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    TMEM37 transmembrane protein 37 [ Homo sapiens (human) ]

    Gene ID: 140738, updated on 21-Dec-2019

    Summary

    Official Symbol
    TMEM37provided by HGNC
    Official Full Name
    transmembrane protein 37provided by HGNC
    Primary source
    HGNC:HGNC:18216
    See related
    Ensembl:ENSG00000171227
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PR; PR1
    Expression
    Broad expression in kidney (RPKM 36.6), fat (RPKM 26.3) and 17 other tissues See more
    Orthologs

    Genomic context

    See TMEM37 in Genome Data Viewer
    Location:
    2q14.2
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    109.20191205 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (119429912..119438507)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (120187501..120196096)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene chromosome 2 open reading frame 76 Neighboring gene diazepam binding inhibitor, acyl-CoA binding protein Neighboring gene uncharacterized LOC107105282 Neighboring gene secretin receptor Neighboring gene VISTA enhancer hs1941 Neighboring gene cilia and flagella associated protein 221

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat 47-59 peptide downregulates gene expression of transmembrane protein 37 (TMEM37) in U-937 macrophages PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    calcium channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    voltage-gated ion channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    voltage-dependent calcium channel gamma-like subunit
    Names
    neuronal voltage-gated calcium channel gamma-like subunit
    voltage-dependent calcium channel gamma subunit-like protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_183240.3NP_899063.2  voltage-dependent calcium channel gamma-like subunit

      See identical proteins and their annotated locations for NP_899063.2

      Status: VALIDATED

      Source sequence(s)
      AC013275, DR003856, DR005637
      Consensus CDS
      CCDS33281.1
      UniProtKB/Swiss-Prot
      Q8WXS4
      Related
      ENSP00000303148.4, ENST00000306406.5
      Conserved Domains (1) summary
      pfam15108
      Location:8187
      TMEM37; Voltage-dependent calcium channel gamma-like subunit protein family

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

      Range
      119429912..119438507
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011510659.2XP_011508961.1  voltage-dependent calcium channel gamma-like subunit isoform X1

      UniProtKB/TrEMBL
      E7EMC0
      Related
      ENSP00000387015.1, ENST00000409826.1
      Conserved Domains (1) summary
      pfam15108
      Location:20199
      TMEM37; Voltage-dependent calcium channel gamma-like subunit protein family
    2. XM_005263598.4XP_005263655.1  voltage-dependent calcium channel gamma-like subunit isoform X2

      See identical proteins and their annotated locations for XP_005263655.1

      UniProtKB/TrEMBL
      Q86SV2
      Conserved Domains (1) summary
      pfam15108
      Location:1100
      TMEM37; Voltage-dependent calcium channel gamma-like subunit protein family
    3. XM_006712300.3XP_006712363.1  voltage-dependent calcium channel gamma-like subunit isoform X2

      See identical proteins and their annotated locations for XP_006712363.1

      UniProtKB/TrEMBL
      Q86SV2
      Conserved Domains (1) summary
      pfam15108
      Location:1100
      TMEM37; Voltage-dependent calcium channel gamma-like subunit protein family
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