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    Fer fer (fms/fps related) protein kinase [ Mus musculus (house mouse) ]

    Gene ID: 14158, updated on 23-Jun-2021

    Summary

    Official Symbol
    Ferprovided by MGI
    Official Full Name
    fer (fms/fps related) protein kinaseprovided by MGI
    Primary source
    MGI:MGI:105917
    See related
    Ensembl:ENSMUSG00000000127
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fer; Fert; Fert2; AV082135; C330004K01Rik
    Expression
    Ubiquitous expression in CNS E18 (RPKM 3.4), whole brain E14.5 (RPKM 3.1) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Fer in Genome Data Viewer
    Location:
    17; 17 E1.1
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (64136945..64453515)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (63862073..64146519)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (64245367..64488845)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene RAN, member RAS oncogene family pseudogene Neighboring gene predicted gene, 53982 Neighboring gene predicted gene, 52300 Neighboring gene RIKEN cDNA 1110058D11 gene Neighboring gene predicted gene, 46590 Neighboring gene ribosomal protein L36, pseudogene 6 Neighboring gene predicted gene, 34858

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables actin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables cadherin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables cell adhesion molecule binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables cytoskeletal protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables epidermal growth factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables gamma-catenin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables lipid binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables non-membrane spanning protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables non-membrane spanning protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein phosphatase 1 binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in Fc-epsilon receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in Fc-epsilon receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in Kit signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in actin cytoskeleton reorganization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell-cell adhesion mediated by cadherin IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to insulin stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to macrophage colony-stimulating factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to reactive oxygen species IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cytokine-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in diapedesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in extracellular matrix-cell signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in insulin receptor signaling pathway via phosphatidylinositol 3-kinase IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in interleukin-6-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in microtubule cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of mast cell activation involved in immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in platelet-derived growth factor receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of actin filament polymerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of epidermal growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of fibroblast migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of lamellipodium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of mast cell degranulation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to lipopolysaccharide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to platelet-derived growth factor IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in substrate adhesion-dependent cell spreading IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in transmembrane receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in tyrosine phosphorylation of STAT protein ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    colocalizes_with actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in extrinsic component of cytoplasmic side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in extrinsic component of cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with lamellipodium ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    tyrosine-protein kinase Fer
    Names
    fer (fms/fps related) protein kinase, testis specific 2
    p94-Fer
    proto-oncogene c-Fer
    proto-oncogene tyrosine-protein kinase Fer
    NP_001033086.2
    NP_001273344.1
    NP_032026.2
    XP_006523703.1
    XP_006523704.1
    XP_006523706.1
    XP_006523708.1
    XP_006523713.1
    XP_011244595.1
    XP_017172732.1
    XP_017172733.1
    XP_030105356.1
    XP_036016207.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037997.3NP_001033086.2  tyrosine-protein kinase Fer isoform a

      See identical proteins and their annotated locations for NP_001033086.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AK157828, AK165973, BC058100
      Consensus CDS
      CCDS28936.1
      UniProtKB/Swiss-Prot
      P70451
      UniProtKB/TrEMBL
      Q3TME9, Q3TZJ5
      Related
      ENSMUSP00000000129.7, ENSMUST00000000129.14
      Conserved Domains (3) summary
      cd07686
      Location:5238
      F-BAR_Fer; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Fer (Fes related) tyrosine kinase
      cd10361
      Location:454539
      SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
      cl21453
      Location:567817
      PKc_like; Protein Kinases, catalytic domain
    2. NM_001286415.1NP_001273344.1  tyrosine-protein kinase Fer isoform c

      See identical proteins and their annotated locations for NP_001273344.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR exon, and lacks an in-frame exon in the 5' coding region, compared to variant 1. The encoded isoform (c) lacks an internal segment, compared to isoform a.
      Source sequence(s)
      BC058100
      Consensus CDS
      CCDS89132.1
      UniProtKB/Swiss-Prot
      P70451
      Related
      ENSMUSP00000156523.2, ENSMUST00000233190.2
      Conserved Domains (4) summary
      cd10361
      Location:396481
      SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
      pfam07714
      Location:506757
      Pkinase_Tyr; Protein tyrosine kinase
      cl12013
      Location:5180
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
      cl21453
      Location:509759
      PKc_like; Protein Kinases, catalytic domain
    3. NM_008000.2NP_032026.2  tyrosine-protein kinase Fer isoform b

      See identical proteins and their annotated locations for NP_032026.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, and has multiple differences in the coding region, compared to variant 1. The encoded isoform (b) has a distinct and shorter N-terminus and lacks an internal aa, compared to isoform a.
      Source sequence(s)
      BC058100, M32054
      Consensus CDS
      CCDS28937.1
      UniProtKB/Swiss-Prot
      P70451
      Related
      ENSMUSP00000037418.6, ENSMUST00000038080.7
      Conserved Domains (3) summary
      cd10361
      Location:84169
      SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
      pfam07714
      Location:194445
      Pkinase_Tyr; Protein tyrosine kinase
      cl21453
      Location:197447
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      64136945..64453515
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160314.1XP_036016207.1  tyrosine-protein kinase Fer isoform X1

      Conserved Domains (3) summary
      cd07686
      Location:5238
      F-BAR_Fer; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Fer (Fes related) tyrosine kinase
      cd10361
      Location:454539
      SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
      cl21453
      Location:567817
      PKc_like; Protein Kinases, catalytic domain
    2. XM_006523641.5XP_006523704.1  tyrosine-protein kinase Fer isoform X1

      See identical proteins and their annotated locations for XP_006523704.1

      UniProtKB/Swiss-Prot
      P70451
      Conserved Domains (3) summary
      cd07686
      Location:5238
      F-BAR_Fer; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Fer (Fes related) tyrosine kinase
      cd10361
      Location:454539
      SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
      cl21453
      Location:567817
      PKc_like; Protein Kinases, catalytic domain
    3. XM_030249496.2XP_030105356.1  tyrosine-protein kinase Fer isoform X2

      Conserved Domains (3) summary
      cd07686
      Location:5238
      F-BAR_Fer; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Fer (Fes related) tyrosine kinase
      cd10361
      Location:453538
      SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
      cl21453
      Location:566816
      PKc_like; Protein Kinases, catalytic domain
    4. XM_006523643.5XP_006523706.1  tyrosine-protein kinase Fer isoform X2

      See identical proteins and their annotated locations for XP_006523706.1

      UniProtKB/Swiss-Prot
      P70451
      Conserved Domains (3) summary
      cd07686
      Location:5238
      F-BAR_Fer; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Fer (Fes related) tyrosine kinase
      cd10361
      Location:453538
      SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
      cl21453
      Location:566816
      PKc_like; Protein Kinases, catalytic domain
    5. XM_006523645.5XP_006523708.1  tyrosine-protein kinase Fer isoform X3

      Conserved Domains (3) summary
      cd10361
      Location:381466
      SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
      cl12013
      Location:1165
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
      cl21453
      Location:494744
      PKc_like; Protein Kinases, catalytic domain
    6. XM_006523650.5XP_006523713.1  tyrosine-protein kinase Fer isoform X6

      Conserved Domains (1) summary
      cl12013
      Location:5238
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    7. XM_006523640.5XP_006523703.1  tyrosine-protein kinase Fer isoform X1

      See identical proteins and their annotated locations for XP_006523703.1

      UniProtKB/Swiss-Prot
      P70451
      Conserved Domains (3) summary
      cd07686
      Location:5238
      F-BAR_Fer; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Fer (Fes related) tyrosine kinase
      cd10361
      Location:454539
      SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
      cl21453
      Location:567817
      PKc_like; Protein Kinases, catalytic domain
    8. XM_011246293.4XP_011244595.1  tyrosine-protein kinase Fer isoform X2

      See identical proteins and their annotated locations for XP_011244595.1

      UniProtKB/Swiss-Prot
      P70451
      Conserved Domains (3) summary
      cd07686
      Location:5238
      F-BAR_Fer; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Fer (Fes related) tyrosine kinase
      cd10361
      Location:453538
      SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
      cl21453
      Location:566816
      PKc_like; Protein Kinases, catalytic domain
    9. XM_017317243.2XP_017172732.1  tyrosine-protein kinase Fer isoform X4

      Conserved Domains (2) summary
      cd10361
      Location:85170
      SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
      cl21453
      Location:198448
      PKc_like; Protein Kinases, catalytic domain
    10. XM_017317244.2XP_017172733.1  tyrosine-protein kinase Fer isoform X5

      Conserved Domains (2) summary
      cd10361
      Location:65150
      SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
      cl21453
      Location:178428
      PKc_like; Protein Kinases, catalytic domain

    RNA

    1. XR_003952084.2 RNA Sequence

    2. XR_003952086.2 RNA Sequence

    3. XR_385280.5 RNA Sequence

    4. XR_003952085.2 RNA Sequence

    5. XR_003952087.2 RNA Sequence

    6. XR_385281.5 RNA Sequence

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