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    CRIP1 cysteine rich protein 1 [ Homo sapiens (human) ]

    Gene ID: 1396, updated on 19-Jun-2024

    Summary

    Official Symbol
    CRIP1provided by HGNC
    Official Full Name
    cysteine rich protein 1provided by HGNC
    Primary source
    HGNC:HGNC:2360
    See related
    Ensembl:ENSG00000213145 MIM:123875; AllianceGenome:HGNC:2360
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CRHP; CRIP; CRP1; CRP-1
    Summary
    Cysteine-rich intestinal protein (CRIP) belongs to the LIM/double zinc finger protein family, members of which include cysteine- and glycine-rich protein-1 (CSRP1; MIM 123876), rhombotin-1 (RBTN1; MIM 186921), rhombotin-2 (RBTN2; MIM 180385), and rhombotin-3 (RBTN3; MIM 180386). CRIP may be involved in intestinal zinc transport (Hempe and Cousins, 1991 [PubMed 1946385]).[supplied by OMIM, Mar 2008]
    Expression
    Broad expression in small intestine (RPKM 154.6), lung (RPKM 120.1) and 20 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See CRIP1 in Genome Data Viewer
    Location:
    14q32.33
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (105486886..105488947)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (99736255..99738315)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (105953223..105955284)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6237 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:105887709-105888376 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:105888377-105889046 Neighboring gene metastasis associated 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:105903142-105903739 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:105903740-105904336 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6238 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:105930591-105931113 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:105931114-105931635 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:105937181-105938044 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:105939600-105940132 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6239 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6240 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6241 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6242 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6243 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:105947154-105947875 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9149 Neighboring gene cysteine rich protein 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6245 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6246 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6247 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6248 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:105954409-105954980 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6249 Neighboring gene hESC enhancers GRCh37_chr14:105956919-105957662 and GRCh37_chr14:105957663-105958406 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6250 Neighboring gene Sharpr-MPRA regulatory region 9919 Neighboring gene tubulin epsilon and delta complex 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:105974095-105974596 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:105974597-105975096 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:105978261-105978760 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:105986957-105987132 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6253 Neighboring gene transmembrane protein 121

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ40971

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables peptide binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables zinc ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    cysteine-rich protein 1
    Names
    cysteine-rich heart protein
    cysteine-rich intestinal protein
    cysteine-rich protein 1 (intestinal)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001311.5NP_001302.1  cysteine-rich protein 1

      See identical proteins and their annotated locations for NP_001302.1

      Status: VALIDATED

      Source sequence(s)
      AL928654, BC002738, BQ128075, BU500642
      Consensus CDS
      CCDS10004.1
      UniProtKB/Swiss-Prot
      H3BPI2, P50238, Q13628, Q53XY7, Q96J34
      Related
      ENSP00000376315.3, ENST00000392531.4
      Conserved Domains (1) summary
      cd09478
      Location:457
      LIM_CRIP; The LIM domain of Cysteine-Rich Intestinal Protein (CRIP)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      105486886..105488947
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      99736255..99738315
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)