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    CREBBP CREB binding protein [ Homo sapiens (human) ]

    Gene ID: 1387, updated on 26-Jul-2021

    Summary

    Official Symbol
    CREBBPprovided by HGNC
    Official Full Name
    CREB binding proteinprovided by HGNC
    Primary source
    HGNC:HGNC:2348
    See related
    Ensembl:ENSG00000005339 MIM:600140
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CBP; RSTS; KAT3A; MKHK1; RSTS1
    Summary
    This gene is ubiquitously expressed and is involved in the transcriptional coactivation of many different transcription factors. First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. The protein encoded by this gene has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. This protein acetylates both histone and non-histone proteins. This protein shares regions of very high sequence similarity with protein p300 in its bromodomain, cysteine-histidine-rich regions, and histone acetyltransferase domain. Mutations in this gene cause Rubinstein-Taybi syndrome (RTS). Chromosomal translocations involving this gene have been associated with acute myeloid leukemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2009]
    Expression
    Ubiquitous expression in testis (RPKM 12.8), bone marrow (RPKM 12.2) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See CREBBP in Genome Data Viewer
    Location:
    16p13.3
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (3725054..3880727, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (3775055..3930714, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371060 Neighboring gene SLX4 structure-specific endonuclease subunit Neighboring gene deoxyribonuclease 1 Neighboring gene TNF receptor associated protein 1 Neighboring gene long intergenic non-protein coding RNA 2861 Neighboring gene adenylate cyclase 9

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Drug-gene interactions and the search for missing heritability: a cross-sectional pharmacogenomics study of the QT interval.
    GeneReviews: Not available
    Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization.
    GeneReviews: Not available
    Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid.
    GeneReviews: Not available
    Menke-Hennekam syndrome 1
    MedGen: C5193034 OMIM: 618332 GeneReviews: Not available
    Compare labs
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    GeneReviews: Not available
    Rubinstein-Taybi syndrome 1
    MedGen: C4551859 OMIM: 180849 GeneReviews: Rubinstein-Taybi Syndrome
    Compare labs

    Copy number response

    Description
    Copy number response
    Haploinsufficency

    Sufficient evidence for dosage pathogenicity (Last evaluated 2019-10-23)

    ClinGen Genome Curation PagePubMed
    Triplosensitivity

    No evidence available (Last evaluated 2019-10-23)

    ClinGen Genome Curation PagePubMed

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Binding of HIV-1 Tat to p300 induces a conformational change in the CBP/p300 complex such that it can acquire and bind better to basal transcription factors, indicating Tat helps CBP/p300 recruit new partners to the transcription machinery PubMed
    tat HIV-1 Tat recruits the CBP/p300 complex, as well as other known cellular acetyltransferases, to the HIV-1 LTR promoter, an effect involved in the acetylation of histones H3 and H4, and HIV-1 transcriptional activation PubMed
    tat HIV-1 Tat binding peaks in Tat expression Jurkat cells are associated with specific cellular factors (CBP and ETS) and chromatin marks (H3K4me3 and H3K27me3) in Jurkat cells PubMed
    tat HIV-1 Tat treatment of hematopoietic progenitor cells upregulates CBP gene expression (7- to 9-fold) and protein levels (5- to 7-fold) within 6-12 hours after stimulation PubMed
    tat The N-terminal 24 amino acids of HIV-1 Tat mediate its binding to the KIX domain (amino acids 589-679) of CBP PubMed
    tat HIV-1 Tat regulates the activity of CBP by inhibiting CBP acetylation of histones, but not CBP acetylation of p53 or MyoD, indicating Tat induces a substrate selectivity for CBP PubMed
    tat HIV-1 Tat inhibits the histone acetyltransferase and transcriptional activation activities of CBP, an effect mediated by amino acids 86-101 of Tat PubMed
    tat HIV-1 Tat induces CBP to complex with NFkappaB p65 and bind to the IL-8 promoter leading to an upregulation of IL-8 expression PubMed
    tat Acetylation of the p50 subunit of NFkappaB by CBP/p300 is regulated by HIV-1 Tat PubMed
    tat HIV-1 Tat binds to the minimal histone acetyltransferase domain of the CBP/p300 complex (amino acids 1253-1710 of p300) and E1a binding domain (amino acids 1542-1710) of p300, an effect mediated by the basic domain (amino acids 48-57) of Tat PubMed
    tat Acetylation of HIV-1 Tat by the p300/CBP complex at Lys50 regulates Tat binding to cyclin T1 and HIV-1 TAR RNA, as well as Tat-mediated transactivation of the HIV-1 LTR promoter, by allowing Tat to dissociate from TAR RNA PubMed
    tat HIV-1 Tat is acetylated by the p300/CBP complex on Lys50 and Lys51 PubMed
    tat HIV-1 Tat induces the polyubiquitination and degradation of Tip60 through p300/CBP-associated E4-type ubiquitin-ligase activity, which results in a dramatic impairment of the Tip60-dependent apoptotic cell response to DNA damage PubMed
    Vpr vpr HIV-1 Vpr binds directly to the CBP co-activator to induce transcription of the HIV-1 LTR and glucocorticoid-responsive promoters PubMed
    integrase gag-pol Analysis of HIV-1 proviral integration sites in antiretroviral treatment patients indicates that CREBBP gene favors HIV-1 integration for expansion and persistence of infected cells, suggesting HIV-1 IN interacts with CREBBP PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables MRF binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables RNA polymerase II-specific DNA-binding transcription factor binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables acetyltransferase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    enables acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables chromatin DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables damaged DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables histone acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables histone acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables histone acetyltransferase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables p53 binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables peptide N-acetyltransferase activity TAS
    Traceable Author Statement
    more info
     
    enables peptide-lysine-N-acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transcription coactivator activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription coactivator activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables transcription coactivator binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription corepressor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in N-terminal peptidyl-lysine acetylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to UV IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in embryonic digit morphogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in histone acetylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in histone acetylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in histone glutamine methylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in homeostatic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription, DNA-templated ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of transforming growth factor beta receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein acetylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein acetylation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in protein destabilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein-containing complex assembly TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of cellular response to heat TAS
    Traceable Author Statement
    more info
     
    involved_in regulation of smoothened signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of transcription, DNA-templated TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in response to hypoxia TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in rhythmic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in signal transduction NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in stimulatory C-type lectin receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nuclear body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IC
    Inferred by Curator
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    CREB-binding protein
    Names
    histone lysine acetyltransferase CREBBP
    protein-lysine acetyltransferase CREBBP
    NP_001073315.1
    NP_004371.2
    XP_005255181.1
    XP_005255182.1
    XP_006720911.1
    XP_011520683.1
    XP_011520684.1
    XP_016878433.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_009873.2 RefSeqGene

      Range
      5001..160660
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_1426

    mRNA and Protein(s)

    1. NM_001079846.1NP_001073315.1  CREB-binding protein isoform b

      See identical proteins and their annotated locations for NP_001073315.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in a shorter protein (isoform b), compared to isoform a.
      Source sequence(s)
      AB210043, AC006111, U85962
      Consensus CDS
      CCDS45399.1
      UniProtKB/Swiss-Prot
      Q92793
      Related
      ENSP00000371502.3, ENST00000382070.7
      Conserved Domains (10) summary
      cd05495
      Location:10491156
      Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...
      smart00551
      Location:17281806
      ZnF_TAZ; TAZ zinc finger, present in p300 and CBP
      cd02337
      Location:16671707
      ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...
      pfam09606
      Location:19482375
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd15802
      Location:11681240
      RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases
      cd15557
      Location:12421273
      PHD_CBP_p300; PHD finger found in CREB-binding protein (CBP) and histone acetyltransferase p300
      pfam02135
      Location:363405
      zf-TAZ; TAZ zinc finger
      pfam02172
      Location:549629
      KIX; KIX domain
      pfam08214
      Location:13041611
      HAT_KAT11; Histone acetylation protein
      pfam09030
      Location:19962073
      Creb_binding; Creb binding
    2. NM_004380.3NP_004371.2  CREB-binding protein isoform a

      See identical proteins and their annotated locations for NP_004371.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform a).
      Source sequence(s)
      AB210043, AC006111, U85962
      Consensus CDS
      CCDS10509.1
      UniProtKB/Swiss-Prot
      Q92793
      Related
      ENSP00000262367.5, ENST00000262367.10
      Conserved Domains (10) summary
      cd05495
      Location:10871194
      Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...
      smart00551
      Location:17661844
      ZnF_TAZ; TAZ zinc finger, present in p300 and CBP
      cd02337
      Location:17051745
      ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...
      pfam09606
      Location:19862413
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd15802
      Location:12061278
      RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases
      cd15557
      Location:12801311
      PHD_CBP_p300; PHD finger found in CREB-binding protein (CBP) and histone acetyltransferase p300
      pfam02135
      Location:363430
      zf-TAZ; TAZ zinc finger
      pfam02172
      Location:587667
      KIX; KIX domain
      pfam08214
      Location:13421649
      HAT_KAT11; Histone acetylation protein
      pfam09030
      Location:20342111
      Creb_binding; Creb binding

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

      Range
      3725054..3880727 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005255124.4XP_005255181.1  CREB-binding protein isoform X2

      Conserved Domains (10) summary
      cd05495
      Location:10721179
      Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...
      smart00551
      Location:17511829
      ZnF_TAZ; TAZ zinc finger, present in p300 and CBP
      cd02337
      Location:16901730
      ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...
      pfam09606
      Location:19712398
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd15802
      Location:11911263
      RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases
      cd15557
      Location:12651296
      PHD_CBP_p300; PHD finger found in CREB-binding protein (CBP) and histone acetyltransferase p300
      pfam02135
      Location:363430
      zf-TAZ; TAZ zinc finger
      pfam02172
      Location:587667
      KIX; KIX domain
      pfam08214
      Location:13271634
      HAT_KAT11; Histone acetylation protein
      pfam09030
      Location:20192096
      Creb_binding; Creb binding
    2. XM_005255125.4XP_005255182.1  CREB-binding protein isoform X4

      Conserved Domains (10) summary
      cd05495
      Location:9481055
      Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...
      smart00551
      Location:16271705
      ZnF_TAZ; TAZ zinc finger, present in p300 and CBP
      cd02337
      Location:15661606
      ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...
      pfam09606
      Location:18212274
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd15802
      Location:10671139
      RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases
      cd15557
      Location:11411172
      PHD_CBP_p300; PHD finger found in CREB-binding protein (CBP) and histone acetyltransferase p300
      pfam02135
      Location:363430
      zf-TAZ; TAZ zinc finger
      pfam02172
      Location:587667
      KIX; KIX domain
      pfam08214
      Location:12031510
      HAT_KAT11; Histone acetylation protein
      pfam09030
      Location:18951972
      Creb_binding; Creb binding
    3. XM_017022944.1XP_016878433.1  CREB-binding protein isoform X1

    4. XM_006720848.3XP_006720911.1  CREB-binding protein isoform X3

      Conserved Domains (10) summary
      cd05495
      Location:10871194
      Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...
      smart00551
      Location:16791757
      ZnF_TAZ; TAZ zinc finger, present in p300 and CBP
      cd02337
      Location:16181658
      ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...
      pfam09606
      Location:18992326
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd15802
      Location:12061278
      RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases
      cd15557
      Location:12801311
      PHD_CBP_p300; PHD finger found in CREB-binding protein (CBP) and histone acetyltransferase p300
      pfam02135
      Location:363430
      zf-TAZ; TAZ zinc finger
      pfam02172
      Location:587667
      KIX; KIX domain
      pfam09030
      Location:19472024
      Creb_binding; Creb binding
      cl02120
      Location:13421562
      HAT_KAT11; Histone acetylation protein
    5. XM_011522381.2XP_011520683.1  CREB-binding protein isoform X5

      Conserved Domains (10) summary
      cd05495
      Location:836943
      Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...
      smart00551
      Location:15151593
      ZnF_TAZ; TAZ zinc finger, present in p300 and CBP
      cd02337
      Location:14541494
      ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...
      pfam09606
      Location:17352162
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd15802
      Location:9551027
      RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases
      cd15557
      Location:10291060
      PHD_CBP_p300; PHD finger found in CREB-binding protein (CBP) and histone acetyltransferase p300
      pfam02135
      Location:112179
      zf-TAZ; TAZ zinc finger
      pfam02172
      Location:336416
      KIX; KIX domain
      pfam08214
      Location:10911398
      HAT_KAT11; Histone acetylation protein
      pfam09030
      Location:17831860
      Creb_binding; Creb binding
    6. XM_011522382.3XP_011520684.1  CREB-binding protein isoform X6

      Conserved Domains (4) summary
      cd05495
      Location:10871194
      Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...
      cd15802
      Location:12061278
      RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases
      pfam02135
      Location:363430
      zf-TAZ; TAZ zinc finger
      pfam02172
      Location:587667
      KIX; KIX domain
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