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    Fat1 FAT atypical cadherin 1 [ Mus musculus (house mouse) ]

    Gene ID: 14107, updated on 11-Nov-2018

    Summary

    Official Symbol
    Fat1provided by MGI
    Official Full Name
    FAT atypical cadherin 1provided by MGI
    Primary source
    MGI:MGI:109168
    See related
    Ensembl:ENSMUSG00000070047 Vega:OTTMUSG00000048086
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fath; mFat1; AU023433; 2310038E12Rik
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 20.3), colon adult (RPKM 15.5) and 24 other tissues See more
    Orthologs

    Genomic context

    See Fat1 in Genome Data Viewer
    Location:
    8 B1.1; 8 24.81 cM
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 8 NC_000074.6 (44935046..45052257)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (46035562..46137611)

    Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene dynein light chain 1, cytoplasmic-like Neighboring gene predicted gene, 30397 Neighboring gene cDNA sequence AY512931 Neighboring gene melatonin receptor 1A

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    actin filament organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    camera-type eye morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell-cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    epithelial cell morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    establishment or maintenance of cell polarity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    establishment or maintenance of epithelial cell apical/basal polarity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    filopodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lamellipodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    protocadherin Fat 1
    Names
    FAT tumor suppressor homolog 1
    fat 1 cadherin

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081286.2NP_001074755.2  protocadherin Fat 1 precursor

      See identical proteins and their annotated locations for NP_001074755.2

      Status: VALIDATED

      Source sequence(s)
      AC119214, AC158352
      Consensus CDS
      CCDS52547.1
      UniProtKB/TrEMBL
      F2Z4A3
      Related
      ENSMUSP00000096394.3, ENSMUST00000098796.9
      Conserved Domains (5) summary
      cd11304
      Location:32363333
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00282
      Location:38563987
      LamG; Laminin G domain
      cd00054
      Location:41294165
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam00008
      Location:40954125
      EGF; EGF-like domain
      cl09101
      Location:278357
      E_set; Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000074.6 Reference GRCm38.p4 C57BL/6J

      Range
      44935046..45052257
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006509276.3XP_006509339.1  protocadherin Fat 1 isoform X8

      See identical proteins and their annotated locations for XP_006509339.1

      Conserved Domains (5) summary
      cd11304
      Location:32593356
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00282
      Location:38794010
      LamG; Laminin G domain
      cd00054
      Location:41524188
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam00008
      Location:41184148
      EGF; EGF-like domain
      cl09101
      Location:278357
      E_set; Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus
    2. XM_006509267.3XP_006509330.1  protocadherin Fat 1 isoform X1

      See identical proteins and their annotated locations for XP_006509330.1

      UniProtKB/TrEMBL
      A0A1L1SQU7
      Conserved Domains (5) summary
      cd11304
      Location:32593356
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00282
      Location:38794010
      LamG; Laminin G domain
      cd00054
      Location:41524188
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam00008
      Location:41184148
      EGF; EGF-like domain
      cl09101
      Location:278357
      E_set; Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus
    3. XM_006509273.3XP_006509336.1  protocadherin Fat 1 isoform X5

      Conserved Domains (4) summary
      cd11304
      Location:32593356
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00282
      Location:38794010
      LamG; Laminin G domain
      cd00054
      Location:41154151
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cl09101
      Location:278357
      E_set; Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus
    4. XM_017312564.1XP_017168053.1  protocadherin Fat 1 isoform X7

    5. XM_006509270.3XP_006509333.1  protocadherin Fat 1 isoform X2

      Conserved Domains (5) summary
      cd11304
      Location:32593356
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00282
      Location:38794010
      LamG; Laminin G domain
      cd00054
      Location:41524188
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam00008
      Location:41184148
      EGF; EGF-like domain
      cl09101
      Location:278357
      E_set; Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus
    6. XM_006509272.3XP_006509335.1  protocadherin Fat 1 isoform X4

      Conserved Domains (5) summary
      cd11304
      Location:32593356
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00282
      Location:38794010
      LamG; Laminin G domain
      cd00054
      Location:41524188
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam00008
      Location:41184148
      EGF; EGF-like domain
      cl09101
      Location:278357
      E_set; Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus
    7. XM_006509271.3XP_006509334.1  protocadherin Fat 1 isoform X3

      Conserved Domains (5) summary
      cd11304
      Location:32363333
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00282
      Location:38563987
      LamG; Laminin G domain
      cd00054
      Location:41294165
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam00008
      Location:40954125
      EGF; EGF-like domain
      cl09101
      Location:278357
      E_set; Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus
    8. XM_006509277.3XP_006509340.1  protocadherin Fat 1 isoform X9

      UniProtKB/TrEMBL
      A0A087WRT4
      Related
      ENSMUSP00000140765.2, OTTMUSP00000077461, ENSMUST00000189017.7, OTTMUST00000123547
      Conserved Domains (5) summary
      cd11304
      Location:32363333
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00282
      Location:38563987
      LamG; Laminin G domain
      cd00054
      Location:41294165
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam00008
      Location:40954125
      EGF; EGF-like domain
      cl09101
      Location:278357
      E_set; Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus
    9. XM_006509274.3XP_006509337.1  protocadherin Fat 1 isoform X6

      See identical proteins and their annotated locations for XP_006509337.1

      UniProtKB/TrEMBL
      F2Z4A3
      Related
      ENSMUSP00000140596.1, OTTMUSP00000067437, ENSMUST00000191428.6, OTTMUST00000123546
      Conserved Domains (5) summary
      cd11304
      Location:32363333
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00282
      Location:38563987
      LamG; Laminin G domain
      cd00054
      Location:41294165
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam00008
      Location:40954125
      EGF; EGF-like domain
      cl09101
      Location:278357
      E_set; Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus
    10. XM_011242173.2XP_011240475.1  protocadherin Fat 1 isoform X1

      See identical proteins and their annotated locations for XP_011240475.1

      UniProtKB/TrEMBL
      A0A1L1SQU7
      Conserved Domains (5) summary
      cd11304
      Location:32593356
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00282
      Location:38794010
      LamG; Laminin G domain
      cd00054
      Location:41524188
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam00008
      Location:41184148
      EGF; EGF-like domain
      cl09101
      Location:278357
      E_set; Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus
    11. XM_006509268.3XP_006509331.1  protocadherin Fat 1 isoform X1

      See identical proteins and their annotated locations for XP_006509331.1

      UniProtKB/TrEMBL
      A0A1L1SQU7
      Related
      ENSMUSP00000149194.1, OTTMUSP00000079170, ENSMUST00000215588.1, OTTMUST00000152769
      Conserved Domains (5) summary
      cd11304
      Location:32593356
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00282
      Location:38794010
      LamG; Laminin G domain
      cd00054
      Location:41524188
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam00008
      Location:41184148
      EGF; EGF-like domain
      cl09101
      Location:278357
      E_set; Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus

    RNA

    1. XR_001778405.1 RNA Sequence

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