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    ABHD16B abhydrolase domain containing 16B [ Homo sapiens (human) ]

    Gene ID: 140701, updated on 18-Sep-2024

    Summary

    Official Symbol
    ABHD16Bprovided by HGNC
    Official Full Name
    abhydrolase domain containing 16Bprovided by HGNC
    Primary source
    HGNC:HGNC:16128
    See related
    Ensembl:ENSG00000183260 MIM:620190; AllianceGenome:HGNC:16128
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C20orf135; dJ591C20.1
    Summary
    Predicted to enable acylglycerol lipase activity; palmitoyl-(protein) hydrolase activity; and phospholipase activity. Predicted to be involved in monoacylglycerol catabolic process and phosphatidylserine catabolic process. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    NEW
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    Genomic context

    See ABHD16B in Genome Data Viewer
    Location:
    20q13.33
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (63861498..63862988)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (65681341..65682831)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (62492851..62494341)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene zinc finger and BTB domain containing 46 Neighboring gene ZBTB46 antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:62446368-62447118 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:62447119-62447869 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:62460361-62461052 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13187 Neighboring gene Sharpr-MPRA regulatory region 10064 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:62475261-62475938 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:62477766-62477915 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18252 Neighboring gene chromosome 20 putative open reading frame 181 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18253 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:62484853-62485706 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13188 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13189 Neighboring gene uncharacterized LOC112268269 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18254 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr20:62495674-62496873 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:62497355-62498074 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_61287 Neighboring gene TPD52 like 2 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_61295 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_61302 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:62517585-62517755 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:62525794-62526321 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13191 Neighboring gene DnaJ heat shock protein family (Hsp40) member C5 Neighboring gene RNA, U1 small nuclear 134, pseudogene

    Genomic regions, transcripts, and products

    Phenotypes

    EBI GWAS Catalog

    Description
    Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
    EBI GWAS Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of abhydrolase domain containing 16B (ABHD16B) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Clone Names

    • MGC42974

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables monoacylglycerol lipase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phospholipase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in monoacylglycerol catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in phosphatidylserine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    protein ABHD16B
    Names
    abhydrolase domain-containing protein 16B
    alpha/beta hydrolase domain-containing protein 16B

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_080622.4NP_542189.1  protein ABHD16B

      See identical proteins and their annotated locations for NP_542189.1

      Status: VALIDATED

      Source sequence(s)
      AL118506
      Consensus CDS
      CCDS13539.1
      UniProtKB/Swiss-Prot
      Q9H3Z7
      Related
      ENSP00000358932.3, ENST00000369916.5
      Conserved Domains (1) summary
      pfam12695
      Location:194284
      Abhydrolase_5; Alpha/beta hydrolase family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      63861498..63862988
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      65681341..65682831
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)