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    Eed embryonic ectoderm development [ Mus musculus (house mouse) ]

    Gene ID: 13626, updated on 5-Sep-2021

    Summary

    Official Symbol
    Eedprovided by MGI
    Official Full Name
    embryonic ectoderm developmentprovided by MGI
    Primary source
    MGI:MGI:95286
    See related
    Ensembl:ENSMUSG00000030619
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    l7; l(7); lusk; l7Rn5; l(7)5Rn
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 15.5), liver E14 (RPKM 11.6) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Eed in Genome Data Viewer
    Location:
    7 D3; 7
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (89603862..89630184, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (89954654..89980976, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (97103164..97129486, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 81 Neighboring gene heat shock protein nuclear import factor Neighboring gene Eed upstream regulatory region Neighboring gene RIKEN cDNA E230029C05 gene Neighboring gene predicted gene, 32164 Neighboring gene basic transcription factor 3, pseudogene 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables enzyme activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to histone methyltransferase activity (H3-K27 specific) IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to nucleosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription corepressor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of ESC/E(Z) complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of ESC/E(Z) complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of ESC/E(Z) complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of chromatin silencing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in pronucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in sex chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    polycomb protein EED
    Names
    lethal, Chr 7, Rinchik 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021876.3NP_068676.1  polycomb protein EED

      See identical proteins and their annotated locations for NP_068676.1

      Status: VALIDATED

      Source sequence(s)
      AK131976, BQ899891, CJ200028, U97675
      Consensus CDS
      CCDS40016.1
      UniProtKB/Swiss-Prot
      Q921E6
      Related
      ENSMUSP00000159149.2, ENSMUST00000238981.2
      Conserved Domains (2) summary
      sd00039
      Location:96140
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:150438
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      89603862..89630184 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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