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    Evi5 ecotropic viral integration site 5 [ Mus musculus (house mouse) ]

    Gene ID: 14020, updated on 31-Jan-2019

    Summary

    Official Symbol
    Evi5provided by MGI
    Official Full Name
    ecotropic viral integration site 5provided by MGI
    Primary source
    MGI:MGI:104736
    See related
    Ensembl:ENSMUSG00000011831
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NB4S
    Expression
    Ubiquitous expression in frontal lobe adult (RPKM 3.7), placenta adult (RPKM 3.6) and 27 other tissues See more
    Orthologs

    Genomic context

    See Evi5 in Genome Data Viewer
    Location:
    5 F; 5 52.23 cM
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (107744795..107875107, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (108173814..108304126, complement)

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A430072P03 gene Neighboring gene growth factor independent 1 transcription repressor Neighboring gene predicted gene, 42147 Neighboring gene ubiquitin-conjugating enzyme E2D 2B Neighboring gene predicted gene, 42149 Neighboring gene divergent protein kinase domain 1A Neighboring gene ribosomal protein L5 Neighboring gene predicted gene, 42150

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    Rab GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Rab GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    activation of GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    retrograde transport, endosome to Golgi ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    ecotropic viral integration site 5 protein
    Names
    EVI-5

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007964.2NP_031990.2  ecotropic viral integration site 5 protein

      See identical proteins and their annotated locations for NP_031990.2

      Status: VALIDATED

      Source sequence(s)
      AC117574, AC138666, AK134294, BI737814, CN456828, CV557033
      Consensus CDS
      CCDS39198.1
      UniProtKB/TrEMBL
      F8VPT6, Q3UYX4
      Related
      ENSMUSP00000108261.1, ENSMUST00000112642.7
      Conserved Domains (3) summary
      smart00164
      Location:160368
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      pfam06386
      Location:527674
      GvpL_GvpF; Gas vesicle synthesis protein GvpL/GvpF
      cl11555
      Location:456494
      DUF1129; Protein of unknown function (DUF1129)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

      Range
      107744795..107875107 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006534781.2XP_006534844.1  ecotropic viral integration site 5 protein isoform X5

      Conserved Domains (3) summary
      smart00164
      Location:160368
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      pfam00261
      Location:476688
      Tropomyosin; Tropomyosin
      cl11555
      Location:516554
      DUF1129; Protein of unknown function (DUF1129)
    2. XM_017320659.1XP_017176148.1  ecotropic viral integration site 5 protein isoform X11

    3. XM_017320660.1XP_017176149.1  ecotropic viral integration site 5 protein isoform X12

    4. XM_006534776.3XP_006534839.1  ecotropic viral integration site 5 protein isoform X1

      Conserved Domains (3) summary
      smart00164
      Location:160368
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      pfam06386
      Location:587734
      GvpL_GvpF; Gas vesicle synthesis protein GvpL/GvpF
      cl11555
      Location:516554
      DUF1129; Protein of unknown function (DUF1129)
    5. XM_006534780.3XP_006534843.1  ecotropic viral integration site 5 protein isoform X4

      Conserved Domains (3) summary
      smart00164
      Location:160368
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      pfam06386
      Location:538685
      GvpL_GvpF; Gas vesicle synthesis protein GvpL/GvpF
      cl11555
      Location:467505
      DUF1129; Protein of unknown function (DUF1129)
    6. XM_006534783.3XP_006534846.1  ecotropic viral integration site 5 protein isoform X6

      Conserved Domains (3) summary
      smart00164
      Location:160368
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      pfam06386
      Location:587734
      GvpL_GvpF; Gas vesicle synthesis protein GvpL/GvpF
      cl11555
      Location:516554
      DUF1129; Protein of unknown function (DUF1129)
    7. XM_006534785.3XP_006534848.1  ecotropic viral integration site 5 protein isoform X8

      Conserved Domains (3) summary
      smart00164
      Location:160368
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      pfam06386
      Location:587734
      GvpL_GvpF; Gas vesicle synthesis protein GvpL/GvpF
      cl11555
      Location:516554
      DUF1129; Protein of unknown function (DUF1129)
    8. XM_006534779.3XP_006534842.1  ecotropic viral integration site 5 protein isoform X3

      See identical proteins and their annotated locations for XP_006534842.1

      Conserved Domains (2) summary
      smart00164
      Location:116324
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      cl11555
      Location:472510
      DUF1129; Protein of unknown function (DUF1129)
    9. XM_011249407.2XP_011247709.1  ecotropic viral integration site 5 protein isoform X3

      See identical proteins and their annotated locations for XP_011247709.1

      Conserved Domains (2) summary
      smart00164
      Location:116324
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      cl11555
      Location:472510
      DUF1129; Protein of unknown function (DUF1129)
    10. XM_006534778.3XP_006534841.1  ecotropic viral integration site 5 protein isoform X3

      See identical proteins and their annotated locations for XP_006534841.1

      Conserved Domains (2) summary
      smart00164
      Location:116324
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      cl11555
      Location:472510
      DUF1129; Protein of unknown function (DUF1129)
    11. XM_006534784.3XP_006534847.1  ecotropic viral integration site 5 protein isoform X7

      Conserved Domains (3) summary
      smart00164
      Location:71279
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      pfam06386
      Location:498645
      GvpL_GvpF; Gas vesicle synthesis protein GvpL/GvpF
      cl11555
      Location:427465
      DUF1129; Protein of unknown function (DUF1129)
    12. XM_006534777.3XP_006534840.1  ecotropic viral integration site 5 protein isoform X2

      Conserved Domains (3) summary
      smart00164
      Location:144352
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      pfam06386
      Location:571718
      GvpL_GvpF; Gas vesicle synthesis protein GvpL/GvpF
      cl11555
      Location:500538
      DUF1129; Protein of unknown function (DUF1129)
    13. XM_006534786.1XP_006534849.1  ecotropic viral integration site 5 protein isoform X9

      Related
      ENSMUSP00000114845.1, ENSMUST00000128723.7
      Conserved Domains (3) summary
      smart00164
      Location:160368
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      pfam06386
      Location:587734
      GvpL_GvpF; Gas vesicle synthesis protein GvpL/GvpF
      cl11555
      Location:516554
      DUF1129; Protein of unknown function (DUF1129)
    14. XM_011249408.2XP_011247710.1  ecotropic viral integration site 5 protein isoform X10

      Conserved Domains (3) summary
      smart00164
      Location:160368
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      pfam06386
      Location:587734
      GvpL_GvpF; Gas vesicle synthesis protein GvpL/GvpF
      cl11555
      Location:516554
      DUF1129; Protein of unknown function (DUF1129)
    15. XM_006534787.3XP_006534850.1  ecotropic viral integration site 5 protein isoform X13

      Related
      ENSMUSP00000119196.1, ENSMUST00000138111.7
      Conserved Domains (1) summary
      smart00164
      Location:160368
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
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