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    Eps15l1 epidermal growth factor receptor pathway substrate 15-like 1 [ Mus musculus (house mouse) ]

    Gene ID: 13859, updated on 23-Jun-2021

    Summary

    Official Symbol
    Eps15l1provided by MGI
    Official Full Name
    epidermal growth factor receptor pathway substrate 15-like 1provided by MGI
    Primary source
    MGI:MGI:104582
    See related
    Ensembl:ENSMUSG00000006276
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Eps; Eps1; Eps15R; AI593686; Eps15-rs; 9830147J04Rik
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 13.8), CNS E14 (RPKM 12.2) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Eps15l1 in Genome Data Viewer
    Location:
    8; 8 B3.3
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (73094834..73175410, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (72340990..72421576, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (74864894..74945373, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene high mobility group nucleosomal binding domain 2, pseudogene Neighboring gene Kruppel-like factor 2 (lung) Neighboring gene predicted gene, 46043 Neighboring gene calreticulin 3 Neighboring gene RIKEN cDNA 1700030K09 gene Neighboring gene calcium homeostasis endoplasmic reticulum protein

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in endosomal transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of clathrin coat of coated pit IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of clathrin coat of coated pit IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in clathrin-coated pit IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    epidermal growth factor receptor substrate 15-like 1
    Names
    epidermal growth factor receptor pathway substrate 15-related sequence
    eps15-related protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001122832.1NP_001116304.1  epidermal growth factor receptor substrate 15-like 1 isoform b

      See identical proteins and their annotated locations for NP_001116304.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks several 3' exons compared to variant 1, and its 3' terminal exon extends past a splice site that is used in variant 1. The resulting isoform (b) is shorter and has a distinct C-terminus compared to isoform a.
      Source sequence(s)
      AA217470, AK036728, BY270130
      Consensus CDS
      CCDS85560.1
      UniProtKB/Swiss-Prot
      Q60902
      UniProtKB/TrEMBL
      A0A1D5RLS1
      Related
      ENSMUSP00000148484.2, ENSMUST00000212590.2
      Conserved Domains (4) summary
      smart00027
      Location:266362
      EH; Eps15 homology domain
      cd00052
      Location:131196
      EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
      pfam07926
      Location:396523
      TPR_MLP1_2; TPR/MLP1/MLP2-like protein
      cl23720
      Location:400517
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    2. NM_001289859.1NP_001276788.1  epidermal growth factor receptor substrate 15-like 1 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site and lacks two consecutive exons in the 3' coding region, compared to variant 1. It encodes isoform c, which is shorter than isoform a.
      Source sequence(s)
      AK146781, AK152602, BB855263, CD774936
      Consensus CDS
      CCDS85561.1
      UniProtKB/Swiss-Prot
      Q60902
      Related
      ENSMUSP00000148468.2, ENSMUST00000212121.2
      Conserved Domains (4) summary
      smart00027
      Location:266362
      EH; Eps15 homology domain
      cd00052
      Location:131196
      EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
      pfam07926
      Location:396523
      TPR_MLP1_2; TPR/MLP1/MLP2-like protein
      cl23720
      Location:400517
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    3. NM_007944.3NP_031970.2  epidermal growth factor receptor substrate 15-like 1 isoform a

      See identical proteins and their annotated locations for NP_031970.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AK146781, BY270130, CD774936
      Consensus CDS
      CCDS52597.1
      UniProtKB/Swiss-Prot
      Q60902
      Related
      ENSMUSP00000129739.2, ENSMUST00000163643.3
      Conserved Domains (4) summary
      smart00027
      Location:266362
      EH; Eps15 homology domain
      cd00052
      Location:131196
      EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
      pfam07926
      Location:396523
      TPR_MLP1_2; TPR/MLP1/MLP2-like protein
      cl02488
      Location:383564
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      73094834..73175410 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017312560.3XP_017168049.1  epidermal growth factor receptor substrate 15-like 1 isoform X6

      Conserved Domains (3) summary
      smart00027
      Location:266362
      EH; Eps15 homology domain
      COG1196
      Location:383565
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cl27812
      Location:13103
      EF-hand_4; Cytoskeletal-regulatory complex EF hand
    2. XM_006509550.4XP_006509613.1  epidermal growth factor receptor substrate 15-like 1 isoform X7

      Conserved Domains (2) summary
      COG1196
      Location:97278
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cl27812
      Location:3076
      EF-hand_4; Cytoskeletal-regulatory complex EF hand
    3. XM_006509548.5XP_006509611.1  epidermal growth factor receptor substrate 15-like 1 isoform X5

      Conserved Domains (3) summary
      smart00027
      Location:266362
      EH; Eps15 homology domain
      COG1196
      Location:383564
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cl27812
      Location:13103
      EF-hand_4; Cytoskeletal-regulatory complex EF hand
    4. XM_006509547.5XP_006509610.1  epidermal growth factor receptor substrate 15-like 1 isoform X4

      Conserved Domains (3) summary
      smart00027
      Location:266362
      EH; Eps15 homology domain
      COG1196
      Location:383564
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cl27812
      Location:13103
      EF-hand_4; Cytoskeletal-regulatory complex EF hand
    5. XM_006509544.5XP_006509607.1  epidermal growth factor receptor substrate 15-like 1 isoform X1

      Conserved Domains (3) summary
      smart00027
      Location:266362
      EH; Eps15 homology domain
      COG1196
      Location:383564
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cl27812
      Location:13103
      EF-hand_4; Cytoskeletal-regulatory complex EF hand
    6. XM_006509546.5XP_006509609.1  epidermal growth factor receptor substrate 15-like 1 isoform X3

      Conserved Domains (3) summary
      smart00027
      Location:266362
      EH; Eps15 homology domain
      COG1196
      Location:383565
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cl27812
      Location:13103
      EF-hand_4; Cytoskeletal-regulatory complex EF hand
    7. XM_006509545.5XP_006509608.1  epidermal growth factor receptor substrate 15-like 1 isoform X2

      Conserved Domains (3) summary
      smart00027
      Location:266362
      EH; Eps15 homology domain
      COG1196
      Location:383565
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cl27812
      Location:13103
      EF-hand_4; Cytoskeletal-regulatory complex EF hand

    RNA

    1. XR_004934761.1 RNA Sequence

    2. XR_379029.5 RNA Sequence

    3. XR_379032.5 RNA Sequence

    4. XR_001778398.3 RNA Sequence

    5. XR_003947228.2 RNA Sequence

    6. XR_379030.5 RNA Sequence

    7. XR_004934766.1 RNA Sequence

    8. XR_004934765.1 RNA Sequence

    9. XR_004934767.1 RNA Sequence

    10. XR_004934763.1 RNA Sequence

    11. XR_001778400.3 RNA Sequence

    12. XR_004934764.1 RNA Sequence

    13. XR_003947230.2 RNA Sequence

    14. XR_379031.5 RNA Sequence

      Related
      ENSMUST00000212950.2
    15. XR_004934762.1 RNA Sequence

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