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    Evi5 ecotropic viral integration site 5 [ Mus musculus (house mouse) ]

    Gene ID: 14020, updated on 23-Jun-2021

    Summary

    Official Symbol
    Evi5provided by MGI
    Official Full Name
    ecotropic viral integration site 5provided by MGI
    Primary source
    MGI:MGI:104736
    See related
    Ensembl:ENSMUSG00000011831
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NB; NB4S
    Expression
    Ubiquitous expression in frontal lobe adult (RPKM 3.7), placenta adult (RPKM 3.6) and 27 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Evi5 in Genome Data Viewer
    Location:
    5 F; 5 52.23 cM
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (107892661..108022973, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (107744795..107875107, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (108173814..108304126, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene -8.7 kb enhancer upstream of Gfi1 Neighboring gene predicted gene, 42147 Neighboring gene Gfi1 -35 kb enhancer Neighboring gene ubiquitin-conjugating enzyme E2D 2B Neighboring gene predicted gene, 42149 Neighboring gene small nucleolar RNA, C/D box 21 Neighboring gene predicted gene, 22270 Neighboring gene ribosomal protein L5

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in activation of GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in retrograde transport, endosome to Golgi ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    ecotropic viral integration site 5 protein
    Names
    EVI-5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001378824.1NP_001365753.1  ecotropic viral integration site 5 protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC138666
      Conserved Domains (2) summary
      smart00164
      Location:116324
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      COG1196
      Location:348693
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    2. NM_001378825.1NP_001365754.1  ecotropic viral integration site 5 protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC138666
      Conserved Domains (2) summary
      smart00164
      Location:116324
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      TIGR02168
      Location:361670
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    3. NM_007964.2NP_031990.2  ecotropic viral integration site 5 protein isoform 1

      See identical proteins and their annotated locations for NP_031990.2

      Status: VALIDATED

      Source sequence(s)
      AC117574, AC138666, AK134294, BI737814, CN456828, CV557033
      Consensus CDS
      CCDS39198.1
      UniProtKB/TrEMBL
      F8VPT6, Q3UYX4
      Related
      ENSMUSP00000108261.2, ENSMUST00000112642.8
      Conserved Domains (3) summary
      smart00164
      Location:160368
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      pfam06386
      Location:527674
      GvpL_GvpF; Gas vesicle synthesis protein GvpL/GvpF
      cl11555
      Location:456494
      DUF1129; Protein of unknown function (DUF1129)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      107892661..108022973 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006534781.3XP_006534844.1  ecotropic viral integration site 5 protein isoform X5

      Conserved Domains (2) summary
      smart00164
      Location:160368
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      TIGR02168
      Location:406709
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    2. XM_006534776.4XP_006534839.1  ecotropic viral integration site 5 protein isoform X1

      Conserved Domains (2) summary
      smart00164
      Location:160368
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      COG1196
      Location:392737
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    3. XM_006534783.5XP_006534846.1  ecotropic viral integration site 5 protein isoform X6

      Conserved Domains (2) summary
      smart00164
      Location:160368
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      COG1196
      Location:392737
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    4. XM_006534780.5XP_006534843.1  ecotropic viral integration site 5 protein isoform X4

      Conserved Domains (2) summary
      smart00164
      Location:160368
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      TIGR02168
      Location:389714
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    5. XM_006534779.4XP_006534842.1  ecotropic viral integration site 5 protein isoform X3

      See identical proteins and their annotated locations for XP_006534842.1

      Conserved Domains (2) summary
      smart00164
      Location:116324
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      COG1196
      Location:348693
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    6. XM_011249407.4XP_011247709.1  ecotropic viral integration site 5 protein isoform X3

      See identical proteins and their annotated locations for XP_011247709.1

      Conserved Domains (2) summary
      smart00164
      Location:116324
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      COG1196
      Location:348693
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    7. XM_006534777.5XP_006534840.1  ecotropic viral integration site 5 protein isoform X2

      Conserved Domains (2) summary
      smart00164
      Location:144352
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      COG1196
      Location:376721
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    8. XM_030254127.2XP_030109987.1  ecotropic viral integration site 5 protein isoform X9

      Conserved Domains (2) summary
      smart00164
      Location:116324
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      TIGR02168
      Location:362658
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    9. XM_006534784.4XP_006534847.1  ecotropic viral integration site 5 protein isoform X7

      Conserved Domains (2) summary
      smart00164
      Location:71279
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      COG1196
      Location:303648
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    10. XM_006534785.5XP_006534848.1  ecotropic viral integration site 5 protein isoform X8

      Conserved Domains (2) summary
      smart00164
      Location:160368
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      COG1196
      Location:392737
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    11. XM_006534786.2XP_006534849.1  ecotropic viral integration site 5 protein isoform X10

      Related
      ENSMUSP00000114845.2, ENSMUST00000128723.8
      Conserved Domains (2) summary
      smart00164
      Location:160368
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      TIGR02168
      Location:389731
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    12. XM_011249408.4XP_011247710.1  ecotropic viral integration site 5 protein isoform X11

      Conserved Domains (2) summary
      smart00164
      Location:160368
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      TIGR02168
      Location:389731
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    13. XM_006534787.4XP_006534850.1  ecotropic viral integration site 5 protein isoform X12

      Related
      ENSMUSP00000119196.2, ENSMUST00000138111.8
      Conserved Domains (1) summary
      smart00164
      Location:160368
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    14. XM_036164779.1XP_036020672.1  ecotropic viral integration site 5 protein isoform X13

      Related
      ENSMUSP00000121761.2, ENSMUST00000124034.8
      Conserved Domains (1) summary
      smart00164
      Location:116324
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
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