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    Eri3 exoribonuclease 3 [ Mus musculus (house mouse) ]

    Gene ID: 140546, updated on 2-Oct-2018

    Summary

    Official Symbol
    Eri3provided by MGI
    Official Full Name
    exoribonuclease 3provided by MGI
    Primary source
    MGI:MGI:2153887
    See related
    Ensembl:ENSMUSG00000033423 Vega:OTTMUSG00000008661
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PINT1; Prnpip1
    Expression
    Ubiquitous expression in CNS E18 (RPKM 32.0), ovary adult (RPKM 28.1) and 28 other tissues See more
    Orthologs

    Genomic context

    See Eri3 in Genome Data Viewer
    Location:
    4; 4 D1-D2.1
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 4 NC_000070.6 (117550285..117674297)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (117223099..117346886)

    Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene ring finger protein 220 Neighboring gene predicted gene 12827 Neighboring gene predicted gene, 34669 Neighboring gene zinc finger (CCCH type), RNA binding motif and serine/arginine rich 2 pseudogene Neighboring gene DNA methyltransferase 1-associated protein 1 Neighboring gene predicted gene, 34746

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    3'-5'-exoribonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    ERI1 exoribonuclease 3
    Names
    prion interactor 1
    prion protein interacting protein 1
    prion protein-interacting protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001285899.1NP_001272828.1  ERI1 exoribonuclease 3 isoform b

      See identical proteins and their annotated locations for NP_001272828.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in its 5' UTR, initiates translation at an alternate start codon, and uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is shorter than isoform a.
      Source sequence(s)
      BC117540, BE944838, BY255598
      UniProtKB/Swiss-Prot
      Q8C460
      Conserved Domains (1) summary
      cd06133
      Location:105282
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
    2. NM_001285901.1NP_001272830.1  ERI1 exoribonuclease 3 isoform c

      See identical proteins and their annotated locations for NP_001272830.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a. Variants 3 and 5 encode the same isoform (c).
      Source sequence(s)
      AK083017, BE944838, BY110468, BY258104
      UniProtKB/Swiss-Prot
      Q8C460
      Conserved Domains (1) summary
      cd06133
      Location:68245
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
    3. NM_001285902.1NP_001272831.1  ERI1 exoribonuclease 3 isoform d

      See identical proteins and their annotated locations for NP_001272831.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (d) is shorter at the N-terminus, compared to isoform a.
      Source sequence(s)
      AA259566, AK083017, BE944838, BY110468
      UniProtKB/Swiss-Prot
      Q8C460
      Conserved Domains (1) summary
      cd06133
      Location:1146
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
    4. NM_001356404.1NP_001343333.1  ERI1 exoribonuclease 3 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a. Variants 3 and 5 encode the same isoform (c).
      Source sequence(s)
      AK083017, BE944838, BY110468, BY288119
      Conserved Domains (1) summary
      cd06133
      Location:68245
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
    5. NM_001356405.1NP_001343334.1  ERI1 exoribonuclease 3 isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (e) has the same N- and C-termini, but is 2 aa shorter than isoform a.
      Source sequence(s)
      AK083017, BE944838, BY255598
      Conserved Domains (1) summary
      cd06133
      Location:144321
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
    6. NM_080469.4NP_536717.2  ERI1 exoribonuclease 3 isoform a

      See identical proteins and their annotated locations for NP_536717.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AK083017, BE944838, BY255598
      Consensus CDS
      CCDS18535.1
      UniProtKB/Swiss-Prot
      Q8C460
      Related
      ENSMUSP00000042796.8, OTTMUSP00000008995, ENSMUST00000037127.14, OTTMUST00000019629
      Conserved Domains (1) summary
      cd06133
      Location:146323
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000070.6 Reference GRCm38.p4 C57BL/6J

      Range
      117550285..117674297
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017319971.1XP_017175460.1  ERI1 exoribonuclease 3 isoform X9

    2. XM_017319961.1XP_017175450.1  ERI1 exoribonuclease 3 isoform X4

    3. XM_017319970.1XP_017175459.1  ERI1 exoribonuclease 3 isoform X9

    4. XM_017319964.1XP_017175453.1  ERI1 exoribonuclease 3 isoform X4

    5. XM_017319965.1XP_017175454.1  ERI1 exoribonuclease 3 isoform X4

    6. XM_017319968.1XP_017175457.1  ERI1 exoribonuclease 3 isoform X7

      Conserved Domains (1) summary
      cd06133
      Location:68245
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
    7. XM_017319962.1XP_017175451.1  ERI1 exoribonuclease 3 isoform X4

    8. XM_017319973.1XP_017175462.1  ERI1 exoribonuclease 3 isoform X11

    9. XM_017319972.1XP_017175461.1  ERI1 exoribonuclease 3 isoform X10

    10. XM_011240437.2XP_011238739.2  ERI1 exoribonuclease 3 isoform X1

    11. XM_017319960.1XP_017175449.1  ERI1 exoribonuclease 3 isoform X2

    12. XM_017319969.1XP_017175458.1  ERI1 exoribonuclease 3 isoform X8

    13. XM_017319966.1XP_017175455.1  ERI1 exoribonuclease 3 isoform X4

    14. XM_017319963.1XP_017175452.1  ERI1 exoribonuclease 3 isoform X5

      Conserved Domains (1) summary
      cd06133
      Location:144321
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
    15. XM_017319967.1XP_017175456.1  ERI1 exoribonuclease 3 isoform X4

    16. XM_011240438.1XP_011238740.1  ERI1 exoribonuclease 3 isoform X3

      Conserved Domains (1) summary
      cd06133
      Location:107306
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
    17. XM_011240442.1XP_011238744.1  ERI1 exoribonuclease 3 isoform X6

      Conserved Domains (1) summary
      cd06133
      Location:107242
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins

    RNA

    1. XR_001784088.1 RNA Sequence

    2. XR_867804.2 RNA Sequence

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