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    Epc1 enhancer of polycomb homolog 1 [ Mus musculus (house mouse) ]

    Gene ID: 13831, updated on 26-Sep-2022

    Summary

    Official Symbol
    Epc1provided by MGI
    Official Full Name
    enhancer of polycomb homolog 1provided by MGI
    Primary source
    MGI:MGI:1278322
    See related
    Ensembl:ENSMUSG00000024240 AllianceGenome:MGI:1278322
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mir-1893; 2400007E14Rik; 5730566F07Rik; A930032N02Rik
    Summary
    Predicted to contribute to histone acetyltransferase activity. Predicted to be involved in histone acetylation and regulation of transcription, DNA-templated. Predicted to act upstream of or within negative regulation of gene expression, epigenetic; positive regulation of striated muscle cell differentiation; and regulation of transcription by RNA polymerase II. Predicted to be located in nuclear membrane and nucleoplasm. Predicted to be part of Piccolo NuA4 histone acetyltransferase complex. Is expressed in several structures, including blood vessel endothelium; brain; heart; retina; and skeletal muscle. Orthologous to human EPC1 (enhancer of polycomb homolog 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E14 (RPKM 19.2), whole brain E14.5 (RPKM 18.8) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Epc1 in Genome Data Viewer
    Location:
    18; 18 A1
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (6435951..6516108, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (6435951..6516108, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L27, pseudogene 3 Neighboring gene prothymosin alpha pseudogene Neighboring gene microRNA 1893 Neighboring gene charged multivesicular body protein 3 pseudogene Neighboring gene RIKEN cDNA 4921524L21 gene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables chromatin-protein adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables enzyme-substrate adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within chromatin organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in histone H2A acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in histone H4 acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in histone acetylation IC
    Inferred by Curator
    more info
    PubMed 
    involved_in histone acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of gene expression, epigenetic ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in positive regulation of DNA-templated transcription IC
    Inferred by Curator
    more info
    PubMed 
    involved_in positive regulation of double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of striated muscle cell differentiation ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in regulation of apoptotic process IC
    Inferred by Curator
    more info
    PubMed 
    involved_in regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of chromatin organization IC
    Inferred by Curator
    more info
    PubMed 
    involved_in regulation of double-strand break repair IC
    Inferred by Curator
    more info
    PubMed 
    acts_upstream_of_or_within regulation of growth IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of NuA4 histone acetyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of Piccolo NuA4 histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of Piccolo NuA4 histone acetyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    part_of nucleosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IC
    Inferred by Curator
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    enhancer of polycomb homolog 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001276350.1NP_001263279.1  enhancer of polycomb homolog 1 isoform 3

      See identical proteins and their annotated locations for NP_001263279.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks several exons in the central and 3' coding regions and includes an alternate 3' terminal exon, resulting in a novel 3' coding region and 3' UTR, compared to variant 2. It encodes isoform 3 which is shorter and has a distinct C-terminus, compared to isoform 2.
      Source sequence(s)
      AC139300, AK040254, AV356347, BB343428, BC038636, BC055805
      Consensus CDS
      CCDS70868.1
      UniProtKB/Swiss-Prot
      Q8C9X6
      UniProtKB/TrEMBL
      A0A6P5P1T3, A0A8C6HIX5, Q6PBH3, Q7TNR8
      Related
      ENSMUSP00000060599.6, ENSMUST00000050542.6
      Conserved Domains (1) summary
      pfam10513
      Location:651
      EPL1; Enhancer of polycomb-like
    2. NM_007935.2NP_031961.1  enhancer of polycomb homolog 1 isoform 1

      See identical proteins and their annotated locations for NP_031961.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR and in the 5' coding region, compared to variant 2. It encodes isoform 1 which is shorter and has a distinct N-terminus, compared to isoform 2.
      Source sequence(s)
      AI849475, AK148194, AK149317, BB207261, BM936825, DV652878
      Consensus CDS
      CCDS37726.1
      UniProtKB/Swiss-Prot
      Q8C9X6
      UniProtKB/TrEMBL
      Q3UEV1, Q3UG01
      Related
      ENSMUSP00000111536.3, ENSMUST00000115870.9
      Conserved Domains (2) summary
      pfam06752
      Location:572763
      E_Pc_C; Enhancer of Polycomb C-terminus
      pfam10513
      Location:198
      EPL1; Enhancer of polycomb-like
    3. NM_027497.3NP_081773.1  enhancer of polycomb homolog 1 isoform 2

      See identical proteins and their annotated locations for NP_081773.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents the longest transcript and encodes the longest isoform (2).
      Source sequence(s)
      AC139300, AF079765, AK040254
      Consensus CDS
      CCDS29041.1
      UniProtKB/Swiss-Prot
      Q8C9X6, Q9Z299
      Related
      ENSMUSP00000028100.7, ENSMUST00000028100.13
      Conserved Domains (2) summary
      pfam06752
      Location:622813
      E_Pc_C; Enhancer of Polycomb C-terminus
      pfam10513
      Location:7148
      EPL1; Enhancer of polycomb-like

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      6435951..6516108 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)