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    Mark2 MAP/microtubule affinity regulating kinase 2 [ Mus musculus (house mouse) ]

    Gene ID: 13728, updated on 9-Sep-2018

    Summary

    Official Symbol
    Mark2provided by MGI
    Official Full Name
    MAP/microtubule affinity regulating kinase 2provided by MGI
    Primary source
    MGI:MGI:99638
    See related
    Ensembl:ENSMUSG00000024969 Vega:OTTMUSG00000035747
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Emk; EMK-1; Par-1; Par-1b
    Expression
    Ubiquitous expression in duodenum adult (RPKM 24.0), colon adult (RPKM 22.0) and 28 other tissues See more
    Orthologs

    Genomic context

    See Mark2 in Genome Data Viewer
    Location:
    19 A; 19 5.32 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 19 NC_000085.6 (7275396..7341867, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (7349886..7416334, complement)

    Chromosome 19 - NC_000085.6Genomic Context describing neighboring genes Neighboring gene N(alpha)-acetyltransferase 40, NatD catalytic subunit Neighboring gene REST corepressor 2 Neighboring gene uncharacterized LOC102639888 Neighboring gene spindlin interactor and repressor of chromatin binding Neighboring gene RIKEN cDNA 1700105P06 gene Neighboring gene predicted gene, 46647

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA4207, mKIAA4207

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    lipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein N-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    tau protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    tau-protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    tau-protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    axon development ISO
    Inferred from Sequence Orthology
    more info
     
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    establishment of cell polarity ISO
    Inferred from Sequence Orthology
    more info
     
    establishment or maintenance of cell polarity regulating cell shape ISO
    Inferred from Sequence Orthology
    more info
     
    establishment or maintenance of epithelial cell apical/basal polarity ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    neuron migration ISO
    Inferred from Sequence Orthology
    more info
     
    peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of axonogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of microtubule binding ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of microtubule cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    actin filament ISO
    Inferred from Sequence Orthology
    more info
     
    basal cortex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    lateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    microtubule bundle ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    serine/threonine-protein kinase MARK2
    Names
    ELKL motif kinase 1
    PAR1 homolog b
    NP_001073857.1
    NP_001073858.1
    NP_001073859.1
    NP_031954.2
    XP_006526704.1
    XP_006526705.1
    XP_006526706.1
    XP_006526707.1
    XP_006526708.1
    XP_006526709.1
    XP_006526710.1
    XP_006526711.1
    XP_006526713.1
    XP_006526715.1
    XP_006526717.1
    XP_006526719.1
    XP_011245441.1
    XP_017173547.1
    XP_017173548.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080388.2NP_001073857.1  serine/threonine-protein kinase MARK2 isoform 2

      See identical proteins and their annotated locations for NP_001073857.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
      Source sequence(s)
      AC140307, AK045329, BY209123, BY235571, CJ111884
      Consensus CDS
      CCDS50378.1
      UniProtKB/Swiss-Prot
      Q05512
      UniProtKB/TrEMBL
      A0A0R4J227
      Related
      ENSMUSP00000127827.1, OTTMUSP00000050349, ENSMUST00000164205.7, OTTMUST00000091401
      Conserved Domains (4) summary
      cd12201
      Location:623721
      MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
      smart00220
      Location:53304
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14406
      Location:322363
      UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
      cd14072
      Location:52304
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    2. NM_001080389.2NP_001073858.1  serine/threonine-protein kinase MARK2 isoform 3

      See identical proteins and their annotated locations for NP_001073858.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks one exon and contains an alternate exon in the 3' coding region, compared to variant 1. The encoded isoform (3) is shorter, compared to isoform 1.
      Source sequence(s)
      AC140307, AK045329, BY209123, BY235571, CJ111884, DV650107
      Consensus CDS
      CCDS37903.1
      UniProtKB/Swiss-Prot
      Q05512
      UniProtKB/TrEMBL
      A0A0R4J0B1
      Related
      ENSMUSP00000032557.8, OTTMUSP00000050348, ENSMUST00000032557.14, OTTMUST00000091400
      Conserved Domains (4) summary
      cd12201
      Location:632730
      MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
      smart00220
      Location:53304
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14406
      Location:322363
      UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
      cd14072
      Location:52304
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    3. NM_001080390.2NP_001073859.1  serine/threonine-protein kinase MARK2 isoform 4

      See identical proteins and their annotated locations for NP_001073859.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks part of the 5' coding region, uses an alternate 5'-terminal exon, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (4) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC140307, AK045329, CA561509
      Consensus CDS
      CCDS37905.1
      UniProtKB/Swiss-Prot
      Q05512
      UniProtKB/TrEMBL
      Q3T9A3
      Related
      ENSMUSP00000025921.8, OTTMUSP00000050350, ENSMUST00000025921.14, OTTMUST00000091402
      Conserved Domains (4) summary
      cd12201
      Location:644742
      MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
      smart00220
      Location:20271
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14406
      Location:289330
      UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
      cd14072
      Location:19271
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    4. NM_007928.3NP_031954.2  serine/threonine-protein kinase MARK2 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC140307, AK045329, BY209123, BY235571, CJ111884
      Consensus CDS
      CCDS37904.1
      UniProtKB/Swiss-Prot
      Q05512
      UniProtKB/TrEMBL
      E9QMP6
      Related
      ENSMUSP00000131684.1, OTTMUSP00000050352, ENSMUST00000165965.7, OTTMUST00000091404
      Conserved Domains (4) summary
      cd12201
      Location:677775
      MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
      smart00220
      Location:53304
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14406
      Location:322363
      UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
      cd14072
      Location:52304
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000085.6 Reference GRCm38.p4 C57BL/6J

      Range
      7275396..7341867 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006526645.2XP_006526708.1  serine/threonine-protein kinase MARK2 isoform X4

      See identical proteins and their annotated locations for XP_006526708.1

      Conserved Domains (4) summary
      cd12201
      Location:709807
      MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
      smart00220
      Location:20271
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14406
      Location:289330
      UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
      cd14072
      Location:19271
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    2. XM_006526643.2XP_006526706.1  serine/threonine-protein kinase MARK2 isoform X3

      Conserved Domains (4) summary
      cd12201
      Location:742840
      MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
      smart00220
      Location:53304
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14406
      Location:322363
      UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
      cd14072
      Location:52304
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    3. XM_006526647.2XP_006526710.1  serine/threonine-protein kinase MARK2 isoform X5

      Conserved Domains (4) summary
      cd12201
      Location:698796
      MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
      smart00220
      Location:63314
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14406
      Location:332373
      UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
      cd14072
      Location:62314
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    4. XM_006526642.3XP_006526705.1  serine/threonine-protein kinase MARK2 isoform X2

      Conserved Domains (4) summary
      cd12201
      Location:743841
      MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
      smart00220
      Location:63314
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14406
      Location:332373
      UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
      cd14072
      Location:62314
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    5. XM_006526641.3XP_006526704.1  serine/threonine-protein kinase MARK2 isoform X1

      Conserved Domains (4) summary
      cd12201
      Location:752850
      MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
      smart00220
      Location:63314
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14406
      Location:332373
      UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
      cd14072
      Location:62314
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    6. XM_017318058.1XP_017173547.1  serine/threonine-protein kinase MARK2 isoform X11

    7. XM_006526654.3XP_006526717.1  serine/threonine-protein kinase MARK2 isoform X10

      Conserved Domains (4) summary
      cd12201
      Location:627725
      MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
      smart00220
      Location:63314
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14406
      Location:332373
      UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
      cd14072
      Location:62314
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    8. XM_006526652.3XP_006526715.1  serine/threonine-protein kinase MARK2 isoform X9

      Conserved Domains (4) summary
      cd12201
      Location:642740
      MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
      smart00220
      Location:63314
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14406
      Location:332373
      UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
      cd14072
      Location:62314
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    9. XM_006526650.3XP_006526713.1  serine/threonine-protein kinase MARK2 isoform X7

      Conserved Domains (4) summary
      cd12201
      Location:681779
      MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
      smart00220
      Location:63314
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14406
      Location:332373
      UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
      cd14072
      Location:62314
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    10. XM_006526648.3XP_006526711.1  serine/threonine-protein kinase MARK2 isoform X6

      Related
      ENSMUSP00000129506.1, OTTMUSP00000050351, ENSMUST00000171721.7, OTTMUST00000091403
      Conserved Domains (4) summary
      cd12201
      Location:696794
      MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
      smart00220
      Location:63314
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14406
      Location:332373
      UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
      cd14072
      Location:62314
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    11. XM_006526646.3XP_006526709.1  serine/threonine-protein kinase MARK2 isoform X4

      See identical proteins and their annotated locations for XP_006526709.1

      Conserved Domains (4) summary
      cd12201
      Location:709807
      MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
      smart00220
      Location:20271
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14406
      Location:289330
      UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
      cd14072
      Location:19271
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    12. XM_006526644.3XP_006526707.1  serine/threonine-protein kinase MARK2 isoform X4

      See identical proteins and their annotated locations for XP_006526707.1

      Conserved Domains (4) summary
      cd12201
      Location:709807
      MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
      smart00220
      Location:20271
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14406
      Location:289330
      UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
      cd14072
      Location:19271
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    13. XM_017318059.1XP_017173548.1  serine/threonine-protein kinase MARK2 isoform X13

    14. XM_011247139.1XP_011245441.1  serine/threonine-protein kinase MARK2 isoform X8

      Conserved Domains (4) summary
      cd12201
      Location:629727
      MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
      smart00220
      Location:20271
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14406
      Location:289330
      UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
      cd14072
      Location:19271
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    15. XM_006526656.3XP_006526719.1  serine/threonine-protein kinase MARK2 isoform X12

      Conserved Domains (3) summary
      smart00220
      Location:63314
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14406
      Location:332373
      UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
      cd14072
      Location:62314
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
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