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    Eif4a2 eukaryotic translation initiation factor 4A2 [ Mus musculus (house mouse) ]

    Gene ID: 13682, updated on 31-Jan-2019

    Summary

    Official Symbol
    Eif4a2provided by MGI
    Official Full Name
    eukaryotic translation initiation factor 4A2provided by MGI
    Primary source
    MGI:MGI:106906
    See related
    Ensembl:ENSMUSG00000022884
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Eif4; Ddx2b; BM-010; eIF4A-II; eIF-4A-II; 4833432N07Rik
    Expression
    Broad expression in CNS E18 (RPKM 124.6), bladder adult (RPKM 120.0) and 24 other tissues See more
    Orthologs

    Genomic context

    See Eif4a2 in Genome Data Viewer
    Location:
    16 B1; 16 13.93 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 16 NC_000082.6 (23107402..23114132)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (23107552..23114205)

    Chromosome 16 - NC_000082.6Genomic Context describing neighboring genes Neighboring gene AT rich interactive domain 1A (SWI-like) pseudogene Neighboring gene predicted gene, 30693 Neighboring gene small nucleolar RNA, C/D box 2 Neighboring gene small nucleolar RNA, H/ACA box 81 Neighboring gene replication factor C (activator 1) 4 Neighboring gene adiponectin, C1Q and collagen domain containing Neighboring gene RIKEN cDNA C730014E05 gene Neighboring gene predicted pseudogene 6630

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • 4833432N07

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    ATP-dependent RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    ATPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    translation initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cellular response to leukemia inhibitory factor IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    negative regulation of RNA-directed 5'-3' RNA polymerase activity ISO
    Inferred from Sequence Orthology
    more info
     
    translation IEA
    Inferred from Electronic Annotation
    more info
     
    translational initiation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    eukaryotic initiation factor 4A-II
    Names
    ATP-dependent RNA helicase eIF4A-2
    NP_001116509.1
    NP_001116510.1
    NP_038534.2
    XP_006521846.1
    XP_006521847.1
    XP_006521848.1
    XP_017172362.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001123037.2NP_001116509.1  eukaryotic initiation factor 4A-II isoform b

      See identical proteins and their annotated locations for NP_001116509.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in its 5' coding region, which leads to a frameshift and use of an alternate start codon, compared to variant 1. The encoded isoform (b) has a shorter and distinct N-terminus, compared to isoform a.
      Source sequence(s)
      AC154540, AK076509, BC094422, BY286182, CF723811
      Consensus CDS
      CCDS49806.1
      UniProtKB/Swiss-Prot
      P10630
      UniProtKB/TrEMBL
      E9Q561, Q52KC1
      Related
      ENSMUSP00000127030.1, ENSMUST00000168891.7
      Conserved Domains (2) summary
      cd00079
      Location:152267
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      cl21455
      Location:18141
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    2. NM_001123038.2NP_001116510.1  eukaryotic initiation factor 4A-II isoform c

      See identical proteins and their annotated locations for NP_001116510.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 3'-terminal exon, which leads to a frameshift, compared to variant 1. The encoded isoform (c) has a shorter and distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AC154540, AK076509, BC094422, BG091741, BY286182, CF723811, CF898280, CK623185
      Consensus CDS
      CCDS49805.1
      UniProtKB/Swiss-Prot
      P10630
      UniProtKB/TrEMBL
      Q52KC1, Q8BTU6
      Related
      ENSMUSP00000090876.4, ENSMUST00000077605.11
      Conserved Domains (1) summary
      cl26939
      Location:21360
      DEXDc; DEAD-like helicases superfamily
    3. NM_001347179.2NP_001334108.1  eukaryotic initiation factor 4A-II isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The encoded isoform (d) is longer than isoform a.
      Source sequence(s)
      AC154540
      Consensus CDS
      CCDS84218.1
      UniProtKB/Swiss-Prot
      P10630
      Conserved Domains (1) summary
      cl26939
      Location:9408
      DEXDc; DEAD-like helicases superfamily
    4. NM_013506.3NP_038534.2  eukaryotic initiation factor 4A-II isoform a

      See identical proteins and their annotated locations for NP_038534.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform a.
      Source sequence(s)
      AC154540, AK076509, BC094422, BY286182, CF723811
      Consensus CDS
      CCDS28074.1
      UniProtKB/Swiss-Prot
      P10630
      UniProtKB/TrEMBL
      Q52KC1
      Related
      ENSMUSP00000023599.6, ENSMUST00000023599.12
      Conserved Domains (1) summary
      cl26939
      Location:21407
      DEXDc; DEAD-like helicases superfamily

    RNA

    1. NR_110335.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) includes an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC154540, AK076509, AK132969, BC094422, BY286182, CF723811
    2. NR_152586.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) contains an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC154540

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000082.6 Reference GRCm38.p4 C57BL/6J

      Range
      23107402..23114132
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006521783.3XP_006521846.1  eukaryotic initiation factor 4A-II isoform X1

      Related
      ENSMUSP00000110998.3, ENSMUST00000115341.10
      Conserved Domains (1) summary
      cl26939
      Location:9408
      DEXDc; DEAD-like helicases superfamily
    2. XM_006521784.3XP_006521847.1  eukaryotic initiation factor 4A-II isoform X2

      See identical proteins and their annotated locations for XP_006521847.1

      Related
      ENSMUSP00000156170.1, ENSMUST00000232287.1
      Conserved Domains (1) summary
      cl26939
      Location:9361
      DEXDc; DEAD-like helicases superfamily
    3. XM_006521785.1XP_006521848.1  eukaryotic initiation factor 4A-II isoform X3

      See identical proteins and their annotated locations for XP_006521848.1

      UniProtKB/TrEMBL
      E9Q561
      Conserved Domains (2) summary
      cd00079
      Location:152267
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      cl21455
      Location:18141
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    4. XM_017316873.1XP_017172362.1  eukaryotic initiation factor 4A-II isoform X3

      UniProtKB/TrEMBL
      E9Q561
      Conserved Domains (2) summary
      cd00079
      Location:152267
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      cl21455
      Location:18141
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RNA

    1. XR_001781791.1 RNA Sequence

    2. XR_384524.3 RNA Sequence

    3. XR_384525.3 RNA Sequence

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