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    Eif4e eukaryotic translation initiation factor 4E [ Mus musculus (house mouse) ]

    Gene ID: 13684, updated on 14-Sep-2021

    Summary

    Official Symbol
    Eif4eprovided by MGI
    Official Full Name
    eukaryotic translation initiation factor 4Eprovided by MGI
    Primary source
    MGI:MGI:95305
    See related
    Ensembl:ENSMUSG00000028156
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    If4; If4e; eIF-4; eIF-4E; EG668879; Eif4e-ps
    Summary
    This gene encodes a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of messenger RNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the 5'-cap structure. Association of this protein with the 4F complex is the rate-limiting step in translation initiation. This gene acts as a proto-oncogene, and its expression and activation is associated with transformation and tumorigenesis. It has also been associated with autism spectrum disorders. Consistently, knockout of this gene results in increased translation of neuroligins, postsynaptic proteins linked to autism spectrum disorders. Pseudogenes of this gene are found on other chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 11.1), CNS E11.5 (RPKM 11.0) and 25 other tissues See more
    Orthologs
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    Genomic context

    See Eif4e in Genome Data Viewer
    Location:
    3 G3; 3 64.3 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (138231952..138265457)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (138526191..138559696)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (138189155..138220563)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene alcohol dehydrogenase 5 (class III), chi polypeptide Neighboring gene methionyl aminopeptidase 1 Neighboring gene predicted gene, 32553 Neighboring gene microRNA 1956 Neighboring gene predicted gene, 29762 Neighboring gene solute carrier family 5 (sodium-dependent vitamin transporter), member 6 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC103177

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA 7-methylguanosine cap binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables RNA 7-methylguanosine cap binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables eukaryotic initiation factor 4G binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables translation initiation factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables translation initiation factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables translation regulator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables translation regulator activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in P-body ISO
    Inferred from Sequence Orthology
    more info
     
    part_of RISC complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromatoid body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic ribonucleoprotein granule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic stress granule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    part_of eukaryotic translation initiation factor 4F complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of eukaryotic translation initiation factor 4F complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    part_of mRNA cap binding complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of mRNA cap binding complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    eukaryotic translation initiation factor 4E
    Names
    eIF-4F 25 kDa subunit
    mRNA cap-binding protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001313980.1NP_001300909.1  eukaryotic translation initiation factor 4E isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and contains an alternate exon in the 5' coding region that results in use of a downstream start codon compared to variant 1. It encodes isoform 2, which has a shorter N-terminus than isoform 1.
      Source sequence(s)
      AC113988, AK167097, BP770650
      Consensus CDS
      CCDS84679.1
      UniProtKB/TrEMBL
      A0A0G2JFB4, Q3TK95
      Related
      ENSMUSP00000143104.2, ENSMUST00000196990.5
      Conserved Domains (1) summary
      pfam01652
      Location:2112
      IF4E; Eukaryotic initiation factor 4E
    2. NM_007917.4NP_031943.3  eukaryotic translation initiation factor 4E isoform 1

      See identical proteins and their annotated locations for NP_031943.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC113988, AK082867, AK167097, BP770650, CN714483
      Consensus CDS
      CCDS38654.1
      UniProtKB/Swiss-Prot
      P63073
      UniProtKB/TrEMBL
      Q3TK95, Q8C470
      Related
      ENSMUSP00000029803.8, ENSMUST00000029803.12
      Conserved Domains (1) summary
      pfam01652
      Location:38197
      IF4E; Eukaryotic initiation factor 4E

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      138231952..138265457
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006500993.4XP_006501056.1  eukaryotic translation initiation factor 4E isoform X1

      Conserved Domains (1) summary
      pfam01652
      Location:51210
      IF4E; Eukaryotic initiation factor 4E
    2. XM_036162887.1XP_036018780.1  eukaryotic translation initiation factor 4E isoform X2

      Related
      ENSMUSP00000143690.2, ENSMUST00000200020.5
      Conserved Domains (1) summary
      pfam01652
      Location:38197
      IF4E; Eukaryotic initiation factor 4E
    3. XM_017319453.3XP_017174942.1  eukaryotic translation initiation factor 4E isoform X3

      UniProtKB/TrEMBL
      A0A0G2JFB4
      Conserved Domains (1) summary
      pfam01652
      Location:2112
      IF4E; Eukaryotic initiation factor 4E
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