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    Epc1 enhancer of polycomb homolog 1 [ Mus musculus (house mouse) ]

    Gene ID: 13831, updated on 2-Oct-2018

    Summary

    Official Symbol
    Epc1provided by MGI
    Official Full Name
    enhancer of polycomb homolog 1provided by MGI
    Primary source
    MGI:MGI:1278322
    See related
    Ensembl:ENSMUSG00000024240 Vega:OTTMUSG00000017262
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mir-1893; 2400007E14Rik; 5730566F07Rik; A930032N02Rik
    Expression
    Ubiquitous expression in CNS E14 (RPKM 19.2), whole brain E14.5 (RPKM 18.8) and 28 other tissues See more
    Orthologs

    Genomic context

    See Epc1 in Genome Data Viewer
    Location:
    18; 18 A1
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 18 NC_000084.6 (6435951..6516108, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (6435949..6516085, complement)

    Chromosome 18 - NC_000084.6Genomic Context describing neighboring genes Neighboring gene ribosomal protein L27, pseudogene 3 Neighboring gene prothymosin alpha pseudogene Neighboring gene microRNA 1893 Neighboring gene charged multivesicular body protein 3 pseudogene Neighboring gene RIKEN cDNA 4921524L21 gene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to histone acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    contributes_to histone acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    chromatin organization IEA
    Inferred from Electronic Annotation
    more info
     
    histone H2A acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    histone H4 acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of gene expression, epigenetic ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of striated muscle cell differentiation ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of growth IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    NuA4 histone acetyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
     
    Piccolo NuA4 histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Piccolo NuA4 histone acetyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    enhancer of polycomb homolog 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001276350.1NP_001263279.1  enhancer of polycomb homolog 1 isoform 3

      See identical proteins and their annotated locations for NP_001263279.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks several exons in the central and 3' coding regions and includes an alternate 3' terminal exon, resulting in a novel 3' coding region and 3' UTR, compared to variant 2. It encodes isoform 3 which is shorter and has a distinct C-terminus, compared to isoform 2.
      Source sequence(s)
      AC139300, AK040254, AV356347, BB343428, BC038636, BC055805
      Consensus CDS
      CCDS70868.1
      UniProtKB/Swiss-Prot
      Q8C9X6
      UniProtKB/TrEMBL
      Q6PBH3, Q7TNR8
      Related
      ENSMUSP00000060599.5, OTTMUSP00000018780, ENSMUST00000050542.5, OTTMUST00000041774
      Conserved Domains (1) summary
      pfam10513
      Location:651
      EPL1; Enhancer of polycomb-like
    2. NM_007935.2NP_031961.1  enhancer of polycomb homolog 1 isoform 1

      See identical proteins and their annotated locations for NP_031961.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR and in the 5' coding region, compared to variant 2. It encodes isoform 1 which is shorter and has a distinct N-terminus, compared to isoform 2.
      Source sequence(s)
      AI849475, AK148194, AK149317, BB207261, BM936825, DV652878
      Consensus CDS
      CCDS37726.1
      UniProtKB/Swiss-Prot
      Q8C9X6
      UniProtKB/TrEMBL
      Q3UEV1, Q3UG01
      Related
      ENSMUSP00000111536.2, OTTMUSP00000018779, ENSMUST00000115870.8, OTTMUST00000041773
      Conserved Domains (2) summary
      pfam06752
      Location:572763
      E_Pc_C; Enhancer of Polycomb C-terminus
      pfam10513
      Location:198
      EPL1; Enhancer of polycomb-like
    3. NM_027497.3NP_081773.1  enhancer of polycomb homolog 1 isoform 2

      See identical proteins and their annotated locations for NP_081773.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents the longest transcript and encodes the longest isoform (2).
      Source sequence(s)
      AC139300, AF079765, AK040254
      Consensus CDS
      CCDS29041.1
      UniProtKB/Swiss-Prot
      Q8C9X6
      Related
      ENSMUSP00000028100.6, OTTMUSP00000018778, ENSMUST00000028100.12, OTTMUST00000041772
      Conserved Domains (2) summary
      pfam06752
      Location:622813
      E_Pc_C; Enhancer of Polycomb C-terminus
      pfam10513
      Location:7148
      EPL1; Enhancer of polycomb-like

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000084.6 Reference GRCm38.p4 C57BL/6J

      Range
      6435951..6516108 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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