Format

Send to:

Choose Destination
    • Showing Current items.

    Eya3 EYA transcriptional coactivator and phosphatase 3 [ Mus musculus (house mouse) ]

    Gene ID: 14050, updated on 2-Oct-2018

    Summary

    Official Symbol
    Eya3provided by MGI
    Official Full Name
    EYA transcriptional coactivator and phosphatase 3provided by MGI
    Primary source
    MGI:MGI:109339
    See related
    Ensembl:ENSMUSG00000028886 Vega:OTTMUSG00000009803
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI844637
    Expression
    Ubiquitous expression in thymus adult (RPKM 11.7), limb E14.5 (RPKM 11.5) and 28 other tissues See more
    Orthologs

    Genomic context

    See Eya3 in Genome Data Viewer
    Location:
    4 D2.3; 4 65.68 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 4 NC_000070.6 (132639014..132724765)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (132194961..132280678)

    Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene DnaJ heat shock protein family (Hsp40) member C8 Neighboring gene platelet-activating factor receptor Neighboring gene sphingomyelin phosphodiesterase, acid-like 3B Neighboring gene X-linked Kx blood group related 8

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    chromatin binding IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein tyrosine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein tyrosine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein tyrosine/serine/threonine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    anatomical structure development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cellular response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    chromatin organization IEA
    Inferred from Electronic Annotation
    more info
     
    double-strand break repair ISO
    Inferred from Sequence Orthology
    more info
     
    histone dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    histone dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of DNA repair ISO
    Inferred from Sequence Orthology
    more info
     
    protein dephosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to ionizing radiation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 

    General protein information

    Preferred Names
    eyes absent homolog 3
    Names
    eyes absent 3 homolog
    NP_034296.2
    NP_997592.1
    NP_997596.1
    XP_006538600.1
    XP_006538601.1
    XP_006538603.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010166.3NP_034296.2  eyes absent homolog 3 isoform 2

      See identical proteins and their annotated locations for NP_034296.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2 which has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AL627130, BB599684
      Consensus CDS
      CCDS18730.1
      UniProtKB/Swiss-Prot
      P97480
      Related
      ENSMUSP00000078157.4, ENSMUST00000079157.10
      Conserved Domains (1) summary
      TIGR01658
      Location:239510
      EYA-cons_domain; eyes absent protein conserved domain
    2. NM_210071.2NP_997592.1  eyes absent homolog 3 isoform 1

      See identical proteins and their annotated locations for NP_997592.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AK164591, AL627130, BB599684, BC063259, CK639946
      Consensus CDS
      CCDS18729.1
      UniProtKB/TrEMBL
      Q3TP96, Q6P4T3
      Related
      ENSMUSP00000080425.6, OTTMUSP00000010370, ENSMUST00000081726.12, OTTMUST00000022722
      Conserved Domains (1) summary
      TIGR01658
      Location:255526
      EYA-cons_domain; eyes absent protein conserved domain
    3. NM_211357.2NP_997596.1  eyes absent homolog 3 isoform 3

      See identical proteins and their annotated locations for NP_997596.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two alternate exons in the 5' coding region and initiates translation at an alternate start codon, compared to variant 1. It encodes isoform 3, which is shorter and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AL627130, BB599684, BC063259, BY730487, CK639946
      Consensus CDS
      CCDS18731.1
      UniProtKB/TrEMBL
      Q6P4T3
      Related
      ENSMUSP00000020197.7, ENSMUST00000020197.13
      Conserved Domains (1) summary
      TIGR01658
      Location:145416
      EYA-cons_domain; eyes absent protein conserved domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000070.6 Reference GRCm38.p4 C57BL/6J

      Range
      132639014..132724765
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006538538.3XP_006538601.1  eyes absent homolog 3 isoform X2

      Conserved Domains (1) summary
      TIGR01658
      Location:285556
      EYA-cons_domain; eyes absent protein conserved domain
    2. XM_006538537.3XP_006538600.1  eyes absent homolog 3 isoform X1

      Conserved Domains (1) summary
      TIGR01658
      Location:301572
      EYA-cons_domain; eyes absent protein conserved domain
    3. XM_006538540.3XP_006538603.1  eyes absent homolog 3 isoform X3

      Related
      ENSMUSP00000123045.1, OTTMUSP00000010550, ENSMUST00000135299.7, OTTMUST00000023136
      Conserved Domains (1) summary
      TIGR01658
      Location:301360
      EYA-cons_domain; eyes absent protein conserved domain

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_211356.1: Suppressed sequence

      Description
      NM_211356.1: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.
    Support Center