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    CRK CRK proto-oncogene, adaptor protein [ Homo sapiens (human) ]

    Gene ID: 1398, updated on 5-Mar-2024

    Summary

    Official Symbol
    CRKprovided by HGNC
    Official Full Name
    CRK proto-oncogene, adaptor proteinprovided by HGNC
    Primary source
    HGNC:HGNC:2362
    See related
    Ensembl:ENSG00000167193 MIM:164762; AllianceGenome:HGNC:2362
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    p38; CRKII
    Summary
    This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in fat (RPKM 27.5), thyroid (RPKM 27.2) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See CRK in Genome Data Viewer
    Location:
    17p13.3
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (1420693..1456232, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (1309416..1344954, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (1323987..1359526, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:1202102-1202696 Neighboring gene trafficking regulator of GLUT4 (SLC2A4) 1 Neighboring gene Sharpr-MPRA regulatory region 14526 Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:1295206-1295734 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:1302101-1302738 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:1302739-1303376 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:1303377-1304014 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:1304957-1305572 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr17:1305573-1306188 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:1335344-1335844 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:1335845-1336345 Neighboring gene Sharpr-MPRA regulatory region 4720 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:1357059-1357560 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:1358695-1359680 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11449 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:1366499-1367318 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:1371831-1372451 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7954 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11450 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11451 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11452 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7955 Neighboring gene myosin IC Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7956 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7957 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:1394312-1395031 Neighboring gene uncharacterized LOC105371483 Neighboring gene inositol polyphosphate-5-phosphatase K

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ38130

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables SH2 domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables SH3 domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables cytoskeletal protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ephrin receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables insulin-like growth factor receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables phosphotyrosine residue binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein phosphorylated amino acid binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein self-association IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein tyrosine kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables receptor tyrosine kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables scaffold protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables signaling adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables signaling adaptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables signaling receptor complex adaptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to endothelin IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to insulin-like growth factor stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to nerve growth factor stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to nitric oxide IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to transforming growth factor beta stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cerebellar neuron development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cerebral cortex development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in dendrite development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ephrin receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in establishment of cell polarity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in helper T cell diapedesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in hippocampus development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cell motility IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of cell motility IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of natural killer cell mediated cytotoxicity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of wound healing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of wound healing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neuron migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of JNK cascade IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of Rac protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of skeletal muscle acetylcholine-gated channel clustering IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of smooth muscle cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of substrate adhesion-dependent cell spreading IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in postsynaptic specialization assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein localization to membrane IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in reelin-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of GTPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of T cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of actin cytoskeleton organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of cell adhesion mediated by integrin IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of cell shape IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of dendrite development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of intracellular signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of protein binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in response to cholecystokinin IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to hepatocyte growth factor IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to hydrogen peroxide IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to yeast IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IC
    Inferred by Curator
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in neuromuscular junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    part_of protein-containing complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 

    General protein information

    Preferred Names
    adapter molecule crk
    Names
    proto-oncogene c-Crk
    v-crk avian sarcoma virus CT10 oncogene homolog
    v-crk sarcoma virus CT10 oncogene-like protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029008.1 RefSeqGene

      Range
      5019..40558
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_005206.5NP_005197.3  adapter molecule crk isoform b

      See identical proteins and their annotated locations for NP_005197.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (I) represents the shorter transcript and encodes the shorter isoform (b). Isoform b increases transformation activity due to the loss of a SH3 domain.
      Source sequence(s)
      AC032044, AK291060
      Consensus CDS
      CCDS45561.1
      UniProtKB/TrEMBL
      A0A0S2Z3K9
      Related
      ENSP00000381942.5, ENST00000398970.5
      Conserved Domains (2) summary
      cd09926
      Location:5122
      SH2_CRK_like; Src homology 2 domain found in cancer-related signaling adaptor protein CRK
      cd11758
      Location:135189
      SH3_CRK_N; N-terminal Src Homology 3 domain of Ct10 Regulator of Kinase adaptor proteins
    2. NM_016823.4NP_058431.2  adapter molecule crk isoform a

      See identical proteins and their annotated locations for NP_058431.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (II) includes an alternate segment, compared to variant I, resulting in a longer protein (isoform a) that has a distinct C-terminus and an additional SH3 domain, compared to isoform b. Isoform a is a negative modulator of transformation activity.
      Source sequence(s)
      AC032044, AU125411, BC008506
      Consensus CDS
      CCDS11002.1
      UniProtKB/Swiss-Prot
      A8MWE8, B0LPE8, D3DTH6, P46108, Q96GA9, Q96HJ0
      UniProtKB/TrEMBL
      A0A0S2Z3Q4, L7RT18
      Related
      ENSP00000300574.2, ENST00000300574.3
      Conserved Domains (3) summary
      cd09926
      Location:5122
      SH2_CRK_like; Src homology 2 domain found in cancer-related signaling adaptor protein CRK
      cd11758
      Location:135189
      SH3_CRK_N; N-terminal Src Homology 3 domain of Ct10 Regulator of Kinase adaptor proteins
      cd11759
      Location:237293
      SH3_CRK_C; C-terminal Src Homology 3 domain of Ct10 Regulator of Kinase adaptor proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      1420693..1456232 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_187613.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      362719..379185 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      1309416..1344954 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)