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    Eif4a2 eukaryotic translation initiation factor 4A2 [ Mus musculus (house mouse) ]

    Gene ID: 13682, updated on 22-Aug-2021

    Summary

    Official Symbol
    Eif4a2provided by MGI
    Official Full Name
    eukaryotic translation initiation factor 4A2provided by MGI
    Primary source
    MGI:MGI:106906
    See related
    Ensembl:ENSMUSG00000022884
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Eif; Eif4; Ddx2b; BM-010; eIF4A-II; eIF-4A-II; 4833432N07Rik
    Expression
    Broad expression in CNS E18 (RPKM 124.6), bladder adult (RPKM 120.0) and 24 other tissues See more
    Orthologs
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    Genomic context

    See Eif4a2 in Genome Data Viewer
    Location:
    16 B1; 16 13.93 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (22924846..22932882)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (23107468..23114132)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (23107552..23114205)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene kininogen 1 Neighboring gene AT rich interactive domain 1A (SWI-like) pseudogene Neighboring gene predicted gene, 30693 Neighboring gene small nucleolar RNA, C/D box 2 Neighboring gene predicted gene, 24201 Neighboring gene small nucleolar RNA, H/ACA box 81 Neighboring gene predicted gene, 26447 Neighboring gene predicted gene, 24616 Neighboring gene replication factor C (activator 1) 4 Neighboring gene adiponectin enhancer region Neighboring gene adiponectin, C1Q and collagen domain containing

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • 4833432N07

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    eukaryotic initiation factor 4A-II
    Names
    ATP-dependent RNA helicase eIF4A-2
    NP_001116509.1
    NP_001116510.1
    NP_001334108.1
    NP_038534.2
    XP_006521847.1
    XP_006521848.1
    XP_030104824.1
    XP_030104825.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001123037.2NP_001116509.1  eukaryotic initiation factor 4A-II isoform b

      See identical proteins and their annotated locations for NP_001116509.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in its 5' coding region, which leads to a frameshift and use of an alternate start codon, compared to variant 1. The encoded isoform (b) has a shorter and distinct N-terminus, compared to isoform a.
      Source sequence(s)
      AC154540, AK076509, BC094422, BY286182, CF723811
      Consensus CDS
      CCDS49806.1
      UniProtKB/Swiss-Prot
      P10630
      UniProtKB/TrEMBL
      E9Q561, Q52KC1
      Related
      ENSMUSP00000127030.2, ENSMUST00000168891.8
      Conserved Domains (1) summary
      PTZ00424
      Location:18312
      PTZ00424; helicase 45; Provisional
    2. NM_001123038.2NP_001116510.1  eukaryotic initiation factor 4A-II isoform c

      See identical proteins and their annotated locations for NP_001116510.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 3'-terminal exon, which leads to a frameshift, compared to variant 1. The encoded isoform (c) has a shorter and distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AC154540, AK076509, BC094422, BG091741, BY286182, CF723811, CF898280, CK623185
      Consensus CDS
      CCDS49805.1
      UniProtKB/Swiss-Prot
      P10630
      UniProtKB/TrEMBL
      Q52KC1, Q8BTU6
      Related
      ENSMUSP00000090876.5, ENSMUST00000077605.12
      Conserved Domains (1) summary
      PTZ00424
      Location:21360
      PTZ00424; helicase 45; Provisional
    3. NM_001347179.2NP_001334108.1  eukaryotic initiation factor 4A-II isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The encoded isoform (d) is longer than isoform a.
      Source sequence(s)
      AC154540
      Consensus CDS
      CCDS84218.1
      UniProtKB/Swiss-Prot
      P10630
      Conserved Domains (1) summary
      PTZ00424
      Location:9408
      PTZ00424; helicase 45; Provisional
    4. NM_013506.3NP_038534.2  eukaryotic initiation factor 4A-II isoform a

      See identical proteins and their annotated locations for NP_038534.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform a.
      Source sequence(s)
      AC154540, AK076509, BC094422, BY286182, CF723811
      Consensus CDS
      CCDS28074.1
      UniProtKB/Swiss-Prot
      P10630
      UniProtKB/TrEMBL
      Q52KC1
      Related
      ENSMUSP00000023599.7, ENSMUST00000023599.13
      Conserved Domains (1) summary
      PTZ00424
      Location:21407
      PTZ00424; helicase 45; Provisional

    RNA

    1. NR_110335.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) includes an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC154540, AK076509, AK132969, BC094422, BY286182, CF723811
    2. NR_152586.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) contains an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC154540

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      22924846..22932882
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006521784.4XP_006521847.1  eukaryotic initiation factor 4A-II isoform X1

      See identical proteins and their annotated locations for XP_006521847.1

      Related
      ENSMUSP00000156170.2, ENSMUST00000232287.2
      Conserved Domains (1) summary
      PTZ00424
      Location:9361
      PTZ00424; helicase 45; Provisional
    2. XM_006521785.3XP_006521848.1  eukaryotic initiation factor 4A-II isoform X2

      See identical proteins and their annotated locations for XP_006521848.1

      UniProtKB/TrEMBL
      E9Q561
      Conserved Domains (1) summary
      PTZ00424
      Location:18312
      PTZ00424; helicase 45; Provisional
    3. XM_030248964.1XP_030104824.1  eukaryotic initiation factor 4A-II isoform X3

      Conserved Domains (1) summary
      PTZ00424
      Location:18265
      PTZ00424; helicase 45; Provisional
    4. XM_030248965.1XP_030104825.1  eukaryotic initiation factor 4A-II isoform X3

      Conserved Domains (1) summary
      PTZ00424
      Location:18265
      PTZ00424; helicase 45; Provisional

    RNA

    1. XR_384524.4 RNA Sequence

    2. XR_384525.4 RNA Sequence

    3. XR_003951756.1 RNA Sequence

    4. XR_003951757.1 RNA Sequence

      Related
      ENSMUST00000147117.8
    5. XR_003951758.1 RNA Sequence

    6. XR_003951759.1 RNA Sequence

      Related
      ENSMUST00000131871.8
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