525705.1  fibroblast growth factor 1 isoform X2

      Conserved Domains (1) summary
      pfam00167
      Location:47169
      FGF; Fibroblast growth factor
    14. XM_006525641.5XP_006525704.1  fibroblast growth factor 1 isoform X1

      Conserved Domains (1) summary
      pfam00167
      Location:47170
      FGF; Fibroblast growth factor
    15. XM_006525645.5XP_006525708.1  fibroblast growth factor 1 isoform X4

      See identical proteins and their annotated locations for XP_006525708.1

      UniProtKB/Swiss-Prot
      P61148
      UniProtKB/TrEMBL
      Q6ZWS1
      Related
      ENSMUSP00000111245.2, ENSMUST00000115582.8
      Conserved Domains (1) summary
      pfam00167
      Location:25148
      FGF; Fibroblast growth factor
    16. XM_036160988.1XP_036016881.1  fibroblast growth factor 1 isoform X7

      Related
      ENSMUSP00000123293.2, ENSMUST00000131348.8
      Conserved Domains (1) summary
      cl00060
      Location:2556
      FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...
    17. XM_017317832.3XP_017173321.1  fibroblast growth factor 1 isoform X6

      Conserved Domains (1) summary
      cl00060
      Location:4778
      FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...
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