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    Eif2s1 eukaryotic translation initiation factor 2, subunit 1 alpha [ Mus musculus (house mouse) ]

    Gene ID: 13665, updated on 5-Sep-2021

    Summary

    Official Symbol
    Eif2s1provided by MGI
    Official Full Name
    eukaryotic translation initiation factor 2, subunit 1 alphaprovided by MGI
    Primary source
    MGI:MGI:95299
    See related
    Ensembl:ENSMUSG00000021116
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Eif; eIF2; 35kDa; Eif2a; eIF2alpha; 0910001O23Rik; 2410026C18Rik
    Expression
    Ubiquitous expression in placenta adult (RPKM 24.6), liver E14 (RPKM 23.2) and 26 other tissues See more
    Orthologs
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    Genomic context

    See Eif2s1 in Genome Data Viewer
    Location:
    12; 12 C3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (78908846..78933784)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (78862072..78887010)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (79963059..79987997)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene protein associated with LIN7 1, MAGUK family member Neighboring gene ATPase, H+ transporting, lysosomal V1 subunit D Neighboring gene pleckstrin 2 Neighboring gene predicted gene, 46359 Neighboring gene predicted gene, 46360

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ribosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ribosome binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables translation initiation factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in PERK-mediated unfolded protein response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in aging ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to UV IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to amino acid starvation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to heat ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of translational initiation in response to stress IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of neuron death ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of type B pancreatic cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within regulation of translation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within regulation of translational initiation in response to stress IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to endoplasmic reticulum stress IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to endoplasmic reticulum stress ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in stress granule assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within translation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within translational initiation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic stress granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    part_of eukaryotic 48S preinitiation complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of eukaryotic translation initiation factor 2 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of eukaryotic translation initiation factor 2 complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of eukaryotic translation initiation factor 2B complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of eukaryotic translation initiation factor 2B complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in glial limiting end-foot ISO
    Inferred from Sequence Orthology
    more info
     
    part_of multi-eIF complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in synapse EXP
    Inferred from Experiment
    more info
    PubMed 
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of translation initiation ternary complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    eukaryotic translation initiation factor 2 subunit 1
    Names
    eIF-2-alpha
    eIF-2A
    eIF-2alpha
    eukaryotic translation initiation factor 2 subunit alpha
    eukaryotic translation initiation factor 2A

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026114.3NP_080390.1  eukaryotic translation initiation factor 2 subunit 1

      See identical proteins and their annotated locations for NP_080390.1

      Status: PROVISIONAL

      Source sequence(s)
      AK143499
      Consensus CDS
      CCDS26003.1
      UniProtKB/Swiss-Prot
      Q6ZWX6
      Related
      ENSMUSP00000071214.8, ENSMUST00000071230.8
      Conserved Domains (1) summary
      PTZ00248
      Location:4315
      PTZ00248; eukaryotic translation initiation factor 2 subunit 1; Provisional

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      78908846..78933784
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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