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    Eef2 eukaryotic translation elongation factor 2 [ Mus musculus (house mouse) ]

    Gene ID: 13629, updated on 31-Jan-2019

    Summary

    Official Symbol
    Eef2provided by MGI
    Official Full Name
    eukaryotic translation elongation factor 2provided by MGI
    Primary source
    MGI:MGI:95288
    See related
    Ensembl:ENSMUSG00000034994
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ef-2
    Expression
    Ubiquitous expression in ovary adult (RPKM 1248.0), colon adult (RPKM 810.0) and 28 other tissues See more
    Orthologs

    Genomic context

    See Eef2 in Genome Data Viewer
    Location:
    10; 10 C1
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 10 NC_000076.6 (81176631..81182509)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (80639376..80645254)

    Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene zinc finger and BTB domain containing 7a Neighboring gene protein inhibitor of activated STAT 4 Neighboring gene small nucleolar RNA, C/D box 37 Neighboring gene death-associated protein kinase 3 Neighboring gene ataxia, cerebellar, Cayman type, opposite strand Neighboring gene nicotinamide riboside kinase 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC98463

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    5S rRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    GTPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    actin filament binding ISO
    Inferred from Sequence Orthology
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    p53 binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    ribosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ribosome binding ISO
    Inferred from Sequence Orthology
    more info
     
    translation elongation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    hematopoietic progenitor cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cytoplasmic translation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of translation ISO
    Inferred from Sequence Orthology
    more info
     
    translation IEA
    Inferred from Electronic Annotation
    more info
     
    translational elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    translational elongation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    aggresome ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    NOT nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    polysomal ribosome ISO
    Inferred from Sequence Orthology
    more info
     
    polysome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    synapse EXP
    Inferred from Experiment
    more info
    PubMed 
    synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007907.2NP_031933.1  elongation factor 2

      See identical proteins and their annotated locations for NP_031933.1

      Status: VALIDATED

      Source sequence(s)
      AK168794, CJ170931, CJ316208
      Consensus CDS
      CCDS35993.1
      UniProtKB/Swiss-Prot
      P58252
      Related
      ENSMUSP00000046101.9, ENSMUST00000047864.10
      Conserved Domains (6) summary
      cd01885
      Location:20233
      EF2; Elongation Factor 2 (EF2) in archaea and eukarya
      cd01681
      Location:574746
      aeEF2_snRNP_like_IV; This family represents domain IV of archaeal and eukaryotic elongation factor 2 (aeEF-2) and of an evolutionarily conserved U5 snRNP-specific protein. U5 snRNP is a GTP-binding factor closely related to the ribosomal translocase EF-2. In complex with GTP, ...
      cd04096
      Location:742821
      eEF2_snRNP_like_C; eEF2_snRNP_like_C: this family represents a C-terminal domain of eukaryotic elongation factor 2 (eEF-2) and a homologous domain of the spliceosomal human 116kD U5 small nuclear ribonucleoprotein (snRNP) protein (U5-116 kD) and, its yeast counterpart ...
      PTZ00416
      Location:1858
      PTZ00416; elongation factor 2; Provisional
      cd03700
      Location:394488
      EF2_snRNP_like_II; Domain II of elongation factor 2 and C-terminal domain of the spliceosomal human 116kD U5 small nuclear ribonucleoprotein (snRNP) protein
      cd16261
      Location:503574
      EF2_snRNP_III; Domain III of Elongation Factor 2 (EF2)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000076.6 Reference GRCm38.p4 C57BL/6J

      Range
      81176631..81182509
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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