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    Ect2 ect2 oncogene [ Mus musculus (house mouse) ]

    Gene ID: 13605, updated on 31-Jan-2019

    Summary

    Official Symbol
    Ect2provided by MGI
    Official Full Name
    ect2 oncogeneprovided by MGI
    Primary source
    MGI:MGI:95281
    See related
    Ensembl:ENSMUSG00000027699
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI528536
    Expression
    Biased expression in CNS E11.5 (RPKM 13.0), liver E14 (RPKM 11.1) and 12 other tissues See more
    Orthologs

    Genomic context

    See Ect2 in Genome Data Viewer
    Location:
    3; 3 A3
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 3 NC_000069.6 (27097222..27153909, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (26996144..27052800, complement)

    Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene spermatogenesis associated 16 Neighboring gene predicted gene, 32458 Neighboring gene ribosomal protein L3 pseudogene Neighboring gene RIKEN cDNA 1700125G22 gene Neighboring gene neutral cholesterol ester hydrolase 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA4037

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    Rho GTPase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Rho guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    activation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    activation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    bicellular tight junction assembly ISO
    Inferred from Sequence Orthology
    more info
     
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    cell morphogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to calcium ion ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to hydrogen peroxide ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to ionizing radiation ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    mitotic cytokinesis ISO
    Inferred from Sequence Orthology
    more info
     
    nervous system development IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cytokinesis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein import into nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein homooligomerization ISO
    Inferred from Sequence Orthology
    more info
     
    protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of Rho protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of attachment of spindle microtubules to kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cytokinesis, actomyosin contractile ring assembly IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    bicellular tight junction ISO
    Inferred from Sequence Orthology
    more info
     
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    centralspindlin complex ISO
    Inferred from Sequence Orthology
    more info
     
    cleavage furrow ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    midbody ISO
    Inferred from Sequence Orthology
    more info
     
    mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    protein ECT2
    Names
    epithelial cell-transforming sequence 2 oncogene

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001177625.1NP_001171096.1  protein ECT2 isoform 2

      See identical proteins and their annotated locations for NP_001171096.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) is missing an in-frame coding exon compared to variant 1, resulting in a shorter isoform (2) lacking an internal protein segment compared to isoform 1. Variants 2 and 3 encode the same isoform.
      Source sequence(s)
      AK157718, CN702302
      Consensus CDS
      CCDS50875.1
      UniProtKB/Swiss-Prot
      Q07139
      Related
      ENSMUSP00000135740.2, ENSMUST00000176242.8
      Conserved Domains (4) summary
      cd01229
      Location:600773
      PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
      pfam00533
      Location:235310
      BRCT; BRCA1 C Terminus (BRCT) domain
      pfam00621
      Location:425609
      RhoGEF; RhoGEF domain
      pfam12738
      Location:148211
      PTCB-BRCT; twin BRCT domain
    2. NM_001177626.1NP_001171097.1  protein ECT2 isoform 2

      See identical proteins and their annotated locations for NP_001171097.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate donor splice site at the 5' terminal non-coding exon, and is missing an in-frame coding exon compared to variant 1, resulting in a shorter isoform (2) lacking an internal protein segment compared to isoform 1. Variants 2 and 3 encode the same isoform.
      Source sequence(s)
      AK157718, BY070590
      Consensus CDS
      CCDS50875.1
      UniProtKB/Swiss-Prot
      Q07139
      Related
      ENSMUSP00000103933.2, ENSMUST00000108298.8
      Conserved Domains (4) summary
      cd01229
      Location:600773
      PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
      pfam00533
      Location:235310
      BRCT; BRCA1 C Terminus (BRCT) domain
      pfam00621
      Location:425609
      RhoGEF; RhoGEF domain
      pfam12738
      Location:148211
      PTCB-BRCT; twin BRCT domain
    3. NM_007900.3NP_031926.2  protein ECT2 isoform 1

      See identical proteins and their annotated locations for NP_031926.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK157718, CF735294, CN702302
      Consensus CDS
      CCDS17270.2
      UniProtKB/Swiss-Prot
      Q07139
      Related
      ENSMUSP00000103935.1, ENSMUST00000108300.7
      Conserved Domains (4) summary
      cd01229
      Location:631804
      PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
      pfam00533
      Location:266341
      BRCT; BRCA1 C Terminus (BRCT) domain
      pfam00621
      Location:456640
      RhoGEF; RhoGEF domain
      pfam12738
      Location:179242
      PTCB-BRCT; twin BRCT domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000069.6 Reference GRCm38.p4 C57BL/6J

      Range
      27097222..27153909 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006535385.3XP_006535448.1  protein ECT2 isoform X1

      See identical proteins and their annotated locations for XP_006535448.1

      UniProtKB/Swiss-Prot
      Q07139
      Conserved Domains (4) summary
      cd01229
      Location:631804
      PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
      pfam00533
      Location:266341
      BRCT; BRCA1 C Terminus (BRCT) domain
      pfam00621
      Location:456640
      RhoGEF; RhoGEF domain
      pfam12738
      Location:179242
      PTCB-BRCT; twin BRCT domain
    2. XM_006535386.3XP_006535449.1  protein ECT2 isoform X1

      See identical proteins and their annotated locations for XP_006535449.1

      UniProtKB/Swiss-Prot
      Q07139
      Conserved Domains (4) summary
      cd01229
      Location:631804
      PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
      pfam00533
      Location:266341
      BRCT; BRCA1 C Terminus (BRCT) domain
      pfam00621
      Location:456640
      RhoGEF; RhoGEF domain
      pfam12738
      Location:179242
      PTCB-BRCT; twin BRCT domain
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