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    Acsl1 acyl-CoA synthetase long-chain family member 1 [ Mus musculus (house mouse) ]

    Gene ID: 14081, updated on 31-Jan-2019

    Summary

    Official Symbol
    Acsl1provided by MGI
    Official Full Name
    acyl-CoA synthetase long-chain family member 1provided by MGI
    Primary source
    MGI:MGI:102797
    See related
    Ensembl:ENSMUSG00000018796
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Acs; Acas; FACS; Acas1; Facl2; LACS1; LACS 1
    Summary
    The protein encoded by this gene belongs to a family of acyl coenzyme A synthetase proteins, which convert long chain fatty acids to acyl CoA products via an ATP-dependent pathway. This enzyme is enriched in heart, liver and adipose tissue, where it functions in lipid synthesis and mitochondrial and peroxisomal beta-oxidation. In addition, it is expressed in monocytes and macrophages where it appears to have a functionally distinct role in mediating inflammatory and innate immune responses. A pseudogene of this gene is found on chromosome 5. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
    Expression
    Biased expression in liver E18 (RPKM 94.6), subcutaneous fat pad adult (RPKM 79.5) and 13 other tissues See more
    Orthologs

    Genomic context

    See Acsl1 in Genome Data Viewer
    Location:
    8; 8 B1.1
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 8 NC_000074.6 (46471037..46536051)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (47556396..47621404)

    Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 30931 Neighboring gene predicted gene, 31050 Neighboring gene centromere protein U Neighboring gene primase and polymerase (DNA-directed) Neighboring gene caspase 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    acetate-CoA ligase (ADP-forming) activity IEA
    Inferred from Electronic Annotation
    more info
     
    catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    decanoate-CoA ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    long-chain fatty acid-CoA ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    adiponectin-activated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    fatty acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    fatty acid transport ISO
    Inferred from Sequence Orthology
    more info
     
    lipid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    long-chain fatty acid import ISO
    Inferred from Sequence Orthology
    more info
     
    long-chain fatty acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    long-chain fatty-acyl-CoA biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cold-induced thermogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein serine/threonine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to organic substance ISO
    Inferred from Sequence Orthology
    more info
     
    triglyceride biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    xenobiotic catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion HDA PubMed 
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    peroxisomal membrane ISO
    Inferred from Sequence Orthology
    more info
     
    peroxisome IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    long-chain-fatty-acid--CoA ligase 1
    Names
    acetate-CoA ligase
    acetyl-CoA synthetase
    acetyl-Coenzyme A synthetase 1 (ADP forming)
    fatty acid Coenzyme A ligase, long chain 2
    long-chain acyl-CoA synthetase 1
    NP_001289092.1
    NP_032007.2
    XP_006509325.2
    XP_006509327.1
    XP_006509328.1
    XP_006509329.1
    XP_017168052.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001302163.1NP_001289092.1  long-chain-fatty-acid--CoA ligase 1

      See identical proteins and their annotated locations for NP_001289092.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript.
      Source sequence(s)
      AC138367, AK149406, BY094311, BY142492, BY393025
      Consensus CDS
      CCDS22291.1
      UniProtKB/Swiss-Prot
      P41216
      Related
      ENSMUSP00000106001.1, ENSMUST00000110372.8
      Conserved Domains (2) summary
      PLN02736
      Location:87697
      PLN02736; long-chain acyl-CoA synthetase
      cd05927
      Location:117694
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
    2. NM_007981.4NP_032007.2  long-chain-fatty-acid--CoA ligase 1

      See identical proteins and their annotated locations for NP_032007.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has a distinct 5' UTR and represents use of an alternate promoter compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC138367, AK149406, BY393025, BY786934
      Consensus CDS
      CCDS22291.1
      UniProtKB/Swiss-Prot
      P41216
      Related
      ENSMUSP00000034046.5, ENSMUST00000034046.12
      Conserved Domains (2) summary
      PLN02736
      Location:87697
      PLN02736; long-chain acyl-CoA synthetase
      cd05927
      Location:117694
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000074.6 Reference GRCm38.p4 C57BL/6J

      Range
      46471037..46536051
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006509264.3XP_006509327.1  long-chain-fatty-acid--CoA ligase 1 isoform X1

      See identical proteins and their annotated locations for XP_006509327.1

      UniProtKB/Swiss-Prot
      P41216
      Conserved Domains (2) summary
      PLN02736
      Location:87697
      PLN02736; long-chain acyl-CoA synthetase
      cd05927
      Location:117694
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
    2. XM_017312563.1XP_017168052.1  long-chain-fatty-acid--CoA ligase 1 isoform X1

      UniProtKB/Swiss-Prot
      P41216
      Related
      ENSMUSP00000106000.1, ENSMUST00000110371.7
      Conserved Domains (2) summary
      PLN02736
      Location:87697
      PLN02736; long-chain acyl-CoA synthetase
      cd05927
      Location:117694
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
    3. XM_006509266.2XP_006509329.1  long-chain-fatty-acid--CoA ligase 1 isoform X1

      See identical proteins and their annotated locations for XP_006509329.1

      UniProtKB/Swiss-Prot
      P41216
      Conserved Domains (2) summary
      PLN02736
      Location:87697
      PLN02736; long-chain acyl-CoA synthetase
      cd05927
      Location:117694
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
    4. XM_006509265.2XP_006509328.1  long-chain-fatty-acid--CoA ligase 1 isoform X1

      See identical proteins and their annotated locations for XP_006509328.1

      UniProtKB/Swiss-Prot
      P41216
      Conserved Domains (2) summary
      PLN02736
      Location:87697
      PLN02736; long-chain acyl-CoA synthetase
      cd05927
      Location:117694
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
    5. XM_006509262.3XP_006509325.2  long-chain-fatty-acid--CoA ligase 1 isoform X1

      See identical proteins and their annotated locations for XP_006509325.2

      UniProtKB/Swiss-Prot
      P41216
      Conserved Domains (2) summary
      PLN02736
      Location:87697
      PLN02736; long-chain acyl-CoA synthetase
      cd05927
      Location:117694
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
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