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    Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit [ Mus musculus (house mouse) ]

    Gene ID: 14056, updated on 6-Sep-2021

    Summary

    Official Symbol
    Ezh2provided by MGI
    Official Full Name
    enhancer of zeste 2 polycomb repressive complex 2 subunitprovided by MGI
    Primary source
    MGI:MGI:107940
    See related
    Ensembl:ENSMUSG00000029687
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Enx-; Enx1; KMT6; Enx-1; Enx1h; mKIAA4065
    Expression
    Biased expression in CNS E11.5 (RPKM 46.4), CNS E14 (RPKM 30.5) and 11 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Ezh2 in Genome Data Viewer
    Location:
    6 B2.3; 6 22.92 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (47507208..47572309, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (47530274..47595270, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (47480273..47545029, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene TAR (HIV) RNA binding protein 2 pseudogene Neighboring gene cullin 1 Neighboring gene RIKEN cDNA F830010H11 gene Neighboring gene predicted gene, 40371 Neighboring gene predicted gene, 40369 Neighboring gene 4.5S RNA

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA4065, MGC90723

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA polymerase II core promoter sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA polymerase II core promoter sequence-specific DNA binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables chromatin DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables chromatin DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables histone methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone methyltransferase activity (H3-K27 specific) ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone-lysine N-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables primary miRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables promoter-specific chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-lysine N-methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ribonucleoprotein complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transcription cis-regulatory region binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription corepressor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transcription corepressor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in B cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within DNA methylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within G1 to G0 transition IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cardiac muscle hypertrophy in response to stress IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to hydrogen peroxide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to trichostatin A IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cerebellar cortex development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within chromatin organization IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within hepatocyte homeostasis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within histone H3-K27 methylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in histone H3-K27 methylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in histone H3-K27 methylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within histone H3-K27 trimethylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within histone H3-K27 trimethylation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within histone methylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in histone methylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in immunoglobulin heavy chain V-D-J recombination TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within liver regeneration IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within methylation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within negative regulation of DNA-binding transcription factor activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of G1/S transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cytokine production involved in inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of epidermal cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of gene expression, epigenetic ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of retinoic acid receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of striated muscle cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of transcription elongation from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of MAP kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell cycle G1/S phase transition ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of dendrite development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of epithelial to mesenchymal transition ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein localization to chromatin IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of circadian rhythm IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of circadian rhythm ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of gliogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of neurogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to tetrachloromethane IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within rhythmic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in subtelomeric heterochromatin assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in synaptic transmission, GABAergic ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of ESC/E(Z) complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of ESC/E(Z) complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    part_of chromatin silencing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in pericentric heterochromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in pronucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    histone-lysine N-methyltransferase EZH2
    Names
    enhancer of zeste homolog 2
    NP_001140161.1
    NP_031997.2
    XP_006505583.1
    XP_006505584.1
    XP_006505586.1
    XP_006505587.1
    XP_006505588.1
    XP_006505589.1
    XP_006505590.1
    XP_006505592.1
    XP_030111010.1
    XP_030111011.1
    XP_030111012.1
    XP_030111015.1
    XP_036021710.1
    XP_036021711.1
    XP_036021712.1
    XP_036021713.1
    XP_036021714.1
    XP_036021715.1
    XP_036021716.1
    XP_036021718.1
    XP_036021719.1
    XP_036021720.1
    XP_036021721.1
    XP_036021722.1
    XP_036021724.1
    XP_036021725.1
    XP_036021726.1
    XP_036021727.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001146689.1NP_001140161.1  histone-lysine N-methyltransferase EZH2 isoform 2

      See identical proteins and their annotated locations for NP_001140161.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This difference results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AK157853, AK220174, BC079538
      Consensus CDS
      CCDS51760.1
      UniProtKB/TrEMBL
      Q3TZH6, Q571L5, Q6AXH7
      Related
      ENSMUSP00000110265.2, ENSMUST00000114618.8
      Conserved Domains (4) summary
      cd19218
      Location:605724
      SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
      pfam11616
      Location:3968
      EZH2_WD-Binding; WD repeat binding protein EZH2
      pfam18118
      Location:149240
      PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
      pfam18264
      Location:555586
      preSET_CXC; CXC domain
    2. NM_007971.2NP_031997.2  histone-lysine N-methyltransferase EZH2 isoform 1

      See identical proteins and their annotated locations for NP_031997.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). This isoform is also known as ENX-1A.
      Source sequence(s)
      AK157853, AK220174, BC079538
      Consensus CDS
      CCDS20096.1
      UniProtKB/Swiss-Prot
      Q61188
      UniProtKB/TrEMBL
      Q3TZH6, Q571L5, Q6AXH7
      Related
      ENSMUSP00000080419.7, ENSMUST00000081721.13
      Conserved Domains (4) summary
      cd19218
      Location:609728
      SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
      pfam11616
      Location:3968
      EZH2_WD-Binding; WD repeat binding protein EZH2
      pfam18118
      Location:158249
      PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
      pfam18264
      Location:559590
      preSET_CXC; CXC domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      47507208..47572309 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036165821.1XP_036021714.1  histone-lysine N-methyltransferase EZH2 isoform X2

      Conserved Domains (4) summary
      cd19218
      Location:609728
      SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
      pfam11616
      Location:3968
      EZH2_WD-Binding; WD repeat binding protein EZH2
      pfam18118
      Location:158249
      PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
      pfam18264
      Location:559590
      preSET_CXC; CXC domain
    2. XM_006505521.4XP_006505584.1  histone-lysine N-methyltransferase EZH2 isoform X1

      See identical proteins and their annotated locations for XP_006505584.1

      Conserved Domains (4) summary
      cd19218
      Location:614733
      SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
      pfam11616
      Location:3968
      EZH2_WD-Binding; WD repeat binding protein EZH2
      pfam18118
      Location:158249
      PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
      pfam18264
      Location:564595
      preSET_CXC; CXC domain
    3. XM_036165825.1XP_036021718.1  histone-lysine N-methyltransferase EZH2 isoform X4

      Conserved Domains (4) summary
      cd19218
      Location:600719
      SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
      pfam11616
      Location:3968
      EZH2_WD-Binding; WD repeat binding protein EZH2
      pfam18118
      Location:149240
      PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
      pfam18264
      Location:550581
      preSET_CXC; CXC domain
    4. XM_030255152.1XP_030111012.1  histone-lysine N-methyltransferase EZH2 isoform X6

      Conserved Domains (4) summary
      pfam11616
      Location:3967
      EZH2_WD-Binding; WD repeat binding protein EZH2
      pfam18118
      Location:158249
      PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
      pfam18264
      Location:517548
      preSET_CXC; CXC domain
      cd19218
      Location:567686
      SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
    5. XM_036165829.1XP_036021722.1  histone-lysine N-methyltransferase EZH2 isoform X10

      Conserved Domains (3) summary
      cd19218
      Location:500619
      SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
      pfam18118
      Location:49140
      PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
      pfam18264
      Location:450481
      preSET_CXC; CXC domain
    6. XM_006505526.5XP_006505589.1  histone-lysine N-methyltransferase EZH2 isoform X1

      See identical proteins and their annotated locations for XP_006505589.1

      Conserved Domains (4) summary
      cd19218
      Location:614733
      SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
      pfam11616
      Location:3968
      EZH2_WD-Binding; WD repeat binding protein EZH2
      pfam18118
      Location:158249
      PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
      pfam18264
      Location:564595
      preSET_CXC; CXC domain
    7. XM_006505525.2XP_006505588.1  histone-lysine N-methyltransferase EZH2 isoform X8

      Conserved Domains (4) summary
      cd19218
      Location:558677
      SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
      pfam11616
      Location:3968
      EZH2_WD-Binding; WD repeat binding protein EZH2
      pfam18118
      Location:149240
      PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
      pfam18264
      Location:508539
      preSET_CXC; CXC domain
    8. XM_006505523.2XP_006505586.1  histone-lysine N-methyltransferase EZH2 isoform X4

      Conserved Domains (4) summary
      cd19218
      Location:600719
      SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
      pfam11616
      Location:3968
      EZH2_WD-Binding; WD repeat binding protein EZH2
      pfam18118
      Location:149240
      PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
      pfam18264
      Location:550581
      preSET_CXC; CXC domain
    9. XM_036165826.1XP_036021719.1  histone-lysine N-methyltransferase EZH2 isoform X7

      Conserved Domains (4) summary
      cd19218
      Location:563682
      SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
      pfam11616
      Location:3968
      EZH2_WD-Binding; WD repeat binding protein EZH2
      pfam18118
      Location:149240
      PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
      pfam18264
      Location:513544
      preSET_CXC; CXC domain
    10. XM_006505524.3XP_006505587.1  histone-lysine N-methyltransferase EZH2 isoform X5

      Conserved Domains (4) summary
      pfam11616
      Location:3967
      EZH2_WD-Binding; WD repeat binding protein EZH2
      pfam18118
      Location:158249
      PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
      pfam18264
      Location:522553
      preSET_CXC; CXC domain
      cd19218
      Location:572691
      SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
    11. XM_006505529.3XP_006505592.1  histone-lysine N-methyltransferase EZH2 isoform X12

      Conserved Domains (2) summary
      cd19218
      Location:372491
      SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
      pfam18264
      Location:322353
      preSET_CXC; CXC domain
    12. XM_036165828.1XP_036021721.1  histone-lysine N-methyltransferase EZH2 isoform X9

      Conserved Domains (3) summary
      cd19218
      Location:505624
      SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
      pfam18118
      Location:49140
      PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
      pfam18264
      Location:455486
      preSET_CXC; CXC domain
    13. XM_036165833.1XP_036021726.1  histone-lysine N-methyltransferase EZH2 isoform X12

      Conserved Domains (2) summary
      cd19218
      Location:372491
      SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
      pfam18264
      Location:322353
      preSET_CXC; CXC domain
    14. XM_036165832.1XP_036021725.1  histone-lysine N-methyltransferase EZH2 isoform X11

      Conserved Domains (2) summary
      cd19218
      Location:377496
      SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
      pfam18264
      Location:327358
      preSET_CXC; CXC domain
    15. XM_036165834.1XP_036021727.1  histone-lysine N-methyltransferase EZH2 isoform X14

      Conserved Domains (2) summary
      cd19218
      Location:330449
      SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
      pfam18264
      Location:280311
      preSET_CXC; CXC domain
    16. XM_030255155.1XP_030111015.1  histone-lysine N-methyltransferase EZH2 isoform X13

      Conserved Domains (2) summary
      pfam18264
      Location:285316
      preSET_CXC; CXC domain
      cd19218
      Location:335454
      SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
    17. XM_006505527.2XP_006505590.1  histone-lysine N-methyltransferase EZH2 isoform X11

      See identical proteins and their annotated locations for XP_006505590.1

      Conserved Domains (2) summary
      cd19218
      Location:377496
      SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
      pfam18264
      Location:327358
      preSET_CXC; CXC domain
    18. XM_030255151.2XP_030111011.1  histone-lysine N-methyltransferase EZH2 isoform X6

      Related
      ENSMUSP00000090318.7, ENSMUST00000092648.13
      Conserved Domains (4) summary
      pfam11616
      Location:3967
      EZH2_WD-Binding; WD repeat binding protein EZH2
      pfam18118
      Location:158249
      PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
      pfam18264
      Location:517548
      preSET_CXC; CXC domain
      cd19218
      Location:567686
      SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
    19. XM_030255150.2XP_030111010.1  histone-lysine N-methyltransferase EZH2 isoform X2

      Conserved Domains (4) summary
      cd19218
      Location:609728
      SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
      pfam11616
      Location:3968
      EZH2_WD-Binding; WD repeat binding protein EZH2
      pfam18118
      Location:158249
      PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
      pfam18264
      Location:559590
      preSET_CXC; CXC domain
    20. XM_006505520.5XP_006505583.1  histone-lysine N-methyltransferase EZH2 isoform X1

      See identical proteins and their annotated locations for XP_006505583.1

      Conserved Domains (4) summary
      cd19218
      Location:614733
      SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
      pfam11616
      Location:3968
      EZH2_WD-Binding; WD repeat binding protein EZH2
      pfam18118
      Location:158249
      PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
      pfam18264
      Location:564595
      preSET_CXC; CXC domain
    21. XM_036165827.1XP_036021720.1  histone-lysine N-methyltransferase EZH2 isoform X8

      Conserved Domains (4) summary
      cd19218
      Location:558677
      SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
      pfam11616
      Location:3968
      EZH2_WD-Binding; WD repeat binding protein EZH2
      pfam18118
      Location:149240
      PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
      pfam18264
      Location:508539
      preSET_CXC; CXC domain
    22. XM_036165823.1XP_036021716.1  histone-lysine N-methyltransferase EZH2 isoform X3

      Conserved Domains (4) summary
      cd19218
      Location:605724
      SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
      pfam11616
      Location:3968
      EZH2_WD-Binding; WD repeat binding protein EZH2
      pfam18118
      Location:149240
      PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
      pfam18264
      Location:555586
      preSET_CXC; CXC domain
    23. XM_036165831.1XP_036021724.1  histone-lysine N-methyltransferase EZH2 isoform X11

      Conserved Domains (2) summary
      cd19218
      Location:377496
      SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
      pfam18264
      Location:327358
      preSET_CXC; CXC domain
    24. XM_036165817.1XP_036021710.1  histone-lysine N-methyltransferase EZH2 isoform X1

      Conserved Domains (4) summary
      cd19218
      Location:614733
      SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
      pfam11616
      Location:3968
      EZH2_WD-Binding; WD repeat binding protein EZH2
      pfam18118
      Location:158249
      PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
      pfam18264
      Location:564595
      preSET_CXC; CXC domain
    25. XM_036165820.1XP_036021713.1  histone-lysine N-methyltransferase EZH2 isoform X2

      Conserved Domains (4) summary
      cd19218
      Location:609728
      SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
      pfam11616
      Location:3968
      EZH2_WD-Binding; WD repeat binding protein EZH2
      pfam18118
      Location:158249
      PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
      pfam18264
      Location:559590
      preSET_CXC; CXC domain
    26. XM_036165818.1XP_036021711.1  histone-lysine N-methyltransferase EZH2 isoform X1

      Conserved Domains (4) summary
      cd19218
      Location:614733
      SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
      pfam11616
      Location:3968
      EZH2_WD-Binding; WD repeat binding protein EZH2
      pfam18118
      Location:158249
      PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
      pfam18264
      Location:564595
      preSET_CXC; CXC domain
    27. XM_036165822.1XP_036021715.1  histone-lysine N-methyltransferase EZH2 isoform X2

      Conserved Domains (4) summary
      cd19218
      Location:609728
      SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
      pfam11616
      Location:3968
      EZH2_WD-Binding; WD repeat binding protein EZH2
      pfam18118
      Location:158249
      PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
      pfam18264
      Location:559590
      preSET_CXC; CXC domain
    28. XM_036165819.1XP_036021712.1  histone-lysine N-methyltransferase EZH2 isoform X1

      Conserved Domains (4) summary
      cd19218
      Location:614733
      SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
      pfam11616
      Location:3968
      EZH2_WD-Binding; WD repeat binding protein EZH2
      pfam18118
      Location:158249
      PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
      pfam18264
      Location:564595
      preSET_CXC; CXC domain
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