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    Mapre1 microtubule-associated protein, RP/EB family, member 1 [ Mus musculus (house mouse) ]

    Gene ID: 13589, updated on 14-Sep-2021

    Summary

    Official Symbol
    Mapre1provided by MGI
    Official Full Name
    microtubule-associated protein, RP/EB family, member 1provided by MGI
    Primary source
    MGI:MGI:891995
    See related
    Ensembl:ENSMUSG00000027479
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    BIM; Eb1; BIM1p; AI462499; AI504412; AW260097; D2Ertd459; D2Ertd459e; 5530600P05Rik
    Expression
    Broad expression in CNS E18 (RPKM 22.9), CNS E11.5 (RPKM 21.4) and 27 other tissues See more
    Orthologs
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    Genomic context

    See Mapre1 in Genome Data Viewer
    Location:
    2 H1; 2 75.95 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (153583131..153615237)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (153741287..153773317)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (153567023..153599053)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene DNA methyltransferase 3B, pseudogene 1 Neighboring gene sorting nexin 2 pseudogene Neighboring gene EF-hand calcium binding domain 8 Neighboring gene translocase of outer mitochondrial membrane 20 homolog pseudogene Neighboring gene Sad1 and UNC84 domain containing 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables microtubule plus-end binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables microtubule plus-end binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables microtubule plus-end binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in microtubule bundle formation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in microtubule polymerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of microtubule polymerization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within non-motile cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of microtubule plus-end binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of microtubule plus-end binding IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of microtubule polymerization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein localization to centrosome IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within protein localization to microtubule IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein localization to microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to microtubule plus-end IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of microtubule polymerization or depolymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in spindle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell projection membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in ciliary basal body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cortical microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasmic microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microtubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microtubule cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in microtubule organizing center IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in microtubule plus-end IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in microtubule plus-end IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitotic spindle astral microtubule end ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with spindle ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in spindle midzone IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    microtubule-associated protein RP/EB family member 1
    Names
    APC-binding protein EB1
    adenomatosis polyposis coli binding protein Eb1
    end-binding protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007896.3NP_031922.1  microtubule-associated protein RP/EB family member 1

      See identical proteins and their annotated locations for NP_031922.1

      Status: VALIDATED

      Source sequence(s)
      AL833803, BC043333
      Consensus CDS
      CCDS16917.1
      UniProtKB/Swiss-Prot
      Q61166
      UniProtKB/TrEMBL
      Q3U4H0
      Related
      ENSMUSP00000028981.9, ENSMUST00000028981.9
      Conserved Domains (1) summary
      COG5217
      Location:16257
      BIM1; Microtubule-binding protein involved in cell cycle control [Cell division and chromosome partitioning / Cytoskeleton]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      153583131..153615237
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036158139.1XP_036014032.1  microtubule-associated protein RP/EB family member 1 isoform X2

      Conserved Domains (1) summary
      COG5217
      Location:16160
      BIM1; Microtubule-binding protein involved in cell cycle control [Cell division and chromosome partitioning / Cytoskeleton]
    2. XM_036158136.1XP_036014029.1  microtubule-associated protein RP/EB family member 1 isoform X1

      Conserved Domains (1) summary
      COG5217
      Location:16257
      BIM1; Microtubule-binding protein involved in cell cycle control [Cell division and chromosome partitioning / Cytoskeleton]
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