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    ABRA actin binding Rho activating protein [ Homo sapiens (human) ]

    Gene ID: 137735, updated on 28-Oct-2024

    Summary

    Official Symbol
    ABRAprovided by HGNC
    Official Full Name
    actin binding Rho activating proteinprovided by HGNC
    Primary source
    HGNC:HGNC:30655
    See related
    Ensembl:ENSG00000174429 MIM:609747; AllianceGenome:HGNC:30655
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    STARS
    Summary
    Predicted to enable actin binding activity. Predicted to be involved in actin cytoskeleton organization; positive regulation of Rho protein signal transduction; and regulation of DNA-templated transcription. Predicted to act upstream of or within positive regulation of DNA-templated transcription and protein import into nucleus. Located in plasma membrane. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in heart (RPKM 6.8), esophagus (RPKM 1.8) and 2 other tissues See more
    Orthologs
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    Genomic context

    See ABRA in Genome Data Viewer
    Location:
    8q23.1
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (106759483..106770244, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (107887295..107936923, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (107771711..107782472, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene oxidation resistance 1 Neighboring gene transgelin 2 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27803 Neighboring gene RNA, U7 small nuclear 84 pseudogene Neighboring gene uncharacterized LOC124902004 Neighboring gene uncharacterized LOC124902066

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables actin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of Rho protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of Rho protein signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein import into nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in actin cytoskeleton ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
     
    is_active_in sarcomere IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in sarcomere ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    actin-binding Rho-activating protein
    Names
    striated muscle activator of Rho-dependent signaling

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_139166.5NP_631905.1  actin-binding Rho-activating protein

      See identical proteins and their annotated locations for NP_631905.1

      Status: VALIDATED

      Source sequence(s)
      AL832152, BC105103
      Consensus CDS
      CCDS6305.1
      UniProtKB/Swiss-Prot
      Q8N0Z2
      Related
      ENSP00000311436.3, ENST00000311955.4
      Conserved Domains (1) summary
      pfam14705
      Location:305379
      Costars; Costars

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      106759483..106770244 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      107887295..107936923 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054359752.1XP_054215727.1  actin-binding Rho-activating protein isoform X1

      UniProtKB/Swiss-Prot
      Q8N0Z2