U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Ptk2 PTK2 protein tyrosine kinase 2 [ Mus musculus (house mouse) ]

    Gene ID: 14083, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ptk2provided by MGI
    Official Full Name
    PTK2 protein tyrosine kinase 2provided by MGI
    Primary source
    MGI:MGI:95481
    See related
    Ensembl:ENSMUSG00000022607 AllianceGenome:MGI:95481
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    FAK; FRNK; Fadk; FADK 1; p125FAK
    Summary
    Enables non-membrane spanning protein tyrosine kinase activity. Involved in several processes, including positive regulation of ubiquitin-dependent protein catabolic process; protein phosphorylation; and regulation of modification of postsynaptic actin cytoskeleton. Acts upstream of or within several processes, including blood vessel morphogenesis; generation of neurons; and negative regulation of nervous system development. Located in several cellular components, including apical plasma membrane; focal adhesion; and lamellipodium. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and vault of skull. Human ortholog(s) of this gene implicated in leiomyoma; lung small cell carcinoma; and pulmonary hypertension. Orthologous to human PTK2 (protein tyrosine kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in cortex adult (RPKM 12.3), CNS E11.5 (RPKM 11.8) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Ptk2 in Genome Data Viewer
    Location:
    15 D3; 15 33.94 cM
    Exon count:
    42
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (73076951..73297192, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (73205102..73423820, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_38946 Neighboring gene chromatin accessibility complex 1 Neighboring gene predicted gene, 31725 Neighboring gene STARR-positive B cell enhancer ABC_E8595 Neighboring gene argonaute RISC catalytic subunit 2 Neighboring gene STARR-positive B cell enhancer ABC_E7379 Neighboring gene STARR-positive B cell enhancer ABC_E10861 Neighboring gene STARR-positive B cell enhancer ABC_E7380 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:73017364-73017547 Neighboring gene STARR-seq mESC enhancer starr_38954 Neighboring gene STARR-seq mESC enhancer starr_38957 Neighboring gene microRNA 151 Neighboring gene predicted gene, 41344 Neighboring gene predicted gene, 24787 Neighboring gene STARR-seq mESC enhancer starr_38959 Neighboring gene STARR-positive B cell enhancer mm9_chr15:73254258-73254558 Neighboring gene protein tyrosine phosphatase-like (proline instead of catalytic arginine), member b pseudogene Neighboring gene STARR-seq mESC enhancer starr_38960 Neighboring gene ribosomal protein L17 pseudogene Neighboring gene STARR-seq mESC enhancer starr_38961 Neighboring gene STARR-positive B cell enhancer ABC_E7381 Neighboring gene cytochrome b-c1 complex subunit 6, mitochondrial pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Targeted (17)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA4203

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables JUN kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables SH2 domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables actin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone H2AXY142 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3Y41 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables integrin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables molecular function activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables non-membrane spanning protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables non-membrane spanning protein tyrosine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables non-membrane spanning protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables non-membrane spanning protein tyrosine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylinositol 3-kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein tyrosine kinase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    enables protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein tyrosine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein tyrosine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein tyrosine kinase activity TAS
    Traceable Author Statement
    more info
     
    enables protein tyrosine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in JNK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of axonogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within blood vessel development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cell migration TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to transforming growth factor beta stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within central nervous system neuron axonogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within endothelial cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in ephrin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ephrin receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in epidermal growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within extracellular matrix organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in growth hormone receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in integrin-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in integrin-mediated signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within integrin-mediated signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in intracellular chloride ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within microtubule cytoskeleton organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of anoikis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within negative regulation of autophagy IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of autophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of axonogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of organ growth IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of synapse assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within neuron migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within neuron migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within nuclear migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of organ growth IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within peptidyl-tyrosine autophosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in peptidyl-tyrosine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptidyl-tyrosine phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within positive regulation of cardiac muscle hypertrophy IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of epithelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of epithelial to mesenchymal transition ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of fibroblast migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of glial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of positive regulation of macrophage chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of positive regulation of macrophage proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of phagocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of smooth muscle cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of wound healing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within protein autophosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of cell adhesion mediated by integrin ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell adhesion mediated by integrin ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell population proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of cell shape ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell shape ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of epithelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of focal adhesion assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of modification of postsynaptic actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of modification of postsynaptic actin cytoskeleton IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of osteoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of osteoblast differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of substrate adhesion-dependent cell spreading ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in signal complex assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within vasculogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in vasodilation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell cortex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in ciliary basal body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in ciliary basal body ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    is_active_in dendritic spine IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in dendritic spine ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in focal adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in focal adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intercalated disc ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lamellipodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in sarcolemma ISO
    Inferred from Sequence Orthology
    more info
     
    located_in stress fiber ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    focal adhesion kinase 1
    Names
    focal adhesion kinase-related nonkinase
    focal ashension kinase 1
    pp125FAK
    protein-tyrosine kinase 2
    NP_001344974.1
    NP_001344975.1
    NP_032008.2
    XP_006520478.1
    XP_006520479.1
    XP_006520487.1
    XP_006520488.1
    XP_006520490.1
    XP_006520491.1
    XP_006520492.1
    XP_006520493.1
    XP_006520494.1
    XP_006520495.1
    XP_006520497.1
    XP_006520498.1
    XP_030104179.1
    XP_030104180.1
    XP_030104184.1
    XP_030104186.1
    XP_030104188.1
    XP_030104190.1
    XP_030104191.1
    XP_030104192.1
    XP_036015019.1
    XP_036015020.1
    XP_036015021.1
    XP_036015022.1
    XP_036015023.1
    XP_036015024.1
    XP_036015027.1
    XP_036015028.1
    XP_036015029.1
    XP_036015030.1
    XP_036015031.1
    XP_036015032.1
    XP_036015033.1
    XP_036015035.1
    XP_036015036.1
    XP_036015037.1
    XP_036015038.1
    XP_036015039.1
    XP_036015040.1
    XP_036015041.1
    XP_036015042.1
    XP_036015044.1
    XP_036015045.1
    XP_036015046.1
    XP_036015047.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001358045.1NP_001344974.1  focal adhesion kinase 1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains alternate exons in the 5' UTR and 3' coding region and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is longer than isoform 1.
      Source sequence(s)
      AC121319, AC132863, AC161581
      UniProtKB/TrEMBL
      A0A5F8MPY3
      Conserved Domains (5) summary
      cd05056
      Location:459728
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:80302
      B41; Band 4.1 homologues
      cd13190
      Location:298408
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9631092
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:79174
      FERM_N_2; FERM N-terminal domain
    2. NM_001358046.1NP_001344975.1  focal adhesion kinase 1 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 4, which is longer than isoform 1.
      Source sequence(s)
      AC121319, AC132863, AC161581
      UniProtKB/TrEMBL
      A0A5F8MPY3, K7Q751
      Conserved Domains (5) summary
      cd05056
      Location:428697
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9321061
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35130
      FERM_N_2; FERM N-terminal domain
    3. NM_007982.2NP_032008.2  focal adhesion kinase 1 isoform 1

      See identical proteins and their annotated locations for NP_032008.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AK220543, BB816209
      Consensus CDS
      CCDS37099.1
      UniProtKB/Swiss-Prot
      O08578, P34152, Q5DTH7, Q8C513, Q8CFH7, Q8CHM2, Q8K2S0, Q9DAW3
      UniProtKB/TrEMBL
      A0A5F8MPY3
      Related
      ENSMUSP00000105663.3, ENSMUST00000110036.11
      Conserved Domains (4) summary
      cd05056
      Location:415684
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9161045
      Focal_AT; Focal adhesion targeting region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      73076951..73297192 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036159142.1XP_036015035.1  focal adhesion kinase 1 isoform X14

      UniProtKB/TrEMBL
      A0A5F8MPY3
      Conserved Domains (5) summary
      cd05056
      Location:456725
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9601089
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35130
      FERM_N_2; FERM N-terminal domain
    2. XM_036159153.1XP_036015046.1  focal adhesion kinase 1 isoform X23

      UniProtKB/TrEMBL
      A0A5F8MPY3
      Conserved Domains (5) summary
      cd05056
      Location:314583
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:16157
      B41; Band 4.1 homologues
      cd13190
      Location:153263
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:818947
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:129
      FERM_N_2; FERM N-terminal domain
    3. XM_036159152.1XP_036015045.1  focal adhesion kinase 1 isoform X22

      UniProtKB/TrEMBL
      A0A5F8MPY3
      Conserved Domains (5) summary
      cd05056
      Location:327596
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:16157
      B41; Band 4.1 homologues
      cd13190
      Location:153263
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:831960
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:129
      FERM_N_2; FERM N-terminal domain
    4. XM_006520434.4XP_006520497.1  focal adhesion kinase 1 isoform X21

      UniProtKB/TrEMBL
      A0A5F8MPY3
      Conserved Domains (5) summary
      cd05056
      Location:355624
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:16157
      B41; Band 4.1 homologues
      cd13190
      Location:153263
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:859988
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:129
      FERM_N_2; FERM N-terminal domain
    5. XM_030248332.2XP_030104192.1  focal adhesion kinase 1 isoform X20

      UniProtKB/TrEMBL
      A0A5F8MPY3
      Conserved Domains (5) summary
      cd05056
      Location:415684
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9191048
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35130
      FERM_N_2; FERM N-terminal domain
    6. XM_036159146.1XP_036015039.1  focal adhesion kinase 1 isoform X19

      UniProtKB/TrEMBL
      A0A5F8MPY3
      Conserved Domains (5) summary
      cd05056
      Location:422691
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9261055
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35130
      FERM_N_2; FERM N-terminal domain
    7. XM_006520424.4XP_006520487.1  focal adhesion kinase 1 isoform X14

      See identical proteins and their annotated locations for XP_006520487.1

      UniProtKB/TrEMBL
      A0A5F8MPY3
      Conserved Domains (5) summary
      cd05056
      Location:456725
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9601089
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35130
      FERM_N_2; FERM N-terminal domain
    8. XM_006520416.4XP_006520479.1  focal adhesion kinase 1 isoform X1

      See identical proteins and their annotated locations for XP_006520479.1

      UniProtKB/TrEMBL
      A0A5F8MPY3
      Conserved Domains (5) summary
      cd05056
      Location:500769
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:80302
      B41; Band 4.1 homologues
      cd13190
      Location:298408
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:10041133
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:79174
      FERM_N_2; FERM N-terminal domain
    9. XM_036159149.1XP_036015042.1  focal adhesion kinase 1 isoform X20

      UniProtKB/TrEMBL
      A0A5F8MPY3
      Conserved Domains (5) summary
      cd05056
      Location:415684
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9191048
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35130
      FERM_N_2; FERM N-terminal domain
    10. XM_036159147.1XP_036015040.1  focal adhesion kinase 1 isoform X19

      UniProtKB/TrEMBL
      A0A5F8MPY3
      Conserved Domains (5) summary
      cd05056
      Location:422691
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9261055
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35130
      FERM_N_2; FERM N-terminal domain
    11. XM_036159145.1XP_036015038.1  focal adhesion kinase 1 isoform X18

      UniProtKB/TrEMBL
      A0A5F8MPY3, K7Q751
      Conserved Domains (5) summary
      cd05056
      Location:428697
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9321061
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35130
      FERM_N_2; FERM N-terminal domain
    12. XM_006520425.4XP_006520488.1  focal adhesion kinase 1 isoform X14

      See identical proteins and their annotated locations for XP_006520488.1

      UniProtKB/TrEMBL
      A0A5F8MPY3
      Conserved Domains (5) summary
      cd05056
      Location:456725
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9601089
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35130
      FERM_N_2; FERM N-terminal domain
    13. XM_006520415.4XP_006520478.1  focal adhesion kinase 1 isoform X1

      See identical proteins and their annotated locations for XP_006520478.1

      UniProtKB/TrEMBL
      A0A5F8MPY3
      Conserved Domains (5) summary
      cd05056
      Location:500769
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:80302
      B41; Band 4.1 homologues
      cd13190
      Location:298408
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:10041133
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:79174
      FERM_N_2; FERM N-terminal domain
    14. XM_006520429.4XP_006520492.1  focal adhesion kinase 1 isoform X14

      See identical proteins and their annotated locations for XP_006520492.1

      UniProtKB/TrEMBL
      A0A5F8MPY3
      Conserved Domains (5) summary
      cd05056
      Location:456725
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9601089
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35130
      FERM_N_2; FERM N-terminal domain
    15. XM_030248320.2XP_030104180.1  focal adhesion kinase 1 isoform X1

      UniProtKB/TrEMBL
      A0A5F8MPY3
      Conserved Domains (5) summary
      cd05056
      Location:500769
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:80302
      B41; Band 4.1 homologues
      cd13190
      Location:298408
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:10041133
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:79174
      FERM_N_2; FERM N-terminal domain
    16. XM_006520428.4XP_006520491.1  focal adhesion kinase 1 isoform X14

      See identical proteins and their annotated locations for XP_006520491.1

      UniProtKB/TrEMBL
      A0A5F8MPY3
      Conserved Domains (5) summary
      cd05056
      Location:456725
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9601089
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35130
      FERM_N_2; FERM N-terminal domain
    17. XM_006520427.5XP_006520490.1  focal adhesion kinase 1 isoform X14

      See identical proteins and their annotated locations for XP_006520490.1

      UniProtKB/TrEMBL
      A0A5F8MPY3
      Conserved Domains (5) summary
      cd05056
      Location:456725
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9601089
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35130
      FERM_N_2; FERM N-terminal domain
    18. XM_030248319.2XP_030104179.1  focal adhesion kinase 1 isoform X1

      UniProtKB/TrEMBL
      A0A5F8MPY3
      Conserved Domains (5) summary
      cd05056
      Location:500769
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:80302
      B41; Band 4.1 homologues
      cd13190
      Location:298408
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:10041133
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:79174
      FERM_N_2; FERM N-terminal domain
    19. XM_036159140.1XP_036015033.1  focal adhesion kinase 1 isoform X14

      UniProtKB/TrEMBL
      A0A5F8MPY3
      Conserved Domains (5) summary
      cd05056
      Location:456725
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9601089
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35130
      FERM_N_2; FERM N-terminal domain
    20. XM_030248330.2XP_030104190.1  focal adhesion kinase 1 isoform X17

      UniProtKB/TrEMBL
      A0A5F8MPY3
      Conserved Domains (5) summary
      cd05056
      Location:459728
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:80302
      B41; Band 4.1 homologues
      cd13190
      Location:298408
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9421071
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:79174
      FERM_N_2; FERM N-terminal domain
    21. XM_006520432.4XP_006520495.1  focal adhesion kinase 1 isoform X15

      UniProtKB/TrEMBL
      A0A5F8MPY3
      Conserved Domains (5) summary
      cd05056
      Location:459728
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:80302
      B41; Band 4.1 homologues
      cd13190
      Location:298408
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9601089
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:79174
      FERM_N_2; FERM N-terminal domain
    22. XM_036159139.1XP_036015032.1  focal adhesion kinase 1 isoform X13

      UniProtKB/TrEMBL
      A0A5F8MPY3
      Conserved Domains (5) summary
      cd05056
      Location:459728
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:80302
      B41; Band 4.1 homologues
      cd13190
      Location:298408
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9631092
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:79174
      FERM_N_2; FERM N-terminal domain
    23. XM_036159138.1XP_036015031.1  focal adhesion kinase 1 isoform X11

      UniProtKB/TrEMBL
      A0A5F8MPY3
      Conserved Domains (5) summary
      cd05056
      Location:466735
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:80302
      B41; Band 4.1 homologues
      cd13190
      Location:298408
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9671096
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:79174
      FERM_N_2; FERM N-terminal domain
    24. XM_036159136.1XP_036015029.1  focal adhesion kinase 1 isoform X9

      UniProtKB/TrEMBL
      A0A5F8MPY3
      Conserved Domains (5) summary
      cd05056
      Location:466735
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:80302
      B41; Band 4.1 homologues
      cd13190
      Location:298408
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9701099
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:79174
      FERM_N_2; FERM N-terminal domain
    25. XM_030248326.2XP_030104186.1  focal adhesion kinase 1 isoform X12

      UniProtKB/TrEMBL
      A0A5F8MPY3
      Conserved Domains (5) summary
      cd05056
      Location:465734
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:80302
      B41; Band 4.1 homologues
      cd13190
      Location:298408
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9661095
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:79174
      FERM_N_2; FERM N-terminal domain
    26. XM_036159137.1XP_036015030.1  focal adhesion kinase 1 isoform X10

      UniProtKB/TrEMBL
      A0A5F8MPY3
      Conserved Domains (5) summary
      cd05056
      Location:465734
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:80302
      B41; Band 4.1 homologues
      cd13190
      Location:298408
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9691098
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:79174
      FERM_N_2; FERM N-terminal domain
    27. XM_036159144.1XP_036015037.1  focal adhesion kinase 1 isoform X16

      UniProtKB/TrEMBL
      A0A5F8MPY3
      Conserved Domains (5) summary
      cd05056
      Location:472741
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:80302
      B41; Band 4.1 homologues
      cd13190
      Location:298408
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9551084
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:79174
      FERM_N_2; FERM N-terminal domain
    28. XM_036159135.1XP_036015028.1  focal adhesion kinase 1 isoform X7

      UniProtKB/TrEMBL
      A0A5F8MPY3
      Conserved Domains (5) summary
      cd05056
      Location:472741
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:80302
      B41; Band 4.1 homologues
      cd13190
      Location:298408
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9761105
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:79174
      FERM_N_2; FERM N-terminal domain
    29. XM_030248324.2XP_030104184.1  focal adhesion kinase 1 isoform X8

      UniProtKB/TrEMBL
      A0A5F8MPY3
      Conserved Domains (5) summary
      cd05056
      Location:493762
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:80302
      B41; Band 4.1 homologues
      cd13190
      Location:298408
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9731102
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:79174
      FERM_N_2; FERM N-terminal domain
    30. XM_036159130.1XP_036015023.1  focal adhesion kinase 1 isoform X4

      UniProtKB/TrEMBL
      A0A5F8MPY3
      Conserved Domains (5) summary
      cd05056
      Location:493762
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:80302
      B41; Band 4.1 homologues
      cd13190
      Location:298408
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9941123
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:79174
      FERM_N_2; FERM N-terminal domain
    31. XM_036159129.1XP_036015022.1  focal adhesion kinase 1 isoform X3

      UniProtKB/TrEMBL
      A0A5F8MPY3
      Conserved Domains (5) summary
      cd05056
      Location:493762
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:80302
      B41; Band 4.1 homologues
      cd13190
      Location:298408
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9971126
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:79174
      FERM_N_2; FERM N-terminal domain
    32. XM_036159134.1XP_036015027.1  focal adhesion kinase 1 isoform X6

      UniProtKB/TrEMBL
      A0A5F8MPY3
      Conserved Domains (5) summary
      cd05056
      Location:500769
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:80302
      B41; Band 4.1 homologues
      cd13190
      Location:298408
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9801109
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:79174
      FERM_N_2; FERM N-terminal domain
    33. XM_036159131.1XP_036015024.1  focal adhesion kinase 1 isoform X5

      UniProtKB/TrEMBL
      A0A5F8MPY3
      Conserved Domains (5) summary
      cd05056
      Location:500769
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:80302
      B41; Band 4.1 homologues
      cd13190
      Location:298408
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9831112
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:79174
      FERM_N_2; FERM N-terminal domain
    34. XM_036159128.1XP_036015021.1  focal adhesion kinase 1 isoform X2

      UniProtKB/TrEMBL
      A0A5F8MPY3
      Conserved Domains (5) summary
      cd05056
      Location:500769
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:80302
      B41; Band 4.1 homologues
      cd13190
      Location:298408
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:10011130
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:79174
      FERM_N_2; FERM N-terminal domain
    35. XM_036159126.1XP_036015019.1  focal adhesion kinase 1 isoform X1

      UniProtKB/TrEMBL
      A0A5F8MPY3
      Conserved Domains (5) summary
      cd05056
      Location:500769
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:80302
      B41; Band 4.1 homologues
      cd13190
      Location:298408
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:10041133
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:79174
      FERM_N_2; FERM N-terminal domain
    36. XM_030248328.2XP_030104188.1  focal adhesion kinase 1 isoform X14

      UniProtKB/TrEMBL
      A0A5F8MPY3
      Conserved Domains (5) summary
      cd05056
      Location:456725
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9601089
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35130
      FERM_N_2; FERM N-terminal domain
    37. XM_036159127.1XP_036015020.1  focal adhesion kinase 1 isoform X1

      UniProtKB/TrEMBL
      A0A5F8MPY3
      Conserved Domains (5) summary
      cd05056
      Location:500769
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:80302
      B41; Band 4.1 homologues
      cd13190
      Location:298408
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:10041133
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:79174
      FERM_N_2; FERM N-terminal domain
    38. XM_006520430.2XP_006520493.1  focal adhesion kinase 1 isoform X14

      See identical proteins and their annotated locations for XP_006520493.1

      UniProtKB/TrEMBL
      A0A5F8MPY3
      Conserved Domains (5) summary
      cd05056
      Location:456725
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9601089
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35130
      FERM_N_2; FERM N-terminal domain
    39. XM_006520431.2XP_006520494.1  focal adhesion kinase 1 isoform X14

      See identical proteins and their annotated locations for XP_006520494.1

      UniProtKB/TrEMBL
      A0A5F8MPY3
      Conserved Domains (5) summary
      cd05056
      Location:456725
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9601089
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35130
      FERM_N_2; FERM N-terminal domain
    40. XM_036159151.1XP_036015044.1  focal adhesion kinase 1 isoform X21

      UniProtKB/TrEMBL
      A0A5F8MPY3
      Conserved Domains (5) summary
      cd05056
      Location:355624
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:16157
      B41; Band 4.1 homologues
      cd13190
      Location:153263
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:859988
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:129
      FERM_N_2; FERM N-terminal domain
    41. XM_006520435.5XP_006520498.1  focal adhesion kinase 1 isoform X14

      See identical proteins and their annotated locations for XP_006520498.1

      UniProtKB/TrEMBL
      A0A5F8MPY3
      Related
      ENSMUSP00000159174.2, ENSMUST00000239146.2
      Conserved Domains (5) summary
      cd05056
      Location:456725
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9601089
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35130
      FERM_N_2; FERM N-terminal domain
    42. XM_036159148.1XP_036015041.1  focal adhesion kinase 1 isoform X19

      UniProtKB/TrEMBL
      A0A5F8MPY3
      Conserved Domains (5) summary
      cd05056
      Location:422691
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9261055
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35130
      FERM_N_2; FERM N-terminal domain
    43. XM_030248331.1XP_030104191.1  focal adhesion kinase 1 isoform X20

      UniProtKB/TrEMBL
      A0A5F8MPY3
      Related
      ENSMUSP00000154242.2, ENSMUST00000226988.3
      Conserved Domains (5) summary
      cd05056
      Location:415684
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9191048
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35130
      FERM_N_2; FERM N-terminal domain
    44. XM_036159143.1XP_036015036.1  focal adhesion kinase 1 isoform X14

      UniProtKB/TrEMBL
      A0A5F8MPY3
      Conserved Domains (5) summary
      cd05056
      Location:456725
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9601089
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35130
      FERM_N_2; FERM N-terminal domain
    45. XM_036159154.1XP_036015047.1  focal adhesion kinase 1 isoform X24

      Conserved Domains (1) summary
      pfam03623
      Location:229358
      Focal_AT; Focal adhesion targeting region

    RNA

    1. XR_004938793.1 RNA Sequence

    2. XR_003951347.2 RNA Sequence

    3. XR_004938792.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001130409.1: Suppressed sequence

      Description
      NM_001130409.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.