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    F2 coagulation factor II [ Mus musculus (house mouse) ]

    Gene ID: 14061, updated on 12-May-2024

    Summary

    Official Symbol
    F2provided by MGI
    Official Full Name
    coagulation factor IIprovided by MGI
    Primary source
    MGI:MGI:88380
    See related
    Ensembl:ENSMUSG00000027249 AllianceGenome:MGI:88380
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cf2; FII; Cf-2
    Summary
    This gene encodes a vitamin K-dependent glycoprotein coagulation factor that plays an important role in the process of blood coagulation and hemostasis. The encoded protein is an inactive zymogen that undergoes enzymatic cleavage by the coagulation factor Xa to form an active serine protease that converts soluble fibrinogen to insoluble fibrin clot. Most of the mice lacking the encoded protein die at an embryonic stage due to defects in yolk sac vasculature, while the rare nenonates succumb to hemorrhage on the first postnatal day. [provided by RefSeq, Apr 2015]
    Expression
    Biased expression in liver adult (RPKM 695.9), liver E18 (RPKM 621.7) and 3 other tissues See more
    Orthologs
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    Genomic context

    Location:
    2 E1; 2 50.63 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (91442742..91466799, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (91612397..91636457, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5945 Neighboring gene predicted gene 13770 Neighboring gene cytoskeleton associated protein 5 Neighboring gene small nucleolar RNA, C/D box 67 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:91475064-91475265 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:91486007-91486292 Neighboring gene STARR-positive B cell enhancer ABC_E1007 Neighboring gene cytochrome c oxidase subunit 7B, mitochondrial pseudogene Neighboring gene zinc finger protein 408

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (6)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables endopeptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables heparin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables lipopolysaccharide binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables peptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables serine-type endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables serine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables serine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables thrombospondin receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in G protein-coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within acute-phase response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within blood coagulation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in blood coagulation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell surface receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cytolysis by host of symbiont cells ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in fibrinolysis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within hemostasis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ligand-gated ion channel signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in ligand-gated ion channel signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of astrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cytokine production involved in inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neutrophil-mediated killing of gram-negative bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in platelet activation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within platelet activation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in platelet activation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of blood coagulation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of blood coagulation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of cell growth IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of cell population proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of collagen biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of insulin secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of insulin secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of lipid kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein localization to nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of reactive oxygen species metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of release of sequestered calcium ion into cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within regulation of cell shape IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to wounding ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within thrombin-activated receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in collagen-containing extracellular matrix HDA PubMed 
    is_active_in collagen-containing extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in collagen-containing extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    prothrombin
    Names
    thrombin
    NP_034298.1
    XP_011237590.1
    XP_030103259.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010168.4NP_034298.1  prothrombin preproprotein

      See identical proteins and their annotated locations for NP_034298.1

      Status: REVIEWED

      Source sequence(s)
      AL691489
      Consensus CDS
      CCDS16434.1
      UniProtKB/Swiss-Prot
      P19221
      UniProtKB/TrEMBL
      H7BX99, Q3TJ94
      Related
      ENSMUSP00000028681.9, ENSMUST00000028681.15
      Conserved Domains (5) summary
      smart00020
      Location:360610
      Tryp_SPc; Trypsin-like serine protease
      smart00069
      Location:2589
      GLA; Domain containing Gla (gamma-carboxyglutamate) residues
      smart00130
      Location:107189
      KR; Kringle domain
      cd00190
      Location:361613
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam09396
      Location:313360
      Thrombin_light; Thrombin light chain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      91442742..91466799 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030247399.1XP_030103259.1  prothrombin isoform X1

      UniProtKB/TrEMBL
      H7BX99
      Conserved Domains (4) summary
      smart00020
      Location:360575
      Tryp_SPc; Trypsin-like serine protease
      smart00069
      Location:2589
      GLA; Domain containing Gla (gamma-carboxyglutamate) residues
      smart00130
      Location:107189
      KR; Kringle domain
      pfam09396
      Location:314360
      Thrombin_light; Thrombin light chain
    2. XM_011239288.2XP_011237590.1  prothrombin isoform X1

      UniProtKB/TrEMBL
      H7BX99
      Conserved Domains (4) summary
      smart00020
      Location:360575
      Tryp_SPc; Trypsin-like serine protease
      smart00069
      Location:2589
      GLA; Domain containing Gla (gamma-carboxyglutamate) residues
      smart00130
      Location:107189
      KR; Kringle domain
      pfam09396
      Location:314360
      Thrombin_light; Thrombin light chain