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    Eri3 exoribonuclease 3 [ Mus musculus (house mouse) ]

    Gene ID: 140546, updated on 23-Jun-2021

    Summary

    Official Symbol
    Eri3provided by MGI
    Official Full Name
    exoribonuclease 3provided by MGI
    Primary source
    MGI:MGI:2153887
    See related
    Ensembl:ENSMUSG00000033423
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    P; PI; PINT1; Prnpip1
    Expression
    Ubiquitous expression in CNS E18 (RPKM 32.0), ovary adult (RPKM 28.1) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Eri3 in Genome Data Viewer
    Location:
    4; 4 D1
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (117407416..117531494)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (117550241..117674297)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (117223099..117346886)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene ring finger protein 220 Neighboring gene predicted gene 12827 Neighboring gene predicted gene, 34669 Neighboring gene zinc finger (CCCH type), RNA binding motif and serine/arginine rich 2 pseudogene Neighboring gene DNA methyltransferase 1-associated protein 1 Neighboring gene predicted gene, 34746

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3'-5'-exoribonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    ERI1 exoribonuclease 3
    Names
    prion interactor 1
    prion protein interacting protein 1
    prion protein-interacting protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001285899.1NP_001272828.1  ERI1 exoribonuclease 3 isoform b

      See identical proteins and their annotated locations for NP_001272828.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in its 5' UTR, initiates translation at an alternate start codon, and uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is shorter than isoform a.
      Source sequence(s)
      BC117540, BE944838, BY255598
      UniProtKB/Swiss-Prot
      Q8C460
      Conserved Domains (1) summary
      cd06133
      Location:105282
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
    2. NM_001285901.1NP_001272830.1  ERI1 exoribonuclease 3 isoform c

      See identical proteins and their annotated locations for NP_001272830.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a. Variants 3 and 5 encode the same isoform (c).
      Source sequence(s)
      AK083017, BE944838, BY110468, BY258104
      UniProtKB/Swiss-Prot
      Q8C460
      Conserved Domains (1) summary
      cd06133
      Location:68245
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
    3. NM_001285902.1NP_001272831.1  ERI1 exoribonuclease 3 isoform d

      See identical proteins and their annotated locations for NP_001272831.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (d) is shorter at the N-terminus, compared to isoform a.
      Source sequence(s)
      AA259566, AK083017, BE944838, BY110468
      UniProtKB/Swiss-Prot
      Q8C460
      Conserved Domains (1) summary
      cd06133
      Location:1146
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
    4. NM_001356404.1NP_001343333.1  ERI1 exoribonuclease 3 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a. Variants 3 and 5 encode the same isoform (c).
      Source sequence(s)
      AK083017, BE944838, BY110468, BY288119
      Conserved Domains (1) summary
      cd06133
      Location:68245
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
    5. NM_001356405.1NP_001343334.1  ERI1 exoribonuclease 3 isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (e) has the same N- and C-termini, but is 2 aa shorter than isoform a.
      Source sequence(s)
      AK083017, BE944838, BY255598
      Conserved Domains (1) summary
      cd06133
      Location:144321
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
    6. NM_001379279.1NP_001366208.1  ERI1 exoribonuclease 3 isoform f

      Status: VALIDATED

      Source sequence(s)
      AL645740, AL671520
      Conserved Domains (1) summary
      cd06133
      Location:146345
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
    7. NM_001379280.1NP_001366209.1  ERI1 exoribonuclease 3 isoform g

      Status: VALIDATED

      Source sequence(s)
      AL645740, AL671520
      Conserved Domains (1) summary
      cd06133
      Location:107284
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
    8. NM_001379281.1NP_001366210.1  ERI1 exoribonuclease 3 isoform h

      Status: VALIDATED

      Source sequence(s)
      AL645740, AL671520
      Conserved Domains (1) summary
      cd06133
      Location:68267
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
    9. NM_001379282.1NP_001366211.1  ERI1 exoribonuclease 3 isoform c

      Status: VALIDATED

      Source sequence(s)
      AL645740, AL671520
      Conserved Domains (1) summary
      cd06133
      Location:68245
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
    10. NM_001379283.1NP_001366212.1  ERI1 exoribonuclease 3 isoform c

      Status: VALIDATED

      Source sequence(s)
      AL645740, AL671520
      Conserved Domains (1) summary
      cd06133
      Location:68245
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
    11. NM_001379284.1NP_001366213.1  ERI1 exoribonuclease 3 isoform d

      Status: VALIDATED

      Source sequence(s)
      AL645740, AL671520
      Conserved Domains (1) summary
      cd06133
      Location:1146
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
    12. NM_001379285.1NP_001366214.1  ERI1 exoribonuclease 3 isoform i

      Status: VALIDATED

      Source sequence(s)
      AL645740, AL671520
      Conserved Domains (1) summary
      cd06133
      Location:35205
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
    13. NM_080469.4NP_536717.2  ERI1 exoribonuclease 3 isoform a

      See identical proteins and their annotated locations for NP_536717.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AK083017, BE944838, BY255598
      Consensus CDS
      CCDS18535.1
      UniProtKB/Swiss-Prot
      Q8C460
      Related
      ENSMUSP00000042796.9, ENSMUST00000037127.15
      Conserved Domains (1) summary
      cd06133
      Location:146323
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      117407416..117531494
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017319962.3XP_017175451.2  ERI1 exoribonuclease 3 isoform X5

      Conserved Domains (1) summary
      cd06133
      Location:121285
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
    2. XM_030253198.2XP_030109058.2  ERI1 exoribonuclease 3 isoform X8

      Conserved Domains (1) summary
      cd06133
      Location:121298
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
    3. XM_036163665.1XP_036019558.1  ERI1 exoribonuclease 3 isoform X10

      Conserved Domains (1) summary
      cd06133
      Location:121256
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
    4. XM_030253202.1XP_030109062.1  ERI1 exoribonuclease 3 isoform X12

      Conserved Domains (1) summary
      cd06133
      Location:68245
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
    5. XM_017319971.2XP_017175460.1  ERI1 exoribonuclease 3 isoform X13

      Conserved Domains (1) summary
      cd06133
      Location:1133
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
    6. XM_036163669.1XP_036019562.1  ERI1 exoribonuclease 3 isoform X14

      Conserved Domains (1) summary
      cd06133
      Location:1168
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
    7. XM_017319970.3XP_017175459.1  ERI1 exoribonuclease 3 isoform X13

      Conserved Domains (1) summary
      cd06133
      Location:1133
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
    8. XM_017319961.3XP_017175450.1  ERI1 exoribonuclease 3 isoform X4

      Conserved Domains (1) summary
      cd06133
      Location:68232
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
    9. XM_030253200.1XP_030109060.1  ERI1 exoribonuclease 3 isoform X9

      Conserved Domains (1) summary
      cd06133
      Location:68203
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
    10. XM_017319964.3XP_017175453.1  ERI1 exoribonuclease 3 isoform X4

      Conserved Domains (1) summary
      cd06133
      Location:68232
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
    11. XM_036163663.1XP_036019556.1  ERI1 exoribonuclease 3 isoform X6

      Conserved Domains (1) summary
      cd06133
      Location:68267
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
    12. XM_017319972.3XP_017175461.1  ERI1 exoribonuclease 3 isoform X16

      Conserved Domains (1) summary
      cd06133
      Location:1114
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
    13. XM_017319965.3XP_017175454.1  ERI1 exoribonuclease 3 isoform X4

      Conserved Domains (1) summary
      cd06133
      Location:68232
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
    14. XM_036163670.1XP_036019563.1  ERI1 exoribonuclease 3 isoform X15

      Conserved Domains (1) summary
      cd06133
      Location:1146
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
    15. XM_011240437.4XP_011238739.2  ERI1 exoribonuclease 3 isoform X1

      Conserved Domains (1) summary
      cd06133
      Location:146310
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
    16. XM_030253195.2XP_030109055.1  ERI1 exoribonuclease 3 isoform X3

      Conserved Domains (1) summary
      cd06133
      Location:146281
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
    17. XM_017319960.3XP_017175449.1  ERI1 exoribonuclease 3 isoform X2

      Conserved Domains (1) summary
      cd06133
      Location:144308
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
    18. XM_036163661.1XP_036019554.1  ERI1 exoribonuclease 3 isoform X6

      Conserved Domains (1) summary
      cd06133
      Location:68267
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
    19. XM_036163664.1XP_036019557.1  ERI1 exoribonuclease 3 isoform X9

      Conserved Domains (1) summary
      cd06133
      Location:68203
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
    20. XM_036163671.1XP_036019564.1  ERI1 exoribonuclease 3 isoform X16

      Related
      ENSMUST00000146384.8
      Conserved Domains (1) summary
      cd06133
      Location:1114
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
    21. XM_036163667.1XP_036019560.1  ERI1 exoribonuclease 3 isoform X13

      Conserved Domains (1) summary
      cd06133
      Location:1133
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
    22. XM_036163668.1XP_036019561.1  ERI1 exoribonuclease 3 isoform X14

      Conserved Domains (1) summary
      cd06133
      Location:1168
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
    23. XM_030253209.1XP_030109069.1  ERI1 exoribonuclease 3 isoform X16

      Conserved Domains (1) summary
      cd06133
      Location:1114
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
    24. XM_036163666.1XP_036019559.1  ERI1 exoribonuclease 3 isoform X11

      Conserved Domains (1) summary
      cd06133
      Location:35192
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
    25. XM_017319966.3XP_017175455.1  ERI1 exoribonuclease 3 isoform X4

      Conserved Domains (1) summary
      cd06133
      Location:68232
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
    26. XM_030253208.1XP_030109068.1  ERI1 exoribonuclease 3 isoform X9

      Conserved Domains (1) summary
      cd06133
      Location:68203
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
    27. XM_036163662.1XP_036019555.1  ERI1 exoribonuclease 3 isoform X7

      Conserved Domains (1) summary
      cd06133
      Location:105269
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
    28. XM_017319967.2XP_017175456.1  ERI1 exoribonuclease 3 isoform X4

      Conserved Domains (1) summary
      cd06133
      Location:68232
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins

    RNA

    1. XR_003954874.2 RNA Sequence

    2. XR_004941810.1 RNA Sequence

    3. XR_003954875.2 RNA Sequence

    4. XR_003954876.2 RNA Sequence

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