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    Faah fatty acid amide hydrolase [ Mus musculus (house mouse) ]

    Gene ID: 14073, updated on 4-Jun-2024

    Summary

    Official Symbol
    Faahprovided by MGI
    Official Full Name
    fatty acid amide hydrolaseprovided by MGI
    Primary source
    MGI:MGI:109609
    See related
    Ensembl:ENSMUSG00000034171 AllianceGenome:MGI:109609
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables acylglycerol lipase activity. Predicted to be involved in fatty acid catabolic process; monoacylglycerol catabolic process; and positive regulation of vasoconstriction. Predicted to act upstream of or within lipid catabolic process. Predicted to be located in organelle membrane. Is expressed in several structures, including alimentary system; brain; ganglia; olfactory epithelium; and renal calyx. Human ortholog(s) of this gene implicated in obesity and substance-related disorder. Orthologous to human FAAH (fatty acid amide hydrolase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in liver adult (RPKM 30.1), duodenum adult (RPKM 29.3) and 22 other tissues See more
    Orthologs
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    Genomic context

    See Faah in Genome Data Viewer
    Location:
    4 D1; 4 53.08 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (115853866..115876034, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (115996668..116018837, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene diencephalon/mesencephalon homeobox 1 Neighboring gene STARR-seq mESC enhancer starr_11128 Neighboring gene predicted gene, 38492 Neighboring gene STARR-seq mESC enhancer starr_11131 Neighboring gene NOL1/NOP2/Sun domain family, member 4 Neighboring gene STARR-positive B cell enhancer ABC_E3503 Neighboring gene predicted gene 12854 Neighboring gene ubiquinol-cytochrome c reductase hinge protein

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables acylglycerol lipase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables acylglycerol lipase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables amidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables amidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables fatty acid amide hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables fatty acid amide hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity, acting on ester bonds ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables lipid binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phospholipid binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in glutamatergic synapse EXP
    Inferred from Experiment
    more info
    PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in organelle membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    fatty-acid amide hydrolase 1
    Names
    amide hydrolase
    anandamide amidohydrolase 1
    fatty acid amide hydrolase protein
    fatty acid ester hydrolase
    oleamide hydrolase 1
    NP_034303.3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010173.6NP_034303.3  fatty-acid amide hydrolase 1

      See identical proteins and their annotated locations for NP_034303.3

      Status: VALIDATED

      Source sequence(s)
      AL627105
      Consensus CDS
      CCDS18501.1
      UniProtKB/Swiss-Prot
      O08914, Q922S0, Q9DBF5
      UniProtKB/TrEMBL
      Q8C541
      Related
      ENSMUSP00000041543.5, ENSMUST00000049095.6
      Conserved Domains (1) summary
      pfam01425
      Location:95562
      Amidase; Amidase

    RNA

    1. NR_151700.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL627105
    2. NR_185205.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL627105

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      115853866..115876034 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_001784090.2 RNA Sequence

    2. XR_001784089.2 RNA Sequence