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    Eps8 epidermal growth factor receptor pathway substrate 8 [ Mus musculus (house mouse) ]

    Gene ID: 13860, updated on 5-Sep-2021

    Summary

    Official Symbol
    Eps8provided by MGI
    Official Full Name
    epidermal growth factor receptor pathway substrate 8provided by MGI
    Primary source
    MGI:MGI:104684
    See related
    Ensembl:ENSMUSG00000015766
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AW261790
    Expression
    Broad expression in colon adult (RPKM 16.0), large intestine adult (RPKM 15.7) and 23 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Eps8 in Genome Data Viewer
    Location:
    6 G1; 6 66.78 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (137454243..137626395, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (137477245..137649397, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (137425766..137597641, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene RAS-like, estrogen-regulated, growth-inhibitor Neighboring gene predicted gene, 38914 Neighboring gene predicted gene, 52924 Neighboring gene protein tyrosine phosphatase, receptor type, O Neighboring gene predicted gene, 38915 Neighboring gene serine/threonine kinase receptor associated protein

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables actin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling adaptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables small GTPase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in Rac protein signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in Rho protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in actin crosslink formation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in actin crosslink formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within actin cytoskeleton reorganization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in actin filament bundle assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within actin filament bundle assembly IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in actin filament bundle assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in actin polymerization-dependent cell motility IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within adult locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in barbed-end actin filament capping IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in barbed-end actin filament capping IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within behavioral response to ethanol IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in dendritic cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in exit from mitosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of ruffle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of Rho protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of actin filament length IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cell shape IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of postsynaptic membrane neurotransmitter receptor levels EXP
    Inferred from Experiment
    more info
    PubMed 
    involved_in regulation of postsynaptic membrane neurotransmitter receptor levels IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of postsynaptic membrane neurotransmitter receptor levels IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of NMDA selective glutamate receptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in brush border IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    is_active_in glutamatergic synapse EXP
    Inferred from Experiment
    more info
    PubMed 
    located_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuron projection IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in ruffle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in ruffle membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in stereocilium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in stereocilium bundle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in stereocilium tip IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    epidermal growth factor receptor kinase substrate 8

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271587.1NP_001258516.1  epidermal growth factor receptor kinase substrate 8 isoform 2

      See identical proteins and their annotated locations for NP_001258516.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains a distinct 5' UTR and initiates translation at an alternate start codon, compared to variant 1. The resulting isoform (2) has a distinct N-terminus and is longer than isoform 1.
      Source sequence(s)
      AC166347, AK149683, AK166156, BY209758
      UniProtKB/Swiss-Prot
      Q08509
      UniProtKB/TrEMBL
      Q3U2Z5
      Conserved Domains (3) summary
      cd09540
      Location:745809
      SAM_EPS8-like; SAM domain of EPS8-like subfamily
      cd11764
      Location:560613
      SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
      cd01210
      Location:90217
      PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain
    2. NM_001271588.1NP_001258517.1  epidermal growth factor receptor kinase substrate 8 isoform 1

      See identical proteins and their annotated locations for NP_001258517.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same isoform (1).
      Source sequence(s)
      AC093120, AC166347
      Consensus CDS
      CCDS20665.1
      UniProtKB/Swiss-Prot
      Q08509
      Related
      ENSMUSP00000107509.2, ENSMUST00000111878.8
      Conserved Domains (3) summary
      cd09540
      Location:719783
      SAM_EPS8-like; SAM domain of EPS8-like subfamily
      cd11764
      Location:534587
      SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
      cd01210
      Location:64191
      PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain
    3. NM_001271589.1NP_001258518.1  epidermal growth factor receptor kinase substrate 8 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) contains a distinct 5' UTR, initiates translation at a downstream start codon and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting isoform (3) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC093120, AK166156, BB854890
      UniProtKB/Swiss-Prot
      Q08509
      Conserved Domains (2) summary
      cd09540
      Location:459523
      SAM_EPS8-like; SAM domain of EPS8-like subfamily
      cd11764
      Location:274327
      SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    4. NM_001271595.1NP_001258524.1  epidermal growth factor receptor kinase substrate 8 isoform 1

      See identical proteins and their annotated locations for NP_001258524.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same isoform (1).
      Source sequence(s)
      AC166347, AK148424, AK149683, AK166156
      Consensus CDS
      CCDS20665.1
      UniProtKB/Swiss-Prot
      Q08509
      UniProtKB/TrEMBL
      Q3UFL4
      Related
      ENSMUSP00000098402.3, ENSMUST00000100841.9
      Conserved Domains (3) summary
      cd09540
      Location:719783
      SAM_EPS8-like; SAM domain of EPS8-like subfamily
      cd11764
      Location:534587
      SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
      cd01210
      Location:64191
      PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain
    5. NM_007945.3NP_031971.2  epidermal growth factor receptor kinase substrate 8 isoform 1

      See identical proteins and their annotated locations for NP_031971.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1. Variants 1, 2 and 3 encode the same isoform (1).
      Source sequence(s)
      AC166347, AK166156
      Consensus CDS
      CCDS20665.1
      UniProtKB/Swiss-Prot
      Q08509
      Related
      ENSMUSP00000052776.7, ENSMUST00000058210.13
      Conserved Domains (3) summary
      cd09540
      Location:719783
      SAM_EPS8-like; SAM domain of EPS8-like subfamily
      cd11764
      Location:534587
      SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
      cd01210
      Location:64191
      PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      137454243..137626395 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006505508.3XP_006505571.1  epidermal growth factor receptor kinase substrate 8 isoform X2

      Conserved Domains (3) summary
      cd09540
      Location:689753
      SAM_EPS8-like; SAM domain of EPS8-like subfamily
      cd11764
      Location:504557
      SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
      cd01210
      Location:34161
      PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain
    2. XM_030255145.1XP_030111005.1  epidermal growth factor receptor kinase substrate 8 isoform X1

      Conserved Domains (3) summary
      cd09540
      Location:719783
      SAM_EPS8-like; SAM domain of EPS8-like subfamily
      cd11764
      Location:534587
      SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
      cd01210
      Location:64191
      PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain
    3. XM_011241204.2XP_011239506.1  epidermal growth factor receptor kinase substrate 8 isoform X1

      See identical proteins and their annotated locations for XP_011239506.1

      UniProtKB/Swiss-Prot
      Q08509
      Conserved Domains (3) summary
      cd09540
      Location:719783
      SAM_EPS8-like; SAM domain of EPS8-like subfamily
      cd11764
      Location:534587
      SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
      cd01210
      Location:64191
      PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain
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