Eif2s1 eukaryotic translation initiation factor 2, subunit 1 alpha [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Eif2s1provided by MGI
Official Full Name: eukaryotic translation initiation factor 2, subunit 1 alphaprovided by MGI
Primary source: MGI:MGI:95299
See related: Ensembl:ENSMUSG00000021116 AllianceGenome:MGI:95299
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 35kDa; Eif2a; eIF2alpha; 0910001O23Rik; 2410026C18Rik
Summary: Enables translation initiation factor activity. Involved in several processes, including cellular response to amino acid starvation; negative regulation of translational initiation in response to stress; and stress granule assembly. Acts upstream of or within protein autophosphorylation; regulation of translational initiation in response to stress; and translation. Located in cytoplasmic stress granule and nucleus. Is active in synapse. Is expressed in several structures, including brain ventricular layer; jaw; nose; orbito-sphenoid; and thymus primordium. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human EIF2S1 (eukaryotic translation initiation factor 2 subunit alpha). [provided by Alliance of Genome Resources, Jul 2025]
Expression: Ubiquitous expression in placenta adult (RPKM 24.6), liver E14 (RPKM 23.2) and 26 other tissues See more
Orthologs: all
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Genomic context

Location:: 12 C3; 12 35.51 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (78908846..78933784)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (78862072..78887010)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

eIF2alpha incites photoreceptor cell and retina damage by all-trans-retinal.
Title: eIF2α incites photoreceptor cell and retina damage by all-trans-retinal.
Amyloid beta induces Fmr1-dependent translational suppression and hyposynchrony of neural activity via phosphorylation of eIF2alpha and eEF2.
Title: Amyloid beta induces Fmr1-dependent translational suppression and hyposynchrony of neural activity via phosphorylation of eIF2α and eEF2.
Cell-type-specific disruption of PERK-eIF2alpha signaling in dopaminergic neurons alters motor and cognitive function.
Title: Cell-type-specific disruption of PERK-eIF2α signaling in dopaminergic neurons alters motor and cognitive function.
The PERK/PKR-eIF2alpha Pathway Negatively Regulates Porcine Hemagglutinating Encephalomyelitis Virus Replication by Attenuating Global Protein Translation and Facilitating Stress Granule Formation.
Title: The PERK/PKR-eIF2α Pathway Negatively Regulates Porcine Hemagglutinating Encephalomyelitis Virus Replication by Attenuating Global Protein Translation and Facilitating Stress Granule Formation.
Protein Stability Buffers the Cost of Translation Attenuation following eIF2alpha Phosphorylation.
Title: Protein Stability Buffers the Cost of Translation Attenuation following eIF2α Phosphorylation.
Satellite cell expansion is mediated by P-eIF2alpha-dependent Tacc3 translation.
Title: Satellite cell expansion is mediated by P-eIF2α-dependent Tacc3 translation.
Inhibition of eIF2alpha Dephosphorylation Protects Hepatocytes from Apoptosis by Alleviating ER Stress in Acute Liver Injury.
Title: Inhibition of eIF2α Dephosphorylation Protects Hepatocytes from Apoptosis by Alleviating ER Stress in Acute Liver Injury.
eIF2alpha controls memory consolidation via excitatory and somatostatin neurons.
Title: eIF2α controls memory consolidation via excitatory and somatostatin neurons.
Reduced EGFR Level in eIF2alpha PhosphorylationDeficient Hepatocytes Is Responsible for Susceptibility to Oxidative Stress.
Title: Reduced EGFR Level in eIF2α PhosphorylationDeficient Hepatocytes Is Responsible for Susceptibility to Oxidative Stress.
The Autophagy Protein ATG16L1 Is Required for Sindbis Virus-Induced eIF2alpha Phosphorylation and Stress Granule Formation.
Title: The Autophagy Protein ATG16L1 Is Required for Sindbis Virus-Induced eIF2α Phosphorylation and Stress Granule Formation.

Submit: New GeneRIF Correction See all GeneRIFs (63)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH127504 (e-PCR)
- UniSTS:210814

Eif2a (e-PCR), detects polymorphism
- UniSTS:142978

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables IRES-mediated translation initiation factor activity	IEA Inferred from Electronic Annotation more info
enables IRES-mediated translation initiation factor activity	ISO Inferred from Sequence Orthology more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables cap-dependent translation initiation factor activity	IEA Inferred from Electronic Annotation more info
enables cap-dependent translation initiation factor activity	ISO Inferred from Sequence Orthology more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ribosome binding	IBA Inferred from Biological aspect of Ancestor more info
enables ribosome binding	IEA Inferred from Electronic Annotation more info
enables ribosome binding	ISO Inferred from Sequence Orthology more info
enables ribosome binding	ISS Inferred from Sequence or Structural Similarity more info
enables translation initiation factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables translation initiation factor activity	IDA Inferred from Direct Assay more info	PubMed
enables translation initiation factor activity	IEA Inferred from Electronic Annotation more info
enables translation initiation factor activity	ISO Inferred from Sequence Orthology more info
enables translation initiation factor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in HRI-mediated signaling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within HRI-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in HRI-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in HRI-mediated signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in PERK-mediated unfolded protein response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within PERK-mediated unfolded protein response	ISO Inferred from Sequence Orthology more info
involved_in PERK-mediated unfolded protein response	ISO Inferred from Sequence Orthology more info
involved_in PERK-mediated unfolded protein response	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to UV	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to amino acid starvation	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to chemical stress	IEA Inferred from Electronic Annotation more info
involved_in cellular response to heat	IEA Inferred from Electronic Annotation more info
involved_in cellular response to heat	ISO Inferred from Sequence Orthology more info
involved_in cellular response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mitochondrial respirasome assembly	ISO Inferred from Sequence Orthology more info
involved_in mitophagy	IEA Inferred from Electronic Annotation more info
involved_in mitophagy	ISO Inferred from Sequence Orthology more info
involved_in mitophagy	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of guanyl-nucleotide exchange factor activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of translational initiation in response to stress	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of type B pancreatic cell apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of type B pancreatic cell apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of translation	IEA Inferred from Electronic Annotation more info
involved_in regulation of translation in response to endoplasmic reticulum stress	IEA Inferred from Electronic Annotation more info
involved_in regulation of translation in response to endoplasmic reticulum stress	ISO Inferred from Sequence Orthology more info
involved_in regulation of translational initiation	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within regulation of translational initiation in response to stress	IDA Inferred from Direct Assay more info	PubMed
involved_in response to endoplasmic reticulum stress	IDA Inferred from Direct Assay more info	PubMed
involved_in response to endoplasmic reticulum stress	IEA Inferred from Electronic Annotation more info
involved_in response to endoplasmic reticulum stress	ISO Inferred from Sequence Orthology more info
involved_in response to kainic acid	IEA Inferred from Electronic Annotation more info
involved_in response to manganese-induced endoplasmic reticulum stress	IEA Inferred from Electronic Annotation more info
involved_in spermatogonial cell division	NAS Non-traceable Author Statement more info	PubMed
involved_in stress granule assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within translation	IDA Inferred from Direct Assay more info	PubMed
involved_in translation	IEA Inferred from Electronic Annotation more info
involved_in translational initiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in translational initiation	IDA Inferred from Direct Assay more info	PubMed
involved_in translational initiation	IEA Inferred from Electronic Annotation more info
involved_in translational initiation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic stress granule	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic stress granule	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
part_of eukaryotic 48S preinitiation complex	IBA Inferred from Biological aspect of Ancestor more info
part_of eukaryotic translation initiation factor 2 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of eukaryotic translation initiation factor 2 complex	IEA Inferred from Electronic Annotation more info
part_of eukaryotic translation initiation factor 2 complex	ISO Inferred from Sequence Orthology more info
part_of eukaryotic translation initiation factor 2 complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in glial limiting end-foot	IEA Inferred from Electronic Annotation more info
located_in glial limiting end-foot	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in synapse	EXP Inferred from Experiment more info	PubMed
is_active_in synapse	IDA Inferred from Direct Assay more info	PubMed
part_of translation initiation ternary complex	IEA Inferred from Electronic Annotation more info
part_of translation initiation ternary complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: eukaryotic translation initiation factor 2 subunit 1

Names: eIF-2-alpha; eIF-2A; eIF-2alpha; eIF2-alpha; eukaryotic translation initiation factor 2 subunit alpha; eukaryotic translation initiation factor 2A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_026114.3 → NP_080390.1 eukaryotic translation initiation factor 2 subunit 1

See identical proteins and their annotated locations for NP_080390.1

Status: PROVISIONAL

Source sequence(s)

AK143499

Consensus CDS

CCDS26003.1

UniProtKB/Swiss-Prot

Q3TIQ0, Q6ZWX6

Related

ENSMUSP00000071214.8, ENSMUST00000071230.8

Conserved Domains (1) summary

PTZ00248
Location:4 → 315

PTZ00248; eukaryotic translation initiation factor 2 subunit 1; Provisional