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    Ptk2 PTK2 protein tyrosine kinase 2 [ Mus musculus (house mouse) ]

    Gene ID: 14083, updated on 10-Nov-2018

    Summary

    Official Symbol
    Ptk2provided by MGI
    Official Full Name
    PTK2 protein tyrosine kinase 2provided by MGI
    Primary source
    MGI:MGI:95481
    See related
    Ensembl:ENSMUSG00000022607
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    FAK; FRNK; Fadk; FADK 1; p125FAK
    Expression
    Ubiquitous expression in cortex adult (RPKM 12.3), CNS E11.5 (RPKM 11.8) and 28 other tissues See more
    Orthologs

    Genomic context

    See Ptk2 in Genome Data Viewer
    Location:
    15 D3; 15 33.94 cM
    Exon count:
    41
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 15 NC_000081.6 (73205102..73423275, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (73035535..73253621, complement)

    Chromosome 15 - NC_000081.6Genomic Context describing neighboring genes Neighboring gene chromatin accessibility complex 1 Neighboring gene predicted gene, 31725 Neighboring gene argonaute RISC catalytic subunit 2 Neighboring gene microRNA 151 Neighboring gene predicted gene, 41344 Neighboring gene protein tyrosine phosphatase-like (proline instead of catalytic arginine), member b pseudogene Neighboring gene ribosomal protein L17 pseudogene Neighboring gene cytochrome b-c1 complex subunit 6, mitochondrial pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA4203

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    JUN kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    SH2 domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    actin binding ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    integrin binding ISO
    Inferred from Sequence Orthology
    more info
     
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    non-membrane spanning protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    non-membrane spanning protein tyrosine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    non-membrane spanning protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
     
    phosphatidylinositol 3-kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein tyrosine kinase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    JNK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    blood vessel development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cellular chloride ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to transforming growth factor beta stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    central nervous system neuron axonogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    endothelial cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ephrin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    epidermal growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    extracellular matrix organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    growth hormone receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    integrin-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    integrin-mediated signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    microtubule cytoskeleton organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    movement of cell or subcellular component TAS
    Traceable Author Statement
    more info
    PubMed 
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of anoikis ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of autophagy IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of autophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of axonogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of organ growth IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of synapse assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neuron migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuron migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    nuclear migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peptidyl-tyrosine autophosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    peptidyl-tyrosine autophosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peptidyl-tyrosine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of blood vessel diameter ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cardiac muscle hypertrophy IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of glial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of phagocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of phosphatidylinositol 3-kinase signaling ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein kinase B signaling ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of smooth muscle cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein autophosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of cell adhesion mediated by integrin ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell shape ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of epithelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of focal adhesion assembly ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of osteoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of substrate adhesion-dependent cell spreading ISO
    Inferred from Sequence Orthology
    more info
     
    signal complex assembly IEA
    Inferred from Electronic Annotation
    more info
     
    transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    vasculogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    dendritic spine IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    dendritic spine ISO
    Inferred from Sequence Orthology
    more info
     
    focal adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    focal adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    focal adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    intercalated disc ISO
    Inferred from Sequence Orthology
    more info
     
    lamellipodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    postsynapse ISO
    Inferred from Sequence Orthology
    more info
     
    sarcolemma ISO
    Inferred from Sequence Orthology
    more info
     
    stress fiber ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    focal adhesion kinase 1
    Names
    focal adhesion kinase-related nonkinase
    focal ashension kinase 1
    pp125FAK
    protein-tyrosine kinase 2
    NP_032008.2
    XP_006520478.1
    XP_006520479.1
    XP_006520481.1
    XP_006520483.1
    XP_006520484.1
    XP_006520485.1
    XP_006520486.1
    XP_006520487.1
    XP_006520488.1
    XP_006520489.1
    XP_006520490.1
    XP_006520491.1
    XP_006520492.1
    XP_006520493.1
    XP_006520494.1
    XP_006520495.1
    XP_006520496.1
    XP_006520497.1
    XP_006520498.1
    XP_011243754.1
    XP_011243755.1
    XP_017171917.1
    XP_017171918.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001358045.1NP_001344974.1  focal adhesion kinase 1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains alternate exons in the 5' UTR and 3' coding region and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is longer than isoform 1.
      Source sequence(s)
      AC121319, AC132863, AC161581
    2. NM_001358046.1NP_001344975.1  focal adhesion kinase 1 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 4, which is longer than isoform 1.
      Source sequence(s)
      AC121319, AC132863, AC161581
      Conserved Domains (4) summary
      cd05056
      Location:428697
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9321061
      Focal_AT; Focal adhesion targeting region
    3. NM_007982.2NP_032008.2  focal adhesion kinase 1 isoform 1

      See identical proteins and their annotated locations for NP_032008.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AK220543, BB816209
      Consensus CDS
      CCDS37099.1
      UniProtKB/Swiss-Prot
      P34152
      Related
      ENSMUSP00000105663.2, ENSMUST00000110036.10
      Conserved Domains (6) summary
      cd05056
      Location:415684
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      cd14473
      Location:143248
      FERM_B-lobe; FERM domain B-lobe
      pfam03623
      Location:9161045
      Focal_AT; Focal adhesion targeting region
      pfam07714
      Location:422676
      Pkinase_Tyr; Protein tyrosine kinase

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000081.6 Reference GRCm38.p4 C57BL/6J

      Range
      73205102..73423275 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006520426.2XP_006520489.1  focal adhesion kinase 1 isoform X9

      See identical proteins and their annotated locations for XP_006520489.1

      Conserved Domains (6) summary
      cd05056
      Location:456725
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      cd14473
      Location:143248
      FERM_B-lobe; FERM domain B-lobe
      pfam03623
      Location:9601089
      Focal_AT; Focal adhesion targeting region
      pfam07714
      Location:463717
      Pkinase_Tyr; Protein tyrosine kinase
    2. XM_006520430.2XP_006520493.1  focal adhesion kinase 1 isoform X9

      See identical proteins and their annotated locations for XP_006520493.1

      Conserved Domains (6) summary
      cd05056
      Location:456725
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      cd14473
      Location:143248
      FERM_B-lobe; FERM domain B-lobe
      pfam03623
      Location:9601089
      Focal_AT; Focal adhesion targeting region
      pfam07714
      Location:463717
      Pkinase_Tyr; Protein tyrosine kinase
    3. XM_006520431.2XP_006520494.1  focal adhesion kinase 1 isoform X9

      See identical proteins and their annotated locations for XP_006520494.1

      Conserved Domains (6) summary
      cd05056
      Location:456725
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      cd14473
      Location:143248
      FERM_B-lobe; FERM domain B-lobe
      pfam03623
      Location:9601089
      Focal_AT; Focal adhesion targeting region
      pfam07714
      Location:463717
      Pkinase_Tyr; Protein tyrosine kinase
    4. XM_006520435.3XP_006520498.1  focal adhesion kinase 1 isoform X9

      See identical proteins and their annotated locations for XP_006520498.1

      Conserved Domains (6) summary
      cd05056
      Location:456725
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      cd14473
      Location:143248
      FERM_B-lobe; FERM domain B-lobe
      pfam03623
      Location:9601089
      Focal_AT; Focal adhesion targeting region
      pfam07714
      Location:463717
      Pkinase_Tyr; Protein tyrosine kinase
    5. XM_006520424.2XP_006520487.1  focal adhesion kinase 1 isoform X9

      See identical proteins and their annotated locations for XP_006520487.1

      Conserved Domains (6) summary
      cd05056
      Location:456725
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      cd14473
      Location:143248
      FERM_B-lobe; FERM domain B-lobe
      pfam03623
      Location:9601089
      Focal_AT; Focal adhesion targeting region
      pfam07714
      Location:463717
      Pkinase_Tyr; Protein tyrosine kinase
    6. XM_006520416.2XP_006520479.1  focal adhesion kinase 1 isoform X1

      See identical proteins and their annotated locations for XP_006520479.1

      Conserved Domains (6) summary
      cd05056
      Location:500769
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:80302
      B41; Band 4.1 homologues
      cd13190
      Location:298408
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      cd14473
      Location:187292
      FERM_B-lobe; FERM domain B-lobe
      pfam03623
      Location:10041133
      Focal_AT; Focal adhesion targeting region
      pfam07714
      Location:507761
      Pkinase_Tyr; Protein tyrosine kinase
    7. XM_006520425.2XP_006520488.1  focal adhesion kinase 1 isoform X9

      See identical proteins and their annotated locations for XP_006520488.1

      Conserved Domains (6) summary
      cd05056
      Location:456725
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      cd14473
      Location:143248
      FERM_B-lobe; FERM domain B-lobe
      pfam03623
      Location:9601089
      Focal_AT; Focal adhesion targeting region
      pfam07714
      Location:463717
      Pkinase_Tyr; Protein tyrosine kinase
    8. XM_006520415.2XP_006520478.1  focal adhesion kinase 1 isoform X1

      See identical proteins and their annotated locations for XP_006520478.1

      Conserved Domains (6) summary
      cd05056
      Location:500769
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:80302
      B41; Band 4.1 homologues
      cd13190
      Location:298408
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      cd14473
      Location:187292
      FERM_B-lobe; FERM domain B-lobe
      pfam03623
      Location:10041133
      Focal_AT; Focal adhesion targeting region
      pfam07714
      Location:507761
      Pkinase_Tyr; Protein tyrosine kinase
    9. XM_006520429.2XP_006520492.1  focal adhesion kinase 1 isoform X9

      See identical proteins and their annotated locations for XP_006520492.1

      Conserved Domains (6) summary
      cd05056
      Location:456725
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      cd14473
      Location:143248
      FERM_B-lobe; FERM domain B-lobe
      pfam03623
      Location:9601089
      Focal_AT; Focal adhesion targeting region
      pfam07714
      Location:463717
      Pkinase_Tyr; Protein tyrosine kinase
    10. XM_006520428.2XP_006520491.1  focal adhesion kinase 1 isoform X9

      See identical proteins and their annotated locations for XP_006520491.1

      Conserved Domains (6) summary
      cd05056
      Location:456725
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      cd14473
      Location:143248
      FERM_B-lobe; FERM domain B-lobe
      pfam03623
      Location:9601089
      Focal_AT; Focal adhesion targeting region
      pfam07714
      Location:463717
      Pkinase_Tyr; Protein tyrosine kinase
    11. XM_006520427.3XP_006520490.1  focal adhesion kinase 1 isoform X9

      See identical proteins and their annotated locations for XP_006520490.1

      Conserved Domains (6) summary
      cd05056
      Location:456725
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      cd14473
      Location:143248
      FERM_B-lobe; FERM domain B-lobe
      pfam03623
      Location:9601089
      Focal_AT; Focal adhesion targeting region
      pfam07714
      Location:463717
      Pkinase_Tyr; Protein tyrosine kinase
    12. XM_006520434.2XP_006520497.1  focal adhesion kinase 1 isoform X13

      Conserved Domains (6) summary
      cd05056
      Location:355624
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:16157
      B41; Band 4.1 homologues
      cd13190
      Location:153263
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      cd14473
      Location:42147
      FERM_B-lobe; FERM domain B-lobe
      pfam03623
      Location:859988
      Focal_AT; Focal adhesion targeting region
      pfam07714
      Location:362616
      Pkinase_Tyr; Protein tyrosine kinase
    13. XM_017316429.1XP_017171918.1  focal adhesion kinase 1 isoform X11

      UniProtKB/TrEMBL
      K7Q751
      Conserved Domains (4) summary
      cd05056
      Location:428697
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9321061
      Focal_AT; Focal adhesion targeting region
    14. XM_006520433.2XP_006520496.1  focal adhesion kinase 1 isoform X12

      UniProtKB/Swiss-Prot
      P34152
      Related
      ENSMUSP00000154242.1, ENSMUST00000226988.2
      Conserved Domains (6) summary
      cd05056
      Location:415684
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      cd14473
      Location:143248
      FERM_B-lobe; FERM domain B-lobe
      pfam03623
      Location:9191048
      Focal_AT; Focal adhesion targeting region
      pfam07714
      Location:422676
      Pkinase_Tyr; Protein tyrosine kinase
    15. XM_006520423.1XP_006520486.1  focal adhesion kinase 1 isoform X8

      Conserved Domains (4) summary
      cd05056
      Location:459728
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:80302
      B41; Band 4.1 homologues
      cd13190
      Location:298408
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9631092
      Focal_AT; Focal adhesion targeting region
    16. XM_006520422.1XP_006520485.1  focal adhesion kinase 1 isoform X8

      See identical proteins and their annotated locations for XP_006520485.1

      Conserved Domains (4) summary
      cd05056
      Location:459728
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:80302
      B41; Band 4.1 homologues
      cd13190
      Location:298408
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9631092
      Focal_AT; Focal adhesion targeting region
    17. XM_006520421.1XP_006520484.1  focal adhesion kinase 1 isoform X6

      Conserved Domains (6) summary
      cd05056
      Location:466735
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:80302
      B41; Band 4.1 homologues
      cd13190
      Location:298408
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      cd14473
      Location:187292
      FERM_B-lobe; FERM domain B-lobe
      pfam03623
      Location:9701099
      Focal_AT; Focal adhesion targeting region
      pfam07714
      Location:473727
      Pkinase_Tyr; Protein tyrosine kinase
    18. XM_006520420.1XP_006520483.1  focal adhesion kinase 1 isoform X5

      Conserved Domains (6) summary
      cd05056
      Location:472741
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:80302
      B41; Band 4.1 homologues
      cd13190
      Location:298408
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      cd14473
      Location:187292
      FERM_B-lobe; FERM domain B-lobe
      pfam03623
      Location:9761105
      Focal_AT; Focal adhesion targeting region
      pfam07714
      Location:479733
      Pkinase_Tyr; Protein tyrosine kinase
    19. XM_006520418.1XP_006520481.1  focal adhesion kinase 1 isoform X3

      Conserved Domains (6) summary
      cd05056
      Location:493762
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:80302
      B41; Band 4.1 homologues
      cd13190
      Location:298408
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      cd14473
      Location:187292
      FERM_B-lobe; FERM domain B-lobe
      pfam03623
      Location:9971126
      Focal_AT; Focal adhesion targeting region
      pfam07714
      Location:500754
      Pkinase_Tyr; Protein tyrosine kinase
    20. XM_011245453.1XP_011243755.1  focal adhesion kinase 1 isoform X4

      Conserved Domains (6) summary
      cd05056
      Location:500769
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:80302
      B41; Band 4.1 homologues
      cd13190
      Location:298408
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      cd14473
      Location:187292
      FERM_B-lobe; FERM domain B-lobe
      pfam03623
      Location:9831112
      Focal_AT; Focal adhesion targeting region
      pfam07714
      Location:507761
      Pkinase_Tyr; Protein tyrosine kinase
    21. XM_006520432.2XP_006520495.1  focal adhesion kinase 1 isoform X10

      Conserved Domains (6) summary
      cd05056
      Location:459728
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:80302
      B41; Band 4.1 homologues
      cd13190
      Location:298408
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      cd14473
      Location:187292
      FERM_B-lobe; FERM domain B-lobe
      pfam03623
      Location:9601089
      Focal_AT; Focal adhesion targeting region
      pfam07714
      Location:466720
      Pkinase_Tyr; Protein tyrosine kinase
    22. XM_017316428.1XP_017171917.1  focal adhesion kinase 1 isoform X7

    23. XM_011245452.2XP_011243754.1  focal adhesion kinase 1 isoform X2

      Conserved Domains (6) summary
      cd05056
      Location:500769
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:80302
      B41; Band 4.1 homologues
      cd13190
      Location:298408
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      cd14473
      Location:187292
      FERM_B-lobe; FERM domain B-lobe
      pfam03623
      Location:10011130
      Focal_AT; Focal adhesion targeting region
      pfam07714
      Location:507761
      Pkinase_Tyr; Protein tyrosine kinase

    RNA

    1. XR_383981.2 RNA Sequence

    2. XR_001781493.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001130409.1: Suppressed sequence

      Description
      NM_001130409.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
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