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    Fbl fibrillarin [ Mus musculus (house mouse) ]

    Gene ID: 14113, updated on 27-Nov-2024

    Summary

    Official Symbol
    Fblprovided by MGI
    Official Full Name
    fibrillarinprovided by MGI
    Primary source
    MGI:MGI:95486
    See related
    Ensembl:ENSMUSG00000046865 AllianceGenome:MGI:95486
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    FIB; FLRN; RNU3IP1
    Summary
    Enables RNA binding activity. Acts upstream of or within sno(s)RNA metabolic process. Located in Cajal body and granular component. Is expressed in several structures, including central nervous system; early embryo; oocyte; retina; and submandibular gland primordium. Orthologous to human FBL (fibrillarin). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 132.0), liver E14 (RPKM 128.6) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Fbl in Genome Data Viewer
    Location:
    7 A3; 7 16.67 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (27868293..27878701)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (28168893..28179269)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene tectorin alpha pseudogene Neighboring gene predicted gene, 38976 Neighboring gene Fc fragment of IgG binding protein like 1 Neighboring gene STARR-seq mESC enhancer starr_18401 Neighboring gene STARR-seq mESC enhancer starr_18402 Neighboring gene STARR-positive B cell enhancer ABC_E6526 Neighboring gene predicted gene, 31024 Neighboring gene STARR-positive B cell enhancer ABC_E9687 Neighboring gene dual-specificity tyrosine phosphorylation regulated kinase 1b Neighboring gene STARR-seq mESC enhancer starr_18404 Neighboring gene STARR-seq mESC enhancer starr_18406 Neighboring gene STARR-seq mESC enhancer starr_18407 Neighboring gene STARR-seq mESC enhancer starr_18408 Neighboring gene ring finger and WD repeat domain 2 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATPase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables TFIID-class transcription factor complex binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables TFIID-class transcription factor complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables U6 snRNA 2'-O-ribose methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AQ104 methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables histone H2AQ104 methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone H2AQ104 methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables rRNA methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in box C/D sno(s)RNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in rRNA methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in rRNA methylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in rRNA methylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in ribosomal small subunit biogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ribosomal small subunit biogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within sno(s)RNA metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in snoRNA localization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in snoRNA localization ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in Cajal body IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in Cajal body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in Cajal body ISO
    Inferred from Sequence Orthology
    more info
     
    part_of box C/D methylation guide snoRNP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in chromosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dense fibrillar component ISO
    Inferred from Sequence Orthology
    more info
     
    located_in fibrillar center IEA
    Inferred from Electronic Annotation
    more info
     
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
     
    located_in granular component IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in nucleolus ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of small-subunit processome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of small-subunit processome ISO
    Inferred from Sequence Orthology
    more info
     
    part_of small-subunit processome ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    rRNA 2'-O-methyltransferase fibrillarin
    Names
    U6 snRNA 2'-O-methyltransferase fibrillarin
    histone-glutamine methyltransferase
    nucleolar protein 1
    NP_001399349.1
    NP_032017.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001412420.1NP_001399349.1  rRNA 2'-O-methyltransferase fibrillarin isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC141883
    2. NM_007991.4NP_032017.2  rRNA 2'-O-methyltransferase fibrillarin isoform 1

      See identical proteins and their annotated locations for NP_032017.2

      Status: VALIDATED

      Source sequence(s)
      AC141883
      Consensus CDS
      CCDS21036.1
      UniProtKB/Swiss-Prot
      P35550, Q99L58
      UniProtKB/TrEMBL
      Q3UJS2
      Related
      ENSMUSP00000037613.7, ENSMUST00000042405.8
      Conserved Domains (1) summary
      PTZ00146
      Location:88326
      PTZ00146; fibrillarin; Provisional

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      27868293..27878701
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)