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    Eef2k eukaryotic elongation factor-2 kinase [ Mus musculus (house mouse) ]

    Gene ID: 13631, updated on 27-Jul-2021

    Summary

    Official Symbol
    Eef2kprovided by MGI
    Official Full Name
    eukaryotic elongation factor-2 kinaseprovided by MGI
    Primary source
    MGI:MGI:1195261
    See related
    Ensembl:ENSMUSG00000035064
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C86191; eEF-2K
    Expression
    Ubiquitous expression in bladder adult (RPKM 19.4), colon adult (RPKM 10.7) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Eef2k in Genome Data Viewer
    Location:
    7; 7 F2
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (120441961..120506442)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (120842642..120907219)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (127986397..128047515)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene 5737 Neighboring gene nuclear encoded tRNA leucine 1 (anticodon TAG) Neighboring gene predicted gene, 36449 Neighboring gene predicted gene 15774 Neighboring gene nuclear encoded tRNA leucine 4 (anticodon AAG) Neighboring gene polymerase (RNA) III (DNA directed) polypeptide E

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables calmodulin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables calmodulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables elongation factor-2 kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables elongation factor-2 kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables translation factor activity, RNA binding TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in dendritic spine ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    eukaryotic elongation factor 2 kinase
    Names
    calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase
    eEF-2 kinase
    eukaroytic elongation factor 2 kinase
    NP_001254639.1
    NP_001254640.1
    NP_031934.1
    XP_006507405.1
    XP_006507406.1
    XP_006507407.1
    XP_006507408.1
    XP_036008548.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001267710.1NP_001254639.1  eukaryotic elongation factor 2 kinase

      See identical proteins and their annotated locations for NP_001254639.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC122248, AI842850, AK080915
      Consensus CDS
      CCDS21796.1
      UniProtKB/Swiss-Prot
      O08796
      UniProtKB/TrEMBL
      Q8BNP6
      Related
      ENSMUSP00000102098.2, ENSMUST00000106489.9
      Conserved Domains (3) summary
      COG0790
      Location:492688
      TPR; TPR repeat [Signal transduction mechanisms]
      sd00010
      Location:502535
      SLR; SLR repeat [structural motif]
      cd16967
      Location:102317
      Alpha_kinase_eEF2K; Alpha-kinase domain of eukaryotic elongation factor-2 kinase
    2. NM_001267711.1NP_001254640.1  eukaryotic elongation factor 2 kinase

      See identical proteins and their annotated locations for NP_001254640.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC122248, AI842850, BC055361, CJ052887
      Consensus CDS
      CCDS21796.1
      UniProtKB/Swiss-Prot
      O08796
      UniProtKB/TrEMBL
      Q7TPC7
      Related
      ENSMUSP00000102097.2, ENSMUST00000106488.3
      Conserved Domains (3) summary
      COG0790
      Location:492688
      TPR; TPR repeat [Signal transduction mechanisms]
      sd00010
      Location:502535
      SLR; SLR repeat [structural motif]
      cd16967
      Location:102317
      Alpha_kinase_eEF2K; Alpha-kinase domain of eukaryotic elongation factor-2 kinase
    3. NM_007908.4NP_031934.1  eukaryotic elongation factor 2 kinase

      See identical proteins and their annotated locations for NP_031934.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the functional protein. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC122214, AC122248, AI842850, AK028524
      Consensus CDS
      CCDS21796.1
      UniProtKB/Swiss-Prot
      O08796
      UniProtKB/TrEMBL
      Q8CEC8
      Related
      ENSMUSP00000046595.9, ENSMUST00000047875.16
      Conserved Domains (3) summary
      COG0790
      Location:492688
      TPR; TPR repeat [Signal transduction mechanisms]
      sd00010
      Location:502535
      SLR; SLR repeat [structural motif]
      cd16967
      Location:102317
      Alpha_kinase_eEF2K; Alpha-kinase domain of eukaryotic elongation factor-2 kinase

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      120441961..120506442
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006507344.5XP_006507407.1  eukaryotic elongation factor 2 kinase isoform X2

      Conserved Domains (3) summary
      COG0790
      Location:500600
      TPR; TPR repeat [Signal transduction mechanisms]
      sd00010
      Location:497530
      SLR; SLR repeat [structural motif]
      cd16967
      Location:102317
      Alpha_kinase_eEF2K; Alpha-kinase domain of eukaryotic elongation factor-2 kinase
    2. XM_006507345.5XP_006507408.1  eukaryotic elongation factor 2 kinase isoform X3

      See identical proteins and their annotated locations for XP_006507408.1

      Conserved Domains (2) summary
      sd00010
      Location:484513
      SLR; SLR repeat [structural motif]
      cd16967
      Location:102317
      Alpha_kinase_eEF2K; Alpha-kinase domain of eukaryotic elongation factor-2 kinase
    3. XM_006507342.4XP_006507405.1  eukaryotic elongation factor 2 kinase isoform X1

      See identical proteins and their annotated locations for XP_006507405.1

      UniProtKB/Swiss-Prot
      O08796
      Conserved Domains (3) summary
      COG0790
      Location:492688
      TPR; TPR repeat [Signal transduction mechanisms]
      sd00010
      Location:502535
      SLR; SLR repeat [structural motif]
      cd16967
      Location:102317
      Alpha_kinase_eEF2K; Alpha-kinase domain of eukaryotic elongation factor-2 kinase
    4. XM_006507343.4XP_006507406.1  eukaryotic elongation factor 2 kinase isoform X1

      See identical proteins and their annotated locations for XP_006507406.1

      UniProtKB/Swiss-Prot
      O08796
      Conserved Domains (3) summary
      COG0790
      Location:492688
      TPR; TPR repeat [Signal transduction mechanisms]
      sd00010
      Location:502535
      SLR; SLR repeat [structural motif]
      cd16967
      Location:102317
      Alpha_kinase_eEF2K; Alpha-kinase domain of eukaryotic elongation factor-2 kinase
    5. XM_036152655.1XP_036008548.1  eukaryotic elongation factor 2 kinase isoform X4

      Conserved Domains (3) summary
      COG0790
      Location:351547
      TPR; TPR repeat [Signal transduction mechanisms]
      sd00010
      Location:361394
      SLR; SLR repeat [structural motif]
      cd16967
      Location:1176
      Alpha_kinase_eEF2K; Alpha-kinase domain of eukaryotic elongation factor-2 kinase

    RNA

    1. XR_003946386.2 RNA Sequence

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