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    Epn2 epsin 2 [ Mus musculus (house mouse) ]

    Gene ID: 13855, updated on 26-Sep-2022

    Summary

    Official Symbol
    Epn2provided by MGI
    Official Full Name
    epsin 2provided by MGI
    Primary source
    MGI:MGI:1333766
    See related
    Ensembl:ENSMUSG00000001036 AllianceGenome:MGI:1333766
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ibp2; 9530051D10Rik
    Summary
    Predicted to enable clathrin binding activity and phospholipid binding activity. Acts upstream of or within Notch signaling pathway; embryonic organ development; and in utero embryonic development. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be part of clathrin coat of endocytic vesicle. Predicted to be active in endosome and plasma membrane. Orthologous to human EPN2 (epsin 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in lung adult (RPKM 26.3), cerebellum adult (RPKM 19.7) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Epn2 in Genome Data Viewer
    Location:
    11; 11 B2
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (61406709..61470560, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (61515883..61579717, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase 7 Neighboring gene B9 protein domain 1, opposite strand Neighboring gene B9 protein domain 1 Neighboring gene GRB2-related adaptor protein Neighboring gene solute carrier family 5 (sodium/glucose cotransporter), member 10 Neighboring gene family with sequence similarity 83, member G

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables clathrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of clathrin coat of endocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    part_of clathrin vesicle coat IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    epsin-2
    Names
    EPS-15-interacting protein 2
    intersectin-EH-binding protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252188.2NP_001239117.1  epsin-2 isoform 1

      See identical proteins and their annotated locations for NP_001239117.1

      Status: VALIDATED

      Source sequence(s)
      AK139234, AK160782, AL604029
      Consensus CDS
      CCDS56780.1
      UniProtKB/TrEMBL
      A0A8C6HPE0, J3QNT7, Q5NCM7
      Related
      ENSMUSP00000136950.2, ENSMUST00000179936.8
      Conserved Domains (1) summary
      cd16990
      Location:19141
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
    2. NM_001252189.2NP_001239118.1  epsin-2 isoform 3

      See identical proteins and their annotated locations for NP_001239118.1

      Status: VALIDATED

      Source sequence(s)
      AK160782, AL604029
      Consensus CDS
      CCDS56779.1
      UniProtKB/Swiss-Prot
      Q8CHU3
      UniProtKB/TrEMBL
      A0A8C6HQQ2, Q5NCM7
      Related
      ENSMUSP00000104353.2, ENSMUST00000108713.8
      Conserved Domains (1) summary
      cd16990
      Location:19141
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
    3. NM_001362585.1NP_001349514.1  epsin-2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL604029
      Conserved Domains (1) summary
      cd16990
      Location:19141
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
    4. NM_001362586.1NP_001349515.1  epsin-2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL604029
      Conserved Domains (1) summary
      cd16990
      Location:19141
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
    5. NM_001362587.1NP_001349516.1  epsin-2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL604029
      Consensus CDS
      CCDS24816.1
      UniProtKB/Swiss-Prot
      Q8BZ85
      UniProtKB/TrEMBL
      A0A8C6HQR8
      Conserved Domains (1) summary
      cd16990
      Location:19141
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
    6. NM_010148.4NP_034278.1  epsin-2 isoform 2

      See identical proteins and their annotated locations for NP_034278.1

      Status: VALIDATED

      Source sequence(s)
      AK160782, AL604029, CX123717
      Consensus CDS
      CCDS24816.1
      UniProtKB/Swiss-Prot
      Q8BZ85, Q8CHU3
      UniProtKB/TrEMBL
      A0A8C6HQR8, Q5NCM7
      Related
      ENSMUSP00000001063.9, ENSMUST00000001063.15
      Conserved Domains (1) summary
      cd16990
      Location:19141
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      61406709..61470560 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006532165.5XP_006532228.1  epsin-2 isoform X1

      See identical proteins and their annotated locations for XP_006532228.1

      Conserved Domains (1) summary
      cd16990
      Location:19141
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
    2. XM_036156313.1XP_036012206.1  epsin-2 isoform X6

    3. XM_036156312.1XP_036012205.1  epsin-2 isoform X5

    4. XM_030245537.2XP_030101397.1  epsin-2 isoform X4

      UniProtKB/TrEMBL
      A0A8C6HQQ2, Q5NCM7
      Conserved Domains (1) summary
      cd16990
      Location:19141
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
    5. XM_030245533.2XP_030101393.1  epsin-2 isoform X3

      UniProtKB/Swiss-Prot
      Q8BZ85
      UniProtKB/TrEMBL
      A0A8C6HQR8
      Related
      ENSMUSP00000136553.2, ENSMUST00000178202.8
      Conserved Domains (1) summary
      cd16990
      Location:19141
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
    6. XM_006532171.5XP_006532234.1  epsin-2 isoform X2

      See identical proteins and their annotated locations for XP_006532234.1

      UniProtKB/TrEMBL
      A0A8C6HPE0, J3QNT7
      Related
      ENSMUSP00000104352.2, ENSMUST00000108712.8
      Conserved Domains (1) summary
      cd16990
      Location:19141
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
    7. XM_030245539.2XP_030101399.1  epsin-2 isoform X4

      UniProtKB/TrEMBL
      A0A8C6HQQ2, Q5NCM7
      Conserved Domains (1) summary
      cd16990
      Location:19141
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
    8. XM_036156302.1XP_036012195.1  epsin-2 isoform X2

      UniProtKB/TrEMBL
      A0A8C6HPE0, J3QNT7
      Conserved Domains (1) summary
      cd16990
      Location:19141
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
    9. XM_030245538.2XP_030101398.1  epsin-2 isoform X4

      UniProtKB/TrEMBL
      A0A8C6HQQ2, Q5NCM7
      Conserved Domains (1) summary
      cd16990
      Location:19141
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
    10. XM_006532166.5XP_006532229.1  epsin-2 isoform X1

      See identical proteins and their annotated locations for XP_006532229.1

      Conserved Domains (1) summary
      cd16990
      Location:19141
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
    11. XM_006532168.5XP_006532231.1  epsin-2 isoform X1

      See identical proteins and their annotated locations for XP_006532231.1

      Conserved Domains (1) summary
      cd16990
      Location:19141
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
    12. XM_036156307.1XP_036012200.1  epsin-2 isoform X4

      UniProtKB/TrEMBL
      A0A8C6HQQ2, Q5NCM7
      Conserved Domains (1) summary
      cd16990
      Location:19141
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
    13. XM_030245531.2XP_030101391.1  epsin-2 isoform X3

      UniProtKB/Swiss-Prot
      Q8BZ85
      UniProtKB/TrEMBL
      A0A8C6HQR8
      Conserved Domains (1) summary
      cd16990
      Location:19141
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
    14. XM_030245528.2XP_030101388.1  epsin-2 isoform X2

      UniProtKB/TrEMBL
      A0A8C6HPE0, J3QNT7
      Conserved Domains (1) summary
      cd16990
      Location:19141
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
    15. XM_011248711.4XP_011247013.1  epsin-2 isoform X1

      See identical proteins and their annotated locations for XP_011247013.1

      Conserved Domains (1) summary
      cd16990
      Location:19141
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
    16. XM_036156305.1XP_036012198.1  epsin-2 isoform X4

      UniProtKB/TrEMBL
      A0A8C6HQQ2, Q5NCM7
      Conserved Domains (1) summary
      cd16990
      Location:19141
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
    17. XM_036156303.1XP_036012196.1  epsin-2 isoform X3

      UniProtKB/Swiss-Prot
      Q8BZ85
      UniProtKB/TrEMBL
      A0A8C6HQR8
      Conserved Domains (1) summary
      cd16990
      Location:19141
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
    18. XM_006532167.5XP_006532230.1  epsin-2 isoform X1

      See identical proteins and their annotated locations for XP_006532230.1

      Conserved Domains (1) summary
      cd16990
      Location:19141
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
    19. XM_036156308.1XP_036012201.1  epsin-2 isoform X4

      UniProtKB/TrEMBL
      A0A8C6HQQ2, Q5NCM7
      Conserved Domains (1) summary
      cd16990
      Location:19141
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
    20. XM_036156296.1XP_036012189.1  epsin-2 isoform X1

      Conserved Domains (1) summary
      cd16990
      Location:19141
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
    21. XM_036156292.1XP_036012185.1  epsin-2 isoform X1

      Conserved Domains (1) summary
      cd16990
      Location:19141
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
    22. XM_036156306.1XP_036012199.1  epsin-2 isoform X4

      UniProtKB/TrEMBL
      A0A8C6HQQ2, Q5NCM7
      Conserved Domains (1) summary
      cd16990
      Location:19141
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
    23. XM_036156299.1XP_036012192.1  epsin-2 isoform X2

      UniProtKB/TrEMBL
      A0A8C6HPE0, J3QNT7
      Conserved Domains (1) summary
      cd16990
      Location:19141
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
    24. XM_036156291.1XP_036012184.1  epsin-2 isoform X1

      Conserved Domains (1) summary
      cd16990
      Location:19141
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
    25. XM_036156309.1XP_036012202.1  epsin-2 isoform X4

      UniProtKB/TrEMBL
      A0A8C6HQQ2, Q5NCM7
      Related
      ENSMUSP00000104351.2, ENSMUST00000108711.8
      Conserved Domains (1) summary
      cd16990
      Location:19141
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
    26. XM_030245534.2XP_030101394.1  epsin-2 isoform X3

      UniProtKB/Swiss-Prot
      Q8BZ85
      UniProtKB/TrEMBL
      A0A8C6HQR8
      Conserved Domains (1) summary
      cd16990
      Location:19141
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
    27. XM_036156301.1XP_036012194.1  epsin-2 isoform X2

      UniProtKB/TrEMBL
      A0A8C6HPE0, J3QNT7
      Conserved Domains (1) summary
      cd16990
      Location:19141
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
    28. XM_006532170.5XP_006532233.1  epsin-2 isoform X1

      See identical proteins and their annotated locations for XP_006532233.1

      Conserved Domains (1) summary
      cd16990
      Location:19141
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
    29. XM_036156297.1XP_036012190.1  epsin-2 isoform X1

      Conserved Domains (1) summary
      cd16990
      Location:19141
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
    30. XM_036156311.1XP_036012204.1  epsin-2 isoform X4

      UniProtKB/TrEMBL
      A0A8C6HQQ2, Q5NCM7
      Conserved Domains (1) summary
      cd16990
      Location:19141
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
    31. XM_036156300.1XP_036012193.1  epsin-2 isoform X2

      UniProtKB/TrEMBL
      A0A8C6HPE0, J3QNT7
      Conserved Domains (1) summary
      cd16990
      Location:19141
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
    32. XM_036156295.1XP_036012188.1  epsin-2 isoform X1

      Conserved Domains (1) summary
      cd16990
      Location:19141
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
    33. XM_036156310.1XP_036012203.1  epsin-2 isoform X4

      UniProtKB/TrEMBL
      A0A8C6HQQ2, Q5NCM7
      Conserved Domains (1) summary
      cd16990
      Location:19141
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
    34. XM_036156293.1XP_036012186.1  epsin-2 isoform X1

      Conserved Domains (1) summary
      cd16990
      Location:19141
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
    35. XM_030245540.2XP_030101400.1  epsin-2 isoform X4

      UniProtKB/TrEMBL
      A0A8C6HQQ2, Q5NCM7
      Conserved Domains (1) summary
      cd16990
      Location:19141
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
    36. XM_030245535.2XP_030101395.1  epsin-2 isoform X3

      UniProtKB/Swiss-Prot
      Q8BZ85
      UniProtKB/TrEMBL
      A0A8C6HQR8
      Conserved Domains (1) summary
      cd16990
      Location:19141
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
    37. XM_006532169.5XP_006532232.1  epsin-2 isoform X1

      See identical proteins and their annotated locations for XP_006532232.1

      Conserved Domains (1) summary
      cd16990
      Location:19141
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
    38. XM_036156294.1XP_036012187.1  epsin-2 isoform X1

      Conserved Domains (1) summary
      cd16990
      Location:19141
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
    39. XM_036156304.1XP_036012197.1  epsin-2 isoform X3

      UniProtKB/Swiss-Prot
      Q8BZ85
      UniProtKB/TrEMBL
      A0A8C6HQR8
      Conserved Domains (1) summary
      cd16990
      Location:19141
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
    40. XM_030245530.2XP_030101390.1  epsin-2 isoform X2

      UniProtKB/TrEMBL
      A0A8C6HPE0, J3QNT7
      Conserved Domains (1) summary
      cd16990
      Location:19141
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
    41. XM_011248713.4XP_011247015.1  epsin-2 isoform X1

      See identical proteins and their annotated locations for XP_011247015.1

      Conserved Domains (1) summary
      cd16990
      Location:19141
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
    42. XM_030245541.2XP_030101401.1  epsin-2 isoform X4

      UniProtKB/TrEMBL
      A0A8C6HQQ2, Q5NCM7
      Conserved Domains (1) summary
      cd16990
      Location:19141
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
    43. XM_030245532.2XP_030101392.1  epsin-2 isoform X3

      UniProtKB/Swiss-Prot
      Q8BZ85
      UniProtKB/TrEMBL
      A0A8C6HQR8
      Conserved Domains (1) summary
      cd16990
      Location:19141
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
    44. XM_030245536.1XP_030101396.1  epsin-2 isoform X4

      UniProtKB/TrEMBL
      A0A8C6HQQ2, Q5NCM7
      Conserved Domains (1) summary
      cd16990
      Location:19141
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family