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    Elk4 ELK4, member of ETS oncogene family [ Mus musculus (house mouse) ]

    Gene ID: 13714, updated on 26-Sep-2022

    Summary

    Official Symbol
    Elk4provided by MGI
    Official Full Name
    ELK4, member of ETS oncogene familyprovided by MGI
    Primary source
    MGI:MGI:102853
    See related
    Ensembl:ENSMUSG00000026436 AllianceGenome:MGI:102853
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sap1; SAP-1; 2310011G17Rik; A130026I01Rik
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Predicted to be involved in cell differentiation; negative regulation of transcription by RNA polymerase II; and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within histone H3 deacetylation. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; genitourinary system; hemolymphoid system; and retina. Orthologous to human ELK4 (ETS transcription factor ELK4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in thymus adult (RPKM 13.6), spleen adult (RPKM 6.7) and 27 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Elk4 in Genome Data Viewer
    Location:
    1; 1 E4
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (131935129..131954186)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (132007577..132026448)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene nuclear casein kinase and cyclin-dependent kinase substrate 1 Neighboring gene solute carrier family 45, member 3 Neighboring gene major facilitator superfamily domain containing 4A Neighboring gene RIKEN cDNA 4833413N01 gene Neighboring gene predicted gene, 37120

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Endonuclease-mediated (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    ETS domain-containing protein Elk-4
    Names
    SRF accessory protein 1
    serum response factor accessory protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001376954.1NP_001363883.1  ETS domain-containing protein Elk-4 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC107837
      UniProtKB/Swiss-Prot
      A6H693
      UniProtKB/TrEMBL
      A0A8C6HZJ9
      Conserved Domains (2) summary
      smart00413
      Location:1788
      ETS; erythroblast transformation specific domain
      PHA03247
      Location:170349
      PHA03247; large tegument protein UL36; Provisional
    2. NM_001376955.1NP_001363884.1  ETS domain-containing protein Elk-4 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC107837
      UniProtKB/Swiss-Prot
      A6H693
      UniProtKB/TrEMBL
      A0A8C6HZJ9
      Conserved Domains (2) summary
      smart00413
      Location:1788
      ETS; erythroblast transformation specific domain
      PHA03247
      Location:170349
      PHA03247; large tegument protein UL36; Provisional
    3. NM_001376956.1NP_001363885.1  ETS domain-containing protein Elk-4 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC107837
      UniProtKB/Swiss-Prot
      A6H693
      UniProtKB/TrEMBL
      A0A8C6HZJ9
      Conserved Domains (2) summary
      smart00413
      Location:1788
      ETS; erythroblast transformation specific domain
      PHA03247
      Location:170349
      PHA03247; large tegument protein UL36; Provisional
    4. NM_001376957.1NP_001363886.1  ETS domain-containing protein Elk-4 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC107837
      UniProtKB/Swiss-Prot
      A6H693
      UniProtKB/TrEMBL
      A0A8C6HZJ9
      Related
      ENSMUSP00000027696.4, ENSMUST00000027696.10
      Conserved Domains (2) summary
      smart00413
      Location:1788
      ETS; erythroblast transformation specific domain
      PHA03247
      Location:170349
      PHA03247; large tegument protein UL36; Provisional
    5. NM_001376958.1NP_001363887.1  ETS domain-containing protein Elk-4 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC107837
      UniProtKB/Swiss-Prot
      A6H693
      UniProtKB/TrEMBL
      A0A8C6HZJ9
      Conserved Domains (2) summary
      smart00413
      Location:1788
      ETS; erythroblast transformation specific domain
      PHA03247
      Location:170349
      PHA03247; large tegument protein UL36; Provisional
    6. NM_001376959.1NP_001363888.1  ETS domain-containing protein Elk-4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC107837
      Conserved Domains (1) summary
      smart00413
      Location:1769
      ETS; erythroblast transformation specific domain
    7. NM_007923.3NP_031949.2  ETS domain-containing protein Elk-4 isoform 1

      See identical proteins and their annotated locations for NP_031949.2

      Status: VALIDATED

      Source sequence(s)
      AC107837
      Consensus CDS
      CCDS35704.1
      UniProtKB/Swiss-Prot
      A6H693, P41158
      UniProtKB/TrEMBL
      A0A8C6HZJ9
      Related
      ENSMUSP00000083743.6, ENSMUST00000086556.12
      Conserved Domains (2) summary
      smart00413
      Location:1788
      ETS; erythroblast transformation specific domain
      PHA03247
      Location:170349
      PHA03247; large tegument protein UL36; Provisional

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      131935129..131954186
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036158973.1XP_036014866.1  ETS domain-containing protein Elk-4 isoform X1

      UniProtKB/Swiss-Prot
      A6H693
      UniProtKB/TrEMBL
      A0A8C6HZJ9
      Conserved Domains (2) summary
      smart00413
      Location:1788
      ETS; erythroblast transformation specific domain
      PHA03247
      Location:170349
      PHA03247; large tegument protein UL36; Provisional