Format

Send to:

Choose Destination
    • Showing Current items.

    Ezh1 enhancer of zeste 1 polycomb repressive complex 2 subunit [ Mus musculus (house mouse) ]

    Gene ID: 14055, updated on 2-Oct-2018

    Summary

    Official Symbol
    Ezh1provided by MGI
    Official Full Name
    enhancer of zeste 1 polycomb repressive complex 2 subunitprovided by MGI
    Primary source
    MGI:MGI:1097695
    See related
    Ensembl:ENSMUSG00000006920 Vega:OTTMUSG00000002729
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ENX-2
    Summary
    This gene encodes a member of the Polycomb-group (PcG) family. The encoded protein is interchangeable with the related Enhancer of zeste 2 (Ezh2) protein as a core component of the polycomb repressive complex 2 (PRC2), which methylates histone H3 at lysine 27 and results in the transcriptional repression of affected target genes. This complex is involved in carrying out cell-fate decisions during embryonic stem cell differentiation. [provided by RefSeq, Sep 2014]
    Expression
    Ubiquitous expression in lung adult (RPKM 16.7), kidney adult (RPKM 16.3) and 28 other tissues See more
    Orthologs

    Genomic context

    See Ezh1 in Genome Data Viewer
    Location:
    11 D; 11 64.37 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (101191115..101226463, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (101052429..101087764, complement)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene pleckstrin homology domain containing, family H (with MyTH4 domain) member 3 Neighboring gene contactin associated protein-like 1 Neighboring gene chemokine (C-C motif) receptor 10 Neighboring gene receptor (calcitonin) activity modifying protein 2 Neighboring gene vacuolar protein sorting 25

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    histone methyltransferase activity (H3-K27 specific) IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histone-lysine N-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    chromatin organization IEA
    Inferred from Electronic Annotation
    more info
     
    hepatocyte homeostasis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    histone H3-K27 methylation IEA
    Inferred from Electronic Annotation
    more info
     
    histone H3-K27 trimethylation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    liver regeneration IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    methylation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    response to tetrachloromethane IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    ESC/E(Z) complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ESC/E(Z) complex ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    histone-lysine N-methyltransferase EZH1
    Names
    enhancer of zeste homolog 1
    NP_031996.1
    XP_006532241.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007970.3NP_031996.1  histone-lysine N-methyltransferase EZH1

      See identical proteins and their annotated locations for NP_031996.1

      Status: REVIEWED

      Source sequence(s)
      AK140694, AL590969, BQ033903
      Consensus CDS
      CCDS36335.1
      UniProtKB/Swiss-Prot
      P70351
      UniProtKB/TrEMBL
      A0A0R4J1C0
      Related
      ENSMUSP00000102906.1, ENSMUST00000107285.7
      Conserved Domains (5) summary
      smart00717
      Location:436477
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      smart00317
      Location:616737
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      COG2940
      Location:466730
      SET; SET domain-containing protein (function unknown) [General function prediction only]
      cd00167
      Location:436477
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam11616
      Location:4270
      EZH2_WD-Binding; WD repeat binding protein EZH2

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      101191115..101226463 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006532178.3XP_006532241.1  histone-lysine N-methyltransferase EZH1 isoform X1

      See identical proteins and their annotated locations for XP_006532241.1

      UniProtKB/Swiss-Prot
      P70351
      Related
      ENSMUSP00000102905.1, OTTMUSP00000002578, ENSMUST00000107284.7, OTTMUST00000005416
      Conserved Domains (5) summary
      smart00717
      Location:433474
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      smart00317
      Location:613734
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      COG2940
      Location:463727
      SET; SET domain-containing protein (function unknown) [General function prediction only]
      cd00167
      Location:433474
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam11616
      Location:3967
      EZH2_WD-Binding; WD repeat binding protein EZH2
    Support Center