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    Eif4ebp2 eukaryotic translation initiation factor 4E binding protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 13688, updated on 12-Mar-2019

    Summary

    Official Symbol
    Eif4ebp2provided by MGI
    Official Full Name
    eukaryotic translation initiation factor 4E binding protein 2provided by MGI
    Primary source
    MGI:MGI:109198
    See related
    Ensembl:ENSMUSG00000020091
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4E-BP2; PHAS-II; AA792569; BC010348; 2810011I19Rik
    Expression
    Ubiquitous expression in thymus adult (RPKM 49.7), liver adult (RPKM 46.0) and 28 other tissues See more
    Orthologs

    Genomic context

    See Eif4ebp2 in Genome Data Viewer
    Location:
    10 B4; 10 32.21 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 10 NC_000076.6 (61428491..61452790, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (60895245..60915417, complement)

    Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene phosphatase domain containing, paladin 1 Neighboring gene nodal Neighboring gene uncharacterized LOC108167814 Neighboring gene leucine rich repeat containing 20 Neighboring gene oligosaccharyltransferase complex subunit pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    • Longevity regulating pathway - multiple species, organism-specific biosystem (from KEGG)
      Longevity regulating pathway - multiple species, organism-specific biosystemAging is a complex process of accumulation of molecular, cellular, and organ damage, leading to loss of function and increased vulnerability to disease and death. Despite the complexity of aging, rec...
    • Longevity regulating pathway - multiple species, conserved biosystem (from KEGG)
      Longevity regulating pathway - multiple species, conserved biosystemAging is a complex process of accumulation of molecular, cellular, and organ damage, leading to loss of function and increased vulnerability to disease and death. Despite the complexity of aging, rec...
    • RNA transport, organism-specific biosystem (from KEGG)
      RNA transport, organism-specific biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
    • RNA transport, conserved biosystem (from KEGG)
      RNA transport, conserved biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
    • Translation Factors, organism-specific biosystem (from WikiPathways)
      Translation Factors, organism-specific biosystem
      Translation Factors

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC141219

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    eukaryotic initiation factor 4E binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    eukaryotic initiation factor 4E binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    translation repressor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    TOR signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cAMP-mediated signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    insulin receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    modulation of chemical synaptic transmission IDA
    Inferred from Direct Assay
    more info
    PubMed 
    modulation of chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of translation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of translational initiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of synaptic plasticity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of translation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of translational initiation TAS
    Traceable Author Statement
    more info
    PubMed 
    social behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    postsynapse ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    eukaryotic translation initiation factor 4E-binding protein 2
    Names
    eIF4E-binding protein 2
    phosphorylated heat- and acid-stable protein regulated by insulin 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010124.2NP_034254.1  eukaryotic translation initiation factor 4E-binding protein 2

      See identical proteins and their annotated locations for NP_034254.1

      Status: PROVISIONAL

      Source sequence(s)
      AC122197
      Consensus CDS
      CCDS23879.1
      UniProtKB/Swiss-Prot
      P70445
      UniProtKB/TrEMBL
      Q3UFP6
      Related
      ENSMUSP00000020288.7, ENSMUST00000020288.14
      Conserved Domains (1) summary
      pfam05456
      Location:13120
      eIF_4EBP; Eukaryotic translation initiation factor 4E binding protein (EIF4EBP)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000076.6 Reference GRCm38.p4 C57BL/6J

      Range
      61428491..61452790 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017313793.1XP_017169282.1  eukaryotic translation initiation factor 4E-binding protein 2 isoform X1

      UniProtKB/Swiss-Prot
      P70445
      UniProtKB/TrEMBL
      Q3UFP6
      Conserved Domains (1) summary
      pfam05456
      Location:13120
      eIF_4EBP; Eukaryotic translation initiation factor 4E binding protein (EIF4EBP)
    2. XM_017313792.1XP_017169281.1  eukaryotic translation initiation factor 4E-binding protein 2 isoform X1

      UniProtKB/Swiss-Prot
      P70445
      UniProtKB/TrEMBL
      Q3UFP6
      Conserved Domains (1) summary
      pfam05456
      Location:13120
      eIF_4EBP; Eukaryotic translation initiation factor 4E binding protein (EIF4EBP)
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