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    TMEM139 transmembrane protein 139 [ Homo sapiens (human) ]

    Gene ID: 135932, updated on 17-Sep-2024

    Summary

    Official Symbol
    TMEM139provided by HGNC
    Official Full Name
    transmembrane protein 139provided by HGNC
    Primary source
    HGNC:HGNC:22058
    See related
    Ensembl:ENSG00000178826 MIM:616524; AllianceGenome:HGNC:22058
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in kidney (RPKM 17.4), duodenum (RPKM 16.7) and 15 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See TMEM139 in Genome Data Viewer
    Location:
    7q34
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (143284899..143288049)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (144640307..144643457)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (142981992..142985142)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375546 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:142943994-142944170 Neighboring gene TMEM139 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18719 Neighboring gene Sharpr-MPRA regulatory region 7901 Neighboring gene glutathione S-transferase kappa 1 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr7:142982077-142983276 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18720 Neighboring gene RNA, 7SL, cytoplasmic 535, pseudogene Neighboring gene caspase 2 Neighboring gene RNA, 7SL, cytoplasmic 481, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Potential readthrough

    Included gene: CASP2

    Clone Names

    • FLJ90586

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001242773.2NP_001229702.1  transmembrane protein 139 precursor

      See identical proteins and their annotated locations for NP_001229702.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 8, and 9 encode the same protein.
      Source sequence(s)
      AK315170, BC035517, CB241413, HY180523
      Consensus CDS
      CCDS5878.1
      UniProtKB/Swiss-Prot
      B2RCL5, D3DXD4, Q6ZME2, Q8IV31, Q8NC22, Q96AU8
      Related
      ENSP00000386335.1, ENST00000409244.5
    2. NM_001242774.3NP_001229703.1  transmembrane protein 139 precursor

      See identical proteins and their annotated locations for NP_001229703.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 8, and 9 encode the same protein.
      Source sequence(s)
      AC073342, AK172816, BC035517
      Consensus CDS
      CCDS5878.1
      UniProtKB/Swiss-Prot
      B2RCL5, D3DXD4, Q6ZME2, Q8IV31, Q8NC22, Q96AU8
      Related
      ENSP00000386564.1, ENST00000410004.1
    3. NM_001242775.3NP_001229704.1  transmembrane protein 139 precursor

      See identical proteins and their annotated locations for NP_001229704.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 8, and 9 encode the same protein.
      Source sequence(s)
      BC035517, DA626625, HY180523
      Consensus CDS
      CCDS5878.1
      UniProtKB/Swiss-Prot
      B2RCL5, D3DXD4, Q6ZME2, Q8IV31, Q8NC22, Q96AU8
    4. NM_001282876.2NP_001269805.1  transmembrane protein 139 precursor

      See identical proteins and their annotated locations for NP_001269805.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 8, and 9 encode the same protein.
      Source sequence(s)
      BC035517, DA628164
      Consensus CDS
      CCDS5878.1
      UniProtKB/Swiss-Prot
      B2RCL5, D3DXD4, Q6ZME2, Q8IV31, Q8NC22, Q96AU8
      Related
      ENSP00000352284.3, ENST00000359333.8
    5. NM_001282877.1NP_001269806.1  transmembrane protein 139 precursor

      See identical proteins and their annotated locations for NP_001269806.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 8, and 9 encode the same protein.
      Source sequence(s)
      BC035517, CB241413, HY180523
      Consensus CDS
      CCDS5878.1
      UniProtKB/Swiss-Prot
      B2RCL5, D3DXD4, Q6ZME2, Q8IV31, Q8NC22, Q96AU8
    6. NM_153345.3NP_699176.1  transmembrane protein 139 precursor

      See identical proteins and their annotated locations for NP_699176.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the functional protein. Variants 1, 2, 3, 4, 8, and 9 encode the same protein.
      Source sequence(s)
      AK075067, BC035517, CB241413, HY180523
      Consensus CDS
      CCDS5878.1
      UniProtKB/Swiss-Prot
      B2RCL5, D3DXD4, Q6ZME2, Q8IV31, Q8NC22, Q96AU8
      Related
      ENSP00000387044.1, ENST00000409541.5

    RNA

    1. NR_040003.3 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) uses an alternate 5' exon structure, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
      Source sequence(s)
      BC035517, BE018738, DA839855
      Related
      ENST00000471161.1
    2. NR_104250.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) uses an alternate 5' exon structure, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
      Source sequence(s)
      BC035517, CB142336, CB241413, HY180523
    3. NR_104251.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) uses an alternate 5' exon structure, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
      Source sequence(s)
      BC035517, CB241413, DT220400, HY180523
    4. NR_104252.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (10) uses an alternate 5' exon structure, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
      Source sequence(s)
      BC035517, BF036500, CB241413, DB222115, HY180523
    5. NR_104253.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (11) uses an alternate 5' exon structure, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
      Source sequence(s)
      BC035517, BI761527, CB156055, HY180523
    6. NR_104254.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (12) uses an alternate 5' exon structure, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
      Source sequence(s)
      BC035517, BE562464, HY180523, R69052

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      143284899..143288049
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      144640307..144643457
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)