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    Ei24 etoposide induced 2.4 mRNA [ Mus musculus (house mouse) ]

    Gene ID: 13663, updated on 31-Jan-2019

    Summary

    Official Symbol
    Ei24provided by MGI
    Official Full Name
    etoposide induced 2.4 mRNAprovided by MGI
    Primary source
    MGI:MGI:108090
    See related
    Ensembl:ENSMUSG00000062762
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PIG8; AA536736; AI115355
    Expression
    Ubiquitous expression in liver adult (RPKM 47.4), bladder adult (RPKM 40.3) and 28 other tissues See more
    Orthologs

    Genomic context

    See Ei24 in Genome Data Viewer
    Location:
    9 A4; 9 20.68 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 9 NC_000075.6 (36779153..36797393, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (36586740..36604653, complement)

    Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene checkpoint kinase 1 Neighboring gene STT3, subunit of the oligosaccharyltransferase complex, homolog A (S. cerevisiae) Neighboring gene predicted gene, 26787 Neighboring gene predicted gene 27219 Neighboring gene fasciculation and elongation protein zeta 1 (zygin I) Neighboring gene Pbx/knotted 1 homeobox 2 Neighboring gene predicted gene, 34652

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    • p53 signaling, organism-specific biosystem (from WikiPathways)
      p53 signaling, organism-specific biosystemhttp://www.kegg.jp/ (mmu04115) p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcription...
    • p53 signaling pathway, organism-specific biosystem (from KEGG)
      p53 signaling pathway, organism-specific biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...
    • p53 signaling pathway, conserved biosystem (from KEGG)
      p53 signaling pathway, conserved biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    importin-alpha family protein binding IMP
    Inferred from Mutant Phenotype
    more info
     
    Process Evidence Code Pubs
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    autophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to UV-C IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    intrinsic apoptotic signaling pathway in response to DNA damage IDA
    Inferred from Direct Assay
    more info
    PubMed 
    macroautophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of cell growth ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    negative regulation of protein import into nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuromuscular process controlling balance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of intrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to drug IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    etoposide-induced protein 2.4
    Names
    p53-induced gene 8 protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001199494.1NP_001186423.1  etoposide-induced protein 2.4

      See identical proteins and their annotated locations for NP_001186423.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK159927, BU148129, BY282890, CD645143
      Consensus CDS
      CCDS22973.1
      UniProtKB/Swiss-Prot
      Q61070
      UniProtKB/TrEMBL
      A0A0R4J250
      Related
      ENSMUSP00000110738.4, ENSMUST00000115086.12
      Conserved Domains (1) summary
      pfam07264
      Location:138272
      EI24; Etoposide-induced protein 2.4 (EI24)
    2. NM_007915.5NP_031941.1  etoposide-induced protein 2.4

      See identical proteins and their annotated locations for NP_031941.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains a different segment for its 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC155921, CD645143, U41751
      Consensus CDS
      CCDS22973.1
      UniProtKB/Swiss-Prot
      Q61070
      UniProtKB/TrEMBL
      A0A0R4J250
      Related
      ENSMUSP00000132270.2, ENSMUST00000163192.9
      Conserved Domains (1) summary
      pfam07264
      Location:138272
      EI24; Etoposide-induced protein 2.4 (EI24)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000075.6 Reference GRCm38.p4 C57BL/6J

      Range
      36779153..36797393 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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