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    Eya3 EYA transcriptional coactivator and phosphatase 3 [ Mus musculus (house mouse) ]

    Gene ID: 14050, updated on 26-Sep-2022

    Summary

    Official Symbol
    Eya3provided by MGI
    Official Full Name
    EYA transcriptional coactivator and phosphatase 3provided by MGI
    Primary source
    MGI:MGI:109339
    See related
    Ensembl:ENSMUSG00000028886 AllianceGenome:MGI:109339
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables chromatin binding activity; protein tyrosine phosphatase activity; and protein tyrosine/serine/threonine phosphatase activity. Acts upstream of or within protein dephosphorylation. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including branchial arch; genitourinary system; limb bud; rhombomere; and sensory organ. Orthologous to human EYA3 (EYA transcriptional coactivator and phosphatase 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in thymus adult (RPKM 11.7), limb E14.5 (RPKM 11.5) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Eya3 in Genome Data Viewer
    Location:
    4 D2.3; 4 65.68 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (132366303..132452076)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (132639025..132724765)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene DnaJ heat shock protein family (Hsp40) member C8 Neighboring gene predicted gene, 54261 Neighboring gene platelet-activating factor receptor Neighboring gene sphingomyelin phosphodiesterase, acid-like 3B Neighboring gene X-linked Kx blood group related 8

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1)  1 citation
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables chromatin binding IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    enables histone H2Y142 phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein tyrosine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein tyrosine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein tyrosine/serine/threonine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of transcription regulator complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 

    General protein information

    Preferred Names
    eyes absent homolog 3
    Names
    eyes absent 3 homolog
    NP_034296.2
    NP_997592.1
    NP_997596.1
    XP_006538600.1
    XP_006538601.1
    XP_006538603.1
    XP_036019552.1
    XP_036019553.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001403755.1NP_001390684.1  eyes absent homolog 3 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL627130
    2. NM_001403756.1NP_001390685.1  eyes absent homolog 3 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL627130
    3. NM_001403757.1NP_001390686.1  eyes absent homolog 3 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL627130
    4. NM_001403758.1NP_001390687.1  eyes absent homolog 3 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL627130
    5. NM_001403759.1NP_001390688.1  eyes absent homolog 3 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL627130
    6. NM_001403760.1NP_001390689.1  eyes absent homolog 3 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AL627130
    7. NM_010166.4NP_034296.2  eyes absent homolog 3 isoform 2

      See identical proteins and their annotated locations for NP_034296.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2 which has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AL627130
      Consensus CDS
      CCDS18730.1
      UniProtKB/Swiss-Prot
      P97480, P97768
      Related
      ENSMUSP00000078157.5, ENSMUST00000079157.11
      Conserved Domains (1) summary
      TIGR01658
      Location:239510
      EYA-cons_domain; eyes absent protein conserved domain
    8. NM_210071.3NP_997592.1  eyes absent homolog 3 isoform 1

      See identical proteins and their annotated locations for NP_997592.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AL627130
      Consensus CDS
      CCDS18729.1
      UniProtKB/TrEMBL
      Q3TP96, Q6P4T3
      Related
      ENSMUSP00000080425.7, ENSMUST00000081726.13
      Conserved Domains (1) summary
      TIGR01658
      Location:255526
      EYA-cons_domain; eyes absent protein conserved domain
    9. NM_211357.3NP_997596.1  eyes absent homolog 3 isoform 3

      See identical proteins and their annotated locations for NP_997596.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two alternate exons in the 5' coding region and initiates translation at an alternate start codon, compared to variant 1. It encodes isoform 3, which is shorter and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AL627130
      Consensus CDS
      CCDS18731.1
      UniProtKB/TrEMBL
      Q6P4T3
      Related
      ENSMUSP00000020197.8, ENSMUST00000020197.14
      Conserved Domains (1) summary
      TIGR01658
      Location:145416
      EYA-cons_domain; eyes absent protein conserved domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      132366303..132452076
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006538537.5XP_006538600.1  eyes absent homolog 3 isoform X1

      Conserved Domains (2) summary
      TIGR01658
      Location:301572
      EYA-cons_domain; eyes absent protein conserved domain
      pfam09606
      Location:8139
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    2. XM_006538540.5XP_006538603.1  eyes absent homolog 3 isoform X5

      Related
      ENSMUSP00000123045.2, ENSMUST00000135299.8
      Conserved Domains (1) summary
      TIGR01658
      Location:301360
      EYA-cons_domain; eyes absent protein conserved domain
    3. XM_006538538.5XP_006538601.1  eyes absent homolog 3 isoform X2

      Conserved Domains (2) summary
      TIGR01658
      Location:285556
      EYA-cons_domain; eyes absent protein conserved domain
      pfam03154
      Location:59254
      Atrophin-1; Atrophin-1 family
    4. XM_036163659.1XP_036019552.1  eyes absent homolog 3 isoform X3

      Conserved Domains (1) summary
      TIGR01658
      Location:253524
      EYA-cons_domain; eyes absent protein conserved domain
    5. XM_036163660.1XP_036019553.1  eyes absent homolog 3 isoform X4

      Conserved Domains (2) summary
      TIGR01658
      Location:207478
      EYA-cons_domain; eyes absent protein conserved domain
      cl41773
      Location:35116
      SP1-4_N; N-terminal domain of transcription factor Specificity Proteins (SP) 1-4

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_211356.1: Suppressed sequence

      Description
      NM_211356.1: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.