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    Eif3a eukaryotic translation initiation factor 3, subunit A [ Mus musculus (house mouse) ]

    Gene ID: 13669, updated on 31-Jan-2019

    Summary

    Official Symbol
    Eif3aprovided by MGI
    Official Full Name
    eukaryotic translation initiation factor 3, subunit Aprovided by MGI
    Primary source
    MGI:MGI:95301
    See related
    Ensembl:ENSMUSG00000024991
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Csma; Eif3; Eif3s10; mKIAA0139; A830012B05Rik
    Expression
    Broad expression in CNS E11.5 (RPKM 81.9), liver E14 (RPKM 47.8) and 23 other tissues See more
    Orthologs

    Genomic context

    See Eif3a in Genome Data Viewer
    Location:
    19; 19 D3
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 19 NC_000085.6 (60761116..60790693, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (60837019..60866596, complement)

    Chromosome 19 - NC_000085.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 34459 Neighboring gene predicted gene, 34406 Neighboring gene nanos C2HC-type zinc finger 1 Neighboring gene microRNA 3084-2 Neighboring gene small nucleolar RNA, H/ACA box 19 Neighboring gene family with sequence similarity 45, member A Neighboring gene sideroflexin 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    receptor tyrosine kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    contributes_to translation initiation factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to translation initiation factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    IRES-dependent viral translational initiation ISO
    Inferred from Sequence Orthology
    more info
     
    formation of cytoplasmic translation initiation complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    formation of cytoplasmic translation initiation complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    formation of cytoplasmic translation initiation complex ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    translation IEA
    Inferred from Electronic Annotation
    more info
     
    translation reinitiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    translational initiation IEA
    Inferred from Electronic Annotation
    more info
     
    viral translational termination-reinitiation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    eukaryotic translation initiation factor 3 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    eukaryotic translation initiation factor 3 complex ISO
    Inferred from Sequence Orthology
    more info
     
    eukaryotic translation initiation factor 3 complex, eIF3e IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    eukaryotic translation initiation factor 3 complex, eIF3m IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    eukaryotic translation initiation factor 3 complex, eIF3m IDA
    Inferred from Direct Assay
    more info
    PubMed 
    microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    multi-eIF complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    postsynaptic density EXP
    Inferred from Experiment
    more info
    PubMed 
    postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    eukaryotic translation initiation factor 3 subunit A
    Names
    EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT 10 (EIF-3 THETA) (EIF3 P167) (EIF3 P180) (EIF3 P185) (P162 PROTEIN) (CENTROSOMIN)
    centrosomin
    eIF-3-theta
    eIF3 p167
    eIF3 p180
    eIF3 p185
    eIF3a
    eukaryotic translation initiation factor 3, subunit 10 (theta)
    p162

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010123.3NP_034253.3  eukaryotic translation initiation factor 3 subunit A

      See identical proteins and their annotated locations for NP_034253.3

      Status: VALIDATED

      Source sequence(s)
      AC163019, AK013070, AK145132, AK162784, U14172
      Consensus CDS
      CCDS38035.1
      UniProtKB/Swiss-Prot
      P23116
      UniProtKB/TrEMBL
      Q3TRH1, Q3UM46
      Related
      ENSMUSP00000025955.6, ENSMUST00000025955.6
      Conserved Domains (5) summary
      smart00753
      Location:426498
      PAM; PCI/PINT associated module
      pfam05750
      Location:8821111
      Rubella_Capsid; Rubella capsid protein
      cd16269
      Location:650661
      GBP_C; coiled coil [structural motif]
      cl19219
      Location:643737
      DUF342; Protein of unknown function (DUF342)
      cl20817
      Location:566685
      GBP_C; Guanylate-binding protein, C-terminal domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000085.6 Reference GRCm38.p4 C57BL/6J

      Range
      60761116..60790693 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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