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    Caskin2 CASK-interacting protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 140721, updated on 31-Jan-2019

    Summary

    Official Symbol
    Caskin2provided by MGI
    Official Full Name
    CASK-interacting protein 2provided by MGI
    Primary source
    MGI:MGI:2157062
    See related
    Ensembl:ENSMUSG00000034471
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA1139; 1600028L06Rik
    Expression
    Broad expression in adrenal adult (RPKM 50.9), lung adult (RPKM 48.5) and 27 other tissues See more
    Orthologs

    Genomic context

    See Caskin2 in Genome Data Viewer
    Location:
    11; 11 E2
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (115798987..115813592, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (115660666..115674906, complement)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene transmembrane protein 94 Neighboring gene predicted gene, 46302 Neighboring gene microRNA 5621 Neighboring gene tRNA splicing endonuclease subunit 54 Neighboring gene LLGL2 scribble cell polarity complex component

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    molecular_function ND
    No biological Data available
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_080643.2NP_542374.2  caskin-2

      See identical proteins and their annotated locations for NP_542374.2

      Status: VALIDATED

      Source sequence(s)
      BC053083
      Consensus CDS
      CCDS25647.1
      UniProtKB/Swiss-Prot
      Q8VHK1
      Related
      ENSMUSP00000041328.4, ENSMUST00000041684.10
      Conserved Domains (10) summary
      cd09497
      Location:487552
      SAM_caskin1,2_repeat1; SAM domain of caskin protein repeat 1
      cd09498
      Location:553623
      SAM_caskin1,2_repeat2; SAM domain of caskin protein repeat 2
      smart00454
      Location:561620
      SAM; Sterile alpha motif
      cd12063
      Location:284345
      SH3_Caskin2; Src Homology 3 domain of CASK interacting protein 2
      cd00204
      Location:76209
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:152251
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:761
      Ank_4; Ankyrin repeats (many copies)
      pfam16632
      Location:11441201
      Caskin-tail; C-terminal region of Caskin
      pfam16907
      Location:797881
      Caskin-Pro-rich; Proline rich region of Caskin proteins
      sd00045
      Location:114145
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      115798987..115813592 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011248719.2XP_011247021.1  caskin-2 isoform X3

      Conserved Domains (9) summary
      cd09497
      Location:355420
      SAM_caskin1,2_repeat1; SAM domain of caskin protein repeat 1
      cd09498
      Location:421491
      SAM_caskin1,2_repeat2; SAM domain of caskin protein repeat 2
      smart00454
      Location:429488
      SAM; Sterile alpha motif
      cd12063
      Location:152213
      SH3_Caskin2; Src Homology 3 domain of CASK interacting protein 2
      cd00204
      Location:12128
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:20119
      Ank_2; Ankyrin repeats (3 copies)
      pfam16632
      Location:10121069
      Caskin-tail; C-terminal region of Caskin
      pfam16907
      Location:665749
      Caskin-Pro-rich; Proline rich region of Caskin proteins
      sd00045
      Location:1854
      ANK; ANK repeat [structural motif]
    2. XM_011248718.2XP_011247020.1  caskin-2 isoform X2

      Conserved Domains (9) summary
      cd09497
      Location:405470
      SAM_caskin1,2_repeat1; SAM domain of caskin protein repeat 1
      cd09498
      Location:471541
      SAM_caskin1,2_repeat2; SAM domain of caskin protein repeat 2
      smart00454
      Location:479538
      SAM; Sterile alpha motif
      cd12063
      Location:202263
      SH3_Caskin2; Src Homology 3 domain of CASK interacting protein 2
      cd00204
      Location:27159
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:70169
      Ank_2; Ankyrin repeats (3 copies)
      pfam16632
      Location:10621119
      Caskin-tail; C-terminal region of Caskin
      pfam16907
      Location:715799
      Caskin-Pro-rich; Proline rich region of Caskin proteins
      sd00045
      Location:3263
      ANK; ANK repeat [structural motif]
    3. XM_006532181.3XP_006532244.1  caskin-2 isoform X1

      Conserved Domains (9) summary
      cd09497
      Location:466531
      SAM_caskin1,2_repeat1; SAM domain of caskin protein repeat 1
      cd09498
      Location:532602
      SAM_caskin1,2_repeat2; SAM domain of caskin protein repeat 2
      smart00454
      Location:540599
      SAM; Sterile alpha motif
      cd12063
      Location:263324
      SH3_Caskin2; Src Homology 3 domain of CASK interacting protein 2
      cd00204
      Location:55188
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:131230
      Ank_2; Ankyrin repeats (3 copies)
      pfam16632
      Location:11231180
      Caskin-tail; C-terminal region of Caskin
      pfam16907
      Location:776860
      Caskin-Pro-rich; Proline rich region of Caskin proteins
      sd00045
      Location:93124
      ANK; ANK repeat [structural motif]
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