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    Eif4g2 eukaryotic translation initiation factor 4, gamma 2 [ Mus musculus (house mouse) ]

    Gene ID: 13690, updated on 31-Jan-2019

    Summary

    Official Symbol
    Eif4g2provided by MGI
    Official Full Name
    eukaryotic translation initiation factor 4, gamma 2provided by MGI
    Primary source
    MGI:MGI:109207
    See related
    Ensembl:ENSMUSG00000005610
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p97; Nat1; DAP-5; Natm1; E130105L11Rik
    Summary
    Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F), which is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. The protein encoded by this gene shares similarity with the C-terminal region of eIF4G, that contains the binding sites for eIF4A and eIF3; eIF4G in addition, contains a binding site for eIF4E at the N-terminus. Unlike eIF4G which supports cap-dependent and independent translation, this gene product functions as a general repressor of translation by forming translationally inactive complexes. Transgene expression of the apolipoprotein B mRNA-editing enzyme (APOBEC-1) causes extensive editing of this mRNA, which could contribute to the potent oncogenesis induced by overexpression of APOBEC-1. In vitro and in vivo studies in human indicate that translation of this mRNA initiates exclusively at a non-AUG (GUG) codon. This also appears to be true for mouse. Two alternatively spliced transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 106.9), CNS E14 (RPKM 96.1) and 24 other tissues See more
    Orthologs

    Genomic context

    See Eif4g2 in Genome Data Viewer
    Location:
    7 E3; 7 58.0 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (111067985..111083030, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (118211499..118226544, complement)

    Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene MRV integration site 1 Neighboring gene predicted gene 16336 Neighboring gene CTR9 homolog, Paf1/RNA polymerase II complex component Neighboring gene RIKEN cDNA 1700012D14 gene Neighboring gene predicted gene, 33098

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    translation factor activity, RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    translation initiation factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    translation initiation factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    cellular macromolecule biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of axon extension ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of dendritic spine development ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of translation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of translation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of translational initiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of translational initiation ISO
    Inferred from Sequence Orthology
    more info
     
    translation IEA
    Inferred from Electronic Annotation
    more info
     
    translational initiation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    axon ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    eukaryotic translation initiation factor 4F complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    eukaryotic translation initiation factor 4F complex ISO
    Inferred from Sequence Orthology
    more info
     
    postsynaptic density EXP
    Inferred from Experiment
    more info
    PubMed 
    postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    eukaryotic translation initiation factor 4 gamma 2
    Names
    eIF-4-gamma 2
    eIF-4G 2
    eIF4G 2
    eif4g2
    novel APOBEC-1 target 1
    translation repressor Nat1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001040131.2NP_001035221.1  eukaryotic translation initiation factor 4 gamma 2 isoform 2

      See identical proteins and their annotated locations for NP_001035221.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame segment, compared to variant 1, resulting in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AC150312, AC159206, AI874618, BC043034
      Consensus CDS
      CCDS40087.1
      UniProtKB/Swiss-Prot
      Q62448
      Related
      ENSMUSP00000125375.1, ENSMUST00000161051.7
      Conserved Domains (4) summary
      cd11559
      Location:701837
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      smart00544
      Location:505618
      MA3; Domain in DAP-5, eIF4G, MA-3 and other proteins
      pfam02854
      Location:78308
      MIF4G; MIF4G domain
      pfam11235
      Location:412509
      Med25_SD1; Mediator complex subunit 25 synapsin 1
    2. NM_013507.3NP_038535.2  eukaryotic translation initiation factor 4 gamma 2 isoform 1

      See identical proteins and their annotated locations for NP_038535.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer protein (isoform 1).
      Source sequence(s)
      AC150312, AI874618, BC043034
      Consensus CDS
      CCDS40088.1
      UniProtKB/Swiss-Prot
      Q62448
      UniProtKB/TrEMBL
      A0JNY7
      Related
      ENSMUSP00000124551.1, ENSMUST00000162415.8
      Conserved Domains (3) summary
      cd11559
      Location:739875
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      smart00544
      Location:543656
      MA3; Domain in DAP-5, eIF4G, MA-3 and other proteins
      pfam02854
      Location:78308
      MIF4G; MIF4G domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

      Range
      111067985..111083030 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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