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    Acap3 ArfGAP with coiled-coil, ankyrin repeat and PH domains 3 [ Mus musculus (house mouse) ]

    Gene ID: 140500, updated on 16-Oct-2021

    Summary

    Official Symbol
    Acap3provided by MGI
    Official Full Name
    ArfGAP with coiled-coil, ankyrin repeat and PH domains 3provided by MGI
    Primary source
    MGI:MGI:2153589
    See related
    Ensembl:ENSMUSG00000029033
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Centb5; mKIAA1716; Kiaa1716-hp
    Expression
    Ubiquitous expression in whole brain E14.5 (RPKM 26.0), CNS E18 (RPKM 24.8) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Acap3 in Genome Data Viewer
    Location:
    4 E2; 4 87.66 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (155976332..155991708)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (155891875..155907251)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (155265984..155281360)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene ceramide-1-phosphate transfer protein Neighboring gene integrator complex subunit 11 Neighboring gene pseudouridylate synthase-like 1 Neighboring gene sodium channel, nonvoltage-gated 1, delta Neighboring gene ubiquitin-conjugating enzyme E2J 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in growth cone IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3
    Names
    centaurin, beta 5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_207223.1NP_997106.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3

      See identical proteins and their annotated locations for NP_997106.1

      Status: PROVISIONAL

      Source sequence(s)
      BC067016
      Consensus CDS
      CCDS38997.1
      UniProtKB/TrEMBL
      Q6NXL5
      Related
      ENSMUSP00000101209.4, ENSMUST00000105584.10
      Conserved Domains (7) summary
      cd07637
      Location:16215
      BAR_ACAP3; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 3
      cd00204
      Location:671786
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13250
      Location:271367
      PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
      pfam00169
      Location:269363
      PH; PH domain
      pfam01412
      Location:403521
      ArfGap; Putative GTPase activating protein for Arf
      pfam12796
      Location:671764
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:700731
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      155976332..155991708
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006538541.5XP_006538604.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006538604.1

      Related
      ENSMUST00000137726.8
      Conserved Domains (5) summary
      PTZ00322
      Location:663758
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      cd13250
      Location:229325
      PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
      sd00045
      Location:658689
      ANK; ANK repeat [structural motif]
      cd08850
      Location:361476
      ArfGap_ACAP3; ArfGAP domain of ACAP3 (ArfGAP with Coiled-coil, ANK repeat and PH domains 3)
      cl12013
      Location:1173
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    2. XM_006538542.3XP_006538605.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006538605.1

      Conserved Domains (5) summary
      PTZ00322
      Location:663758
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      cd13250
      Location:229325
      PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
      sd00045
      Location:658689
      ANK; ANK repeat [structural motif]
      cd08850
      Location:361476
      ArfGap_ACAP3; ArfGAP domain of ACAP3 (ArfGAP with Coiled-coil, ANK repeat and PH domains 3)
      cl12013
      Location:1173
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
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