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    Faf1 Fas-associated factor 1 [ Mus musculus (house mouse) ]

    Gene ID: 14084, updated on 31-Jan-2019

    Summary

    Official Symbol
    Faf1provided by MGI
    Official Full Name
    Fas-associated factor 1provided by MGI
    Primary source
    MGI:MGI:109419
    See related
    Ensembl:ENSMUSG00000010517
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fam; Dffrx; AA408698
    Expression
    Ubiquitous expression in placenta adult (RPKM 10.0), CNS E18 (RPKM 8.3) and 28 other tissues See more
    Orthologs

    Genomic context

    See Faf1 in Genome Data Viewer
    Location:
    4 C7; 4 51.33 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 4 NC_000070.6 (109676627..109963960)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (109349232..109636565)

    Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 9630013D21 gene Neighboring gene cyclin dependent kinase inhibitor 2C Neighboring gene doublesex and mab-3 related transcription factor like family A2, opposite strand Neighboring gene doublesex and mab-3 related transcription factor like family A2 Neighboring gene predicted gene, 33070

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (3)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    NF-kappaB binding ISO
    Inferred from Sequence Orthology
    more info
     
    heat shock protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin binding ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    cell death ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasmic sequestering of NF-kappaB ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of DNA replication ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell death ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cellular protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of extrinsic apoptotic signaling pathway via death domain receptors IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of protein complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    VCP-NPL4-UFD1 AAA ATPase complex ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear envelope IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007983.2NP_032009.2  FAS-associated factor 1

      See identical proteins and their annotated locations for NP_032009.2

      Status: PROVISIONAL

      Source sequence(s)
      BC065098
      Consensus CDS
      CCDS18468.1
      UniProtKB/Swiss-Prot
      P54731
      Related
      ENSMUSP00000099785.4, ENSMUST00000102724.4
      Conserved Domains (4) summary
      cd01771
      Location:569648
      Faf1_UBX; Faf1 UBX domain
      cd02990
      Location:351486
      UAS_FAF1; UAS family, FAS-associated factor 1 (FAF1) subfamily; FAF1 contains a UAS domain of unknown function N-terminal to a ubiquitin-associated UBX domain. FAF1 also contains ubiquitin-associated UBA and nuclear targeting domains, N-terminal to the UAS domain. ...
      cd14413
      Location:1446
      UBA_FAF1; UBA-like domain found in FAS-associated factor 1 (FAF1) and similar proteins
      pfam00836
      Location:470558
      Stathmin; Stathmin family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000070.6 Reference GRCm38.p4 C57BL/6J

      Range
      109676627..109963960
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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