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    Fdft1 farnesyl diphosphate farnesyl transferase 1 [ Mus musculus (house mouse) ]

    Gene ID: 14137, updated on 23-Jun-2021

    Summary

    Official Symbol
    Fdft1provided by MGI
    Official Full Name
    farnesyl diphosphate farnesyl transferase 1provided by MGI
    Primary source
    MGI:MGI:102706
    See related
    Ensembl:ENSMUSG00000021273
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    S; SS; SQS
    Expression
    Ubiquitous expression in testis adult (RPKM 35.8), CNS E18 (RPKM 14.9) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Fdft1 in Genome Data Viewer
    Location:
    14 D1; 14 33.24 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (63382599..63419136, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (63145150..63181687, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (63763987..63796630, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 36025 Neighboring gene tubulin, alpha 3B pseudogene Neighboring gene predicted gene, 23629 Neighboring gene cathepsin B Neighboring gene microRNA 12185 Neighboring gene predicted gene, 53861 Neighboring gene nei like 2 (E. coli) Neighboring gene GATA binding protein 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables farnesyl-diphosphate farnesyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables farnesyl-diphosphate farnesyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables squalene synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity, transferring alkyl or aryl (other than methyl) groups IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cholesterol biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cholesterol biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cholesterol metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in farnesyl diphosphate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in farnesyl diphosphate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within isoprenoid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within steroid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within steroid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within sterol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    squalene synthase
    Names
    FPP:FPP farnesyltransferase
    farnesyl-diphosphate farnesyltransferase
    NP_001347140.1
    NP_034321.2
    XP_006518610.1
    XP_017171333.1
    XP_036014350.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360211.1NP_001347140.1  squalene synthase

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents transcription from a major CAGE transcription cluster, and represents the shorter transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK169317, BC054722, BY293142
      Consensus CDS
      CCDS27198.1
      Related
      ENSMUSP00000055313.10, ENSMUST00000054963.10
      Conserved Domains (1) summary
      cl00210
      Location:38370
      Isoprenoid_Biosyn_C1; Isoprenoid Biosynthesis enzymes, Class 1
    2. NM_010191.3NP_034321.2  squalene synthase

      See identical proteins and their annotated locations for NP_034321.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK136159, BC054722
      Consensus CDS
      CCDS27198.1
      UniProtKB/Swiss-Prot
      P53798
      Related
      ENSMUSP00000153671.2, ENSMUST00000224625.2
      Conserved Domains (1) summary
      cl00210
      Location:38370
      Isoprenoid_Biosyn_C1; Isoprenoid Biosynthesis enzymes, Class 1

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      63382599..63419136 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017315844.1XP_017171333.1  squalene synthase isoform X1

      UniProtKB/Swiss-Prot
      P53798
      Conserved Domains (1) summary
      cl00210
      Location:38370
      Isoprenoid_Biosyn_C1; Isoprenoid Biosynthesis enzymes, Class 1
    2. XM_036158457.1XP_036014350.1  squalene synthase isoform X2

      Conserved Domains (1) summary
      cl00210
      Location:18276
      Isoprenoid_Biosyn_C1; Isoprenoid Biosynthesis enzymes, Class 1
    3. XM_006518547.5XP_006518610.1  squalene synthase isoform X3

      Conserved Domains (1) summary
      cl00210
      Location:1221
      Isoprenoid_Biosyn_C1; Isoprenoid Biosynthesis enzymes, Class 1
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