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    Ezh1 enhancer of zeste 1 polycomb repressive complex 2 subunit [ Mus musculus (house mouse) ]

    Gene ID: 14055, updated on 26-Sep-2022

    Summary

    Official Symbol
    Ezh1provided by MGI
    Official Full Name
    enhancer of zeste 1 polycomb repressive complex 2 subunitprovided by MGI
    Primary source
    MGI:MGI:1097695
    See related
    Ensembl:ENSMUSG00000006920 AllianceGenome:MGI:1097695
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ENX-2
    Summary
    This gene encodes a member of the Polycomb-group (PcG) family. The encoded protein is interchangeable with the related Enhancer of zeste 2 (Ezh2) protein as a core component of the polycomb repressive complex 2 (PRC2), which methylates histone H3 at lysine 27 and results in the transcriptional repression of affected target genes. This complex is involved in carrying out cell-fate decisions during embryonic stem cell differentiation. [provided by RefSeq, Sep 2014]
    Expression
    Ubiquitous expression in lung adult (RPKM 16.7), kidney adult (RPKM 16.3) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Ezh1 in Genome Data Viewer
    Location:
    11 D; 11 64.37 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (101081941..101117289, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (101191115..101226463, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene pleckstrin homology domain containing, family H (with MyTH4 domain) member 3 Neighboring gene contactin associated protein-like 1 Neighboring gene chemokine (C-C motif) receptor 10 Neighboring gene receptor (calcitonin) activity modifying protein 2 Neighboring gene vacuolar protein sorting 25

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Endonuclease-mediated (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    NOT enables DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone H3K27 methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables histone H3K27 methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to histone binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables histone lysine N-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription corepressor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within chromatin organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chromatin remodeling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in facultative heterochromatin formation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within hepatocyte homeostasis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in heterochromatin formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in heterochromatin formation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in histone H3-K27 methylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in histone H3-K27 trimethylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within histone H3-K27 trimethylation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within histone methylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within liver regeneration IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within methylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to tetrachloromethane IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in subtelomeric heterochromatin formation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of ESC/E(Z) complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of ESC/E(Z) complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of ESC/E(Z) complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromosome, telomeric region IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    located_in heterochromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    histone-lysine N-methyltransferase EZH1
    Names
    enhancer of zeste homolog 1
    NP_031996.1
    XP_006532241.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001403807.1NP_001390736.1  histone-lysine N-methyltransferase EZH1 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AL590969
    2. NM_001403809.1NP_001390738.1  histone-lysine N-methyltransferase EZH1 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AL590969
      UniProtKB/Swiss-Prot
      Q9R089
    3. NM_001403810.1NP_001390739.1  histone-lysine N-methyltransferase EZH1 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AL590969
    4. NM_001403811.1NP_001390740.1  histone-lysine N-methyltransferase EZH1 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AL590969
    5. NM_001403812.1NP_001390741.1  histone-lysine N-methyltransferase EZH1 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AL590969
    6. NM_001403813.1NP_001390742.1  histone-lysine N-methyltransferase EZH1 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AL590969
    7. NM_001403814.1NP_001390743.1  histone-lysine N-methyltransferase EZH1 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AL590969
    8. NM_001403815.1NP_001390744.1  histone-lysine N-methyltransferase EZH1 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AL590969
    9. NM_001403816.1NP_001390745.1  histone-lysine N-methyltransferase EZH1 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AL590969
    10. NM_001403818.1NP_001390747.1  histone-lysine N-methyltransferase EZH1 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AL590969
    11. NM_001403821.1NP_001390750.1  histone-lysine N-methyltransferase EZH1 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL590969
      UniProtKB/TrEMBL
      A0A0R4J1C0, A0A8C6GKZ9
    12. NM_001403822.1NP_001390751.1  histone-lysine N-methyltransferase EZH1 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AL590969
    13. NM_007970.4NP_031996.1  histone-lysine N-methyltransferase EZH1 isoform 1

      See identical proteins and their annotated locations for NP_031996.1

      Status: REVIEWED

      Source sequence(s)
      AL590969
      Consensus CDS
      CCDS36335.1
      UniProtKB/Swiss-Prot
      P70351
      UniProtKB/TrEMBL
      A0A0R4J1C0, A0A8C6GKZ9
      Related
      ENSMUSP00000102906.2, ENSMUST00000107285.8
      Conserved Domains (5) summary
      smart00717
      Location:436477
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      smart00317
      Location:616737
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      COG2940
      Location:466730
      SET; SET domain-containing protein (function unknown) [General function prediction only]
      cd00167
      Location:436477
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam11616
      Location:4270
      EZH2_WD-Binding; WD repeat binding protein EZH2

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      101081941..101117289 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006532178.5XP_006532241.1  histone-lysine N-methyltransferase EZH1 isoform X1

      UniProtKB/Swiss-Prot
      P70351
      Related
      ENSMUSP00000102905.2, ENSMUST00000107284.8
      Conserved Domains (5) summary
      COG2940
      Location:463727
      SET; SET domain-containing protein (function unknown) [General function prediction only]
      cd00167
      Location:433474
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam11616
      Location:3967
      EZH2_WD-Binding; WD repeat binding protein EZH2
      pfam18118
      Location:159262
      PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
      cd19217
      Location:608743
      SET_EZH1; SET domain found in enhancer of zeste homolog 1 (EZH1) and similar proteins