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    CR2 complement C3d receptor 2 [ Homo sapiens (human) ]

    Gene ID: 1380, updated on 6-Apr-2021

    Summary

    Official Symbol
    CR2provided by HGNC
    Official Full Name
    complement C3d receptor 2provided by HGNC
    Primary source
    HGNC:HGNC:2336
    See related
    Ensembl:ENSG00000117322 MIM:120650
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CR; C3DR; CD21; CVID7; SLEB9
    Summary
    This gene encodes a membrane protein, which functions as a receptor for Epstein-Barr virus (EBV) binding on B and T lymphocytes. Genetic variations in this gene are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]
    Expression
    Biased expression in lymph node (RPKM 99.4), spleen (RPKM 44.6) and 1 other tissue See more
    Orthologs
    NEW
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    Genomic context

    See CR2 in Genome Data Viewer
    Location:
    1q32.2
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    109.20210226 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (207454328..207489892)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (207627673..207663237)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene CD55 molecule (Cromer blood group) Neighboring gene uncharacterized LOC105372880 Neighboring gene complement C3b/C4b receptor 1 (Knops blood group) Neighboring gene CD46 molecule pseudogene 1 Neighboring gene complement C3b/C4b receptor 1 like

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Common variable immunodeficiency 2
    MedGen: C3150354 OMIM: 240500 GeneReviews: Not available
    Compare labs
    Common variable immunodeficiency 7
    MedGen: C3542922 OMIM: 614699 GeneReviews: Not available
    Compare labs
    Systemic lupus erythematosus 9
    MedGen: C1970455 OMIM: 610927 GeneReviews: Not available
    Compare labs
    Transferability of type 2 diabetes implicated loci in multi-ethnic cohorts from Southeast Asia.
    GeneReviews: Not available

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    HIV-1 transmission to CD4+ T cells from follicular dendritic cells from lymph nodes of infected patients is inhibited by soluble CD21 PubMed
    Knockdown of complement component receptor 2 (CR2) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 particles (gp120/gp41) bind to MT-2 (CD4+ CR2+) and Raji-3 (CD4- CR2+) cells but not to CEM (CD4+ CR2-) cells, suggesting that the virus binds to CR2 independently of CD4 PubMed
    Envelope surface glycoprotein gp160, precursor env The activation of mitogen-activated protein kinases (MAPKs, including ERK, JNK, and p38MAPK) is induced by incubation of HIV-1 gp160 with CD4+complement receptor type 2 (CR2)+ cells PubMed
    Vif vif HIV-1 Vif downregulates the expression of complement component receptor 2 (CR2) in Vif-expression T cells PubMed
    capsid gag HIV-1 CA p24 is localized to recycling endosomes by CR2 (CD21) and soluble CD21 frees virus from follicular dendritic cells from lymph nodes of HIV infected patients PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    complement binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    complement receptor activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transmembrane signaling receptor activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    virus receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    B cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    B cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    complement activation, alternative pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    complement activation, classical pathway IEA
    Inferred from Electronic Annotation
    more info
     
    complement receptor mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    immune response NAS
    Non-traceable Author Statement
    more info
    PubMed 
    regulation of complement activation TAS
    Traceable Author Statement
    more info
     
    viral entry into host cell IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    extracellular exosome HDA PubMed 
    integral component of membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    receptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    complement receptor type 2
    Names
    EBV receptor
    complement component (3d/Epstein Barr virus) receptor 2
    complement component 3d receptor 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_013006.1 RefSeqGene

      Range
      5001..40596
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_348

    mRNA and Protein(s)

    1. NM_001006658.3NP_001006659.1  complement receptor type 2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001006659.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK301496, AU133057, AW303499, BQ004295, Y00649
      Consensus CDS
      CCDS31007.1
      UniProtKB/Swiss-Prot
      P20023
      Related
      ENSP00000356024.3, ENST00000367057.7
      Conserved Domains (1) summary
      cd00033
      Location:410467
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    2. NM_001877.5NP_001868.2  complement receptor type 2 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001868.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) is missing an in-frame coding exon compared to variant 1, resulting in a shorter isoform (2) lacking an internal protein segment compared to isoform 1.
      Source sequence(s)
      AK301496, AU133057, AW303499, BQ004295, Y00649
      Consensus CDS
      CCDS1478.1
      UniProtKB/Swiss-Prot
      P20023
      Related
      ENSP00000356025.3, ENST00000367058.7
      Conserved Domains (1) summary
      cd00033
      Location:410467
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

      Range
      207454328..207489892
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011509206.3XP_011507508.1  complement receptor type 2 isoform X1

      Conserved Domains (1) summary
      cd00033
      Location:287344
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
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