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    Efnb2 ephrin B2 [ Mus musculus (house mouse) ]

    Gene ID: 13642, updated on 5-Mar-2019

    Summary

    Official Symbol
    Efnb2provided by MGI
    Official Full Name
    ephrin B2provided by MGI
    Primary source
    MGI:MGI:105097
    See related
    Ensembl:ENSMUSG00000001300
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Epl5; ELF-2; Eplg5; Htk-L; Lerk5; LERK-5; NLERK-1
    Expression
    Broad expression in lung adult (RPKM 20.3), colon adult (RPKM 11.2) and 23 other tissues See more
    Orthologs

    Genomic context

    See Efnb2 in Genome Data Viewer
    Location:
    8 A1.1; 8 3.42 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 8 NC_000074.6 (8617235..8661260, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (8617439..8660773, complement)

    Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 31135 Neighboring gene peroxiredoxin 3 pseudogene Neighboring gene predicted gene, 31463 Neighboring gene arginine and glutamate rich 1 Neighboring gene microRNA 7654 Neighboring gene IKAROS family zinc finger 5 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ephrin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ephrin receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    signaling receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    T cell costimulation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    animal organ morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    blood vessel morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    blood vessel morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    cell migration involved in sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    ephrin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ephrin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    lymph vessel development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of keratinocyte proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    nephric duct morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    nervous system development IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of aorta morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cardiac muscle cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of neuron death ISO
    Inferred from Sequence Orthology
    more info
     
    presynapse assembly ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of postsynaptic membrane neurotransmitter receptor levels IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of postsynaptic membrane neurotransmitter receptor levels IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of postsynaptic neurotransmitter receptor internalization EXP
    Inferred from Experiment
    more info
    PubMed 
    regulation of postsynaptic neurotransmitter receptor internalization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of postsynaptic neurotransmitter receptor internalization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    venous blood vessel morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    Schaffer collateral - CA1 synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Schaffer collateral - CA1 synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    glutamatergic synapse EXP
    Inferred from Experiment
    more info
    PubMed 
    glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of postsynaptic density membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of presynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ephrin-B2
    Names
    EPH-related receptor tyrosine kinase ligand 5
    HTK ligand

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001368299.1NP_001355228.1  ephrin-B2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC138368, AC161867
    2. NM_010111.6NP_034241.2  ephrin-B2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_034241.2

      Status: VALIDATED

      Source sequence(s)
      AC138368, AC161867
      Consensus CDS
      CCDS22090.1
      UniProtKB/Swiss-Prot
      P52800
      UniProtKB/TrEMBL
      Q4FJM3
      Related
      ENSMUSP00000001319.7, ENSMUST00000001319.14
      Conserved Domains (1) summary
      cd10426
      Location:32168
      Ephrin-B_Ectodomain; Ectodomain of Ephrin B

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000074.6 Reference GRCm38.p4 C57BL/6J

      Range
      8617235..8661260 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006508694.3XP_006508757.1  ephrin-B2 isoform X2

      Conserved Domains (1) summary
      cl19115
      Location:32145
      Cupredoxin; Cupredoxin superfamily
    2. XM_011242036.2XP_011240338.1  ephrin-B2 isoform X1

      Conserved Domains (1) summary
      cd10426
      Location:44168
      Ephrin-B_Ectodomain; Ectodomain of Ephrin B
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