Format

Send to:

Choose Destination
    • Showing Current items.

    Evl Ena-vasodilator stimulated phosphoprotein [ Mus musculus (house mouse) ]

    Gene ID: 14026, updated on 7-Aug-2018

    Summary

    Official Symbol
    Evlprovided by MGI
    Official Full Name
    Ena-vasodilator stimulated phosphoproteinprovided by MGI
    Primary source
    MGI:MGI:1194884
    See related
    Ensembl:ENSMUSG00000021262
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI528774; b2b2600Clo
    Expression
    Broad expression in whole brain E14.5 (RPKM 64.8), CNS E14 (RPKM 64.7) and 27 other tissues See more
    Orthologs

    Genomic context

    See Evl in Genome Data Viewer
    Location:
    12; 12 F1
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 12 NC_000078.6 (108554720..108688516)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (109792930..109926726)

    Chromosome 12 - NC_000078.6Genomic Context describing neighboring genes Neighboring gene cytochrome P450, family 46, subfamily a, polypeptide 1 Neighboring gene echinoderm microtubule associated protein like 1 Neighboring gene bridging integrator 3 pseudogene Neighboring gene predicted gene, 16596 Neighboring gene microRNA 342 Neighboring gene predicted gene, 40571 Neighboring gene predicted gene, 33467 Neighboring gene delta(4)-desaturase, sphingolipid 2 Neighboring gene predicted gene, 40572

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (4)  1 citation
    • Chemically induced (ENU) (1) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    SH3 domain binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    profilin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    actin filament-based movement NAS
    Non-traceable Author Statement
    more info
    PubMed 
    actin nucleation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    actin polymerization or depolymerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    axon guidance NAS
    Non-traceable Author Statement
    more info
    PubMed 
    barbed-end actin filament capping NAS
    Non-traceable Author Statement
    more info
    PubMed 
    cellular response to interferon-gamma IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of epithelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of ruffle assembly ISO
    Inferred from Sequence Orthology
    more info
     
    platelet activation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    positive regulation of actin filament polymerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of stress fiber assembly ISO
    Inferred from Sequence Orthology
    more info
     
    protein homotetramerization IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    focal adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lamellipodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phagocytic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163394.1NP_001156866.1  ena/VASP-like protein isoform 1

      See identical proteins and their annotated locations for NP_001156866.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      BC059810, BC096017
      Consensus CDS
      CCDS49167.1
      UniProtKB/Swiss-Prot
      P70429
      UniProtKB/TrEMBL
      Q6PB99
      Related
      ENSMUSP00000021689.6, ENSMUST00000021689.13
      Conserved Domains (2) summary
      cd01207
      Location:5113
      EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
      pfam08776
      Location:377409
      VASP_tetra; VASP tetramerization domain
    2. NM_001163395.1NP_001156867.1  ena/VASP-like protein isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate exon in the 5' coding region, uses a downstream start codon, and lacks an in-frame exon in the 3' coding region, compared to isoform 1. This results in a shorter protein (isoform 3), compared to isoform 1.
      Source sequence(s)
      AK134563, BC059810
      Consensus CDS
      CCDS49168.1
      UniProtKB/TrEMBL
      F8WJB9, Q6PB99
      Related
      ENSMUSP00000105480.2, ENSMUST00000109854.8
      Conserved Domains (2) summary
      cd01207
      Location:11119
      EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
      pfam08776
      Location:362394
      VASP_tetra; VASP tetramerization domain
    3. NM_001163396.2NP_001156868.1  ena/VASP-like protein isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains alternate exons in the 5' coding region and uses a downstream start codon, compared to variant 1. This results in a shorter protein (isoform 4), compared to isoform 1.
      Source sequence(s)
      AK134563, AK151633, BC059810
      Consensus CDS
      CCDS49169.1
      UniProtKB/TrEMBL
      E9PVP4, Q6PB99
      Related
      ENSMUSP00000133072.1, ENSMUST00000172409.1
      Conserved Domains (2) summary
      cd01207
      Location:1100
      EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
      pfam08776
      Location:364396
      VASP_tetra; VASP tetramerization domain
    4. NM_007965.3NP_031991.3  ena/VASP-like protein isoform 2

      See identical proteins and their annotated locations for NP_031991.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      BC059810, BC096017
      Consensus CDS
      CCDS26161.1
      UniProtKB/Swiss-Prot
      P70429
      UniProtKB/TrEMBL
      Q6PB99
      Related
      ENSMUSP00000076916.5, ENSMUST00000077735.12
      Conserved Domains (2) summary
      cd01207
      Location:5113
      EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
      pfam08776
      Location:356388
      VASP_tetra; VASP tetramerization domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000078.6 Reference GRCm38.p4 C57BL/6J

      Range
      108554720..108688516
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006515470.1XP_006515533.1  ena/VASP-like protein isoform X1

      Conserved Domains (2) summary
      cd01207
      Location:11119
      EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
      pfam08776
      Location:383415
      VASP_tetra; VASP tetramerization domain
    2. XM_006515471.1XP_006515534.1  ena/VASP-like protein isoform X2

      Related
      ENSMUSP00000152364.1, ENSMUST00000223109.1
      Conserved Domains (2) summary
      cd01207
      Location:7115
      EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
      pfam08776
      Location:379411
      VASP_tetra; VASP tetramerization domain
    Support Center