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    Pcyt1a phosphate cytidylyltransferase 1A, choline [ Rattus norvegicus (Norway rat) ]

    Gene ID: 140544, updated on 27-Nov-2024

    Summary

    Official Symbol
    Pcyt1aprovided by RGD
    Official Full Name
    phosphate cytidylyltransferase 1A, cholineprovided by RGD
    Primary source
    RGD:70515
    See related
    EnsemblRapid:ENSRNOG00000001762 AllianceGenome:RGD:70515
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    CTP; CCT-alpha
    Summary
    Enables several functions, including calmodulin binding activity; choline-phosphate cytidylyltransferase activity; and phosphatidylcholine binding activity. Involved in CDP-choline pathway. Located in nuclear envelope. Human ortholog(s) of this gene implicated in congenital generalized lipodystrophy and spondylometaphyseal dysplasia with cone-rod dystrophy. Orthologous to human PCYT1A (phosphate cytidylyltransferase 1A, choline). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 257.0), Muscle (RPKM 202.1) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Pcyt1a in Genome Data Viewer
    Location:
    11q22
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (81818914..81862623, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (68313860..68357828, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (71547865..71592037, complement)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene zinc finger DHHC-type palmitoyltransferase 19 Neighboring gene solute carrier family 51 member A Neighboring gene uncharacterized LOC120095669 Neighboring gene uncharacterized LOC134481088 Neighboring gene dynein light chain Tctex-type 2B Neighboring gene transmembrane 4 L six family member 19

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Clone Names

    • MGC93248

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calmodulin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables choline-phosphate cytidylyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables choline-phosphate cytidylyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables choline-phosphate cytidylyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables choline-phosphate cytidylyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables lipid binding EXP
    Inferred from Experiment
    more info
    PubMed 
    enables lipid binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables molecular function inhibitor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phosphatidylcholine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phosphatidylcholine binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in B cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in B cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in CDP-choline pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in CDP-choline pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in isotype switching ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in isotype switching ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in phosphatidylcholine biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in phosphatidylcholine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within phosphatidylcholine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phosphatidylcholine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phosphatidylcholine biosynthetic process TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extrinsic component of membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in glycogen granule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    choline-phosphate cytidylyltransferase A
    Names
    CCT A
    CT A
    CTP:phosphocholine cytidylyl transferase
    CTP:phosphocholine cytidylyltransferase A
    CTP:phosphocholine cytidylyltransferase alpha
    choline phosphate cytidylyltransferase 1 alpha
    choline-phosphate cytidylyltransferase A-like
    phosphate cytidylyltransferase 1, choline, alpha
    phosphorylcholine transferase A
    NP_511177.2
    XP_006248506.1
    XP_008766916.1
    XP_038943847.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_078622.2NP_511177.2  choline-phosphate cytidylyltransferase A

      See identical proteins and their annotated locations for NP_511177.2

      Status: VALIDATED

      Source sequence(s)
      AW919077, BF285251, BQ780519, L13245
      UniProtKB/Swiss-Prot
      P19836
      UniProtKB/TrEMBL
      A6IRR3, A6IRR5
      Related
      ENSRNOP00000002403.3, ENSRNOT00000002403.5
      Conserved Domains (1) summary
      cd02174
      Location:75224
      CCT; CTP:phosphocholine cytidylyltransferase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      81818914..81862623 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008768694.4XP_008766916.1  choline-phosphate cytidylyltransferase A isoform X1

      See identical proteins and their annotated locations for XP_008766916.1

      UniProtKB/Swiss-Prot
      P19836
      UniProtKB/TrEMBL
      A6IRR3, A6IRR5
      Conserved Domains (1) summary
      cd02174
      Location:75224
      CCT; CTP:phosphocholine cytidylyltransferase
    2. XM_006248444.5XP_006248506.1  choline-phosphate cytidylyltransferase A isoform X1

      See identical proteins and their annotated locations for XP_006248506.1

      UniProtKB/Swiss-Prot
      P19836
      UniProtKB/TrEMBL
      A6IRR3, A6IRR5
      Conserved Domains (1) summary
      cd02174
      Location:75224
      CCT; CTP:phosphocholine cytidylyltransferase
    3. XM_039087919.2XP_038943847.1  choline-phosphate cytidylyltransferase A isoform X1

      UniProtKB/Swiss-Prot
      P19836
      UniProtKB/TrEMBL
      A6IRR3, A6IRR5
      Conserved Domains (1) summary
      cd02174
      Location:75224
      CCT; CTP:phosphocholine cytidylyltransferase