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    Ephb4 Eph receptor B4 [ Mus musculus (house mouse) ]

    Gene ID: 13846, updated on 12-Sep-2021

    Summary

    Official Symbol
    Ephb4provided by MGI
    Official Full Name
    Eph receptor B4provided by MGI
    Primary source
    MGI:MGI:104757
    See related
    Ensembl:ENSMUSG00000029710
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Htk; MDK2; Myk1; Tyro; Tyro11; AI042935; b2b2412C; b2b2412Clo
    Expression
    Broad expression in lung adult (RPKM 50.3), limb E14.5 (RPKM 38.3) and 24 other tissues See more
    Orthologs
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    Genomic context

    See Ephb4 in Genome Data Viewer
    Location:
    5; 5 G2
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (137348371..137372784)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (137350109..137374522)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (137791337..137815750)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 12 (potassium/chloride transporters), member 9 Neighboring gene predicted gene, 52791 Neighboring gene zonadhesin Neighboring gene ribosomal protein L36, pseudogene 9 Neighboring gene predicted gene, 38725

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Chemically induced (ENU) (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ephrin receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transmembrane receptor protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables transmembrane receptor protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transmembrane-ephrin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell migration involved in sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ephrin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in ephrin receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in ephrin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in heart morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in multicellular organism development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of T cell costimulation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of aorta morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in transmembrane receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within venous blood vessel morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in integral component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    ephrin type-B receptor 4
    Names
    developmental kinase 2
    hepatoma transmembrane kinase
    mDK-2
    tyrosine kinase MYK-1
    NP_001153043.1
    NP_034274.4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159571.1NP_001153043.1  ephrin type-B receptor 4 isoform a precursor

      See identical proteins and their annotated locations for NP_001153043.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AK046884, AK049340, BB677774
      Consensus CDS
      CCDS51671.1
      UniProtKB/TrEMBL
      Q8C7S3, Q8C8K1
      Related
      ENSMUSP00000106684.3, ENSMUST00000111055.9
      Conserved Domains (7) summary
      cd05065
      Location:619887
      PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
      cd09554
      Location:916982
      SAM_EPH-B4; SAM domain of EPH-B4 subfamily of tyrosine kinase receptors
      smart00454
      Location:913980
      SAM; Sterile alpha motif
      cd10474
      Location:17196
      EphR_LBD_B4; Ligand Binding Domain of Ephrin type-B Receptor 4
      cd00063
      Location:443535
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07714
      Location:624883
      Pkinase_Tyr; Protein tyrosine kinase
      pfam14575
      Location:571619
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
    2. NM_010144.6NP_034274.4  ephrin type-B receptor 4 isoform b precursor

      See identical proteins and their annotated locations for NP_034274.4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. This results in a shorter protein (isoform b) compared to isoform a.
      Source sequence(s)
      AK049340, AK132392, BB677774, BC090839
      Consensus CDS
      CCDS19767.1
      UniProtKB/Swiss-Prot
      P54761
      UniProtKB/TrEMBL
      Q3V1K8, Q8C7S3
      Related
      ENSMUSP00000051622.9, ENSMUST00000061244.15
      Conserved Domains (7) summary
      cd05065
      Location:610878
      PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
      cd09554
      Location:907973
      SAM_EPH-B4; SAM domain of EPH-B4 subfamily of tyrosine kinase receptors
      smart00454
      Location:904971
      SAM; Sterile alpha motif
      cd10474
      Location:17196
      EphR_LBD_B4; Ligand Binding Domain of Ephrin type-B Receptor 4
      cd00063
      Location:434526
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07714
      Location:615874
      Pkinase_Tyr; Protein tyrosine kinase
      pfam14575
      Location:562610
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      137348371..137372784
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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