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    CPA1 carboxypeptidase A1 [ Homo sapiens (human) ]

    Gene ID: 1357, updated on 11-Jun-2021

    Summary

    Official Symbol
    CPA1provided by HGNC
    Official Full Name
    carboxypeptidase A1provided by HGNC
    Primary source
    HGNC:HGNC:2296
    See related
    Ensembl:ENSG00000091704 MIM:114850
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CPA
    Summary
    This gene encodes a member of the carboxypeptidase A family of zinc metalloproteases. This enzyme is produced in the pancreas and preferentially cleaves C-terminal branched-chain and aromatic amino acids from dietary proteins. This gene and several family members are present in a gene cluster on chromosome 7. Mutations in this gene may be linked to chronic pancreatitis, while elevated protein levels may be associated with pancreatic cancer. [provided by RefSeq, Jan 2015]
    Expression
    Restricted expression toward pancreas (RPKM 26661.6) See more
    Orthologs
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    Genomic context

    See CPA1 in Genome Data Viewer
    Location:
    7q32.2
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (130380494..130388108)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (130020335..130027949)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene carboxypeptidase A4 Neighboring gene uncharacterized LOC105375503 Neighboring gene carboxypeptidase A5 Neighboring gene uncharacterized LOC105375504 Neighboring gene centrosomal protein 41 Neighboring gene uncharacterized LOC105375505

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metallocarboxypeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in leukotriene metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    carboxypeptidase A1
    Names
    carboxypeptidase A1 (pancreatic)
    pancreatic carboxypeptidase A
    NP_001859.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_042276.1 RefSeqGene

      Range
      5124..12738
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001868.4NP_001859.1  carboxypeptidase A1 preproprotein

      See identical proteins and their annotated locations for NP_001859.1

      Status: REVIEWED

      Source sequence(s)
      AK291493, X67318
      Consensus CDS
      CCDS5820.1
      UniProtKB/Swiss-Prot
      P15085
      Related
      ENSP00000011292.3, ENST00000011292.8
      Conserved Domains (2) summary
      cd03870
      Location:117417
      M14_CPA; Peptidase M14 carboxypeptidase subfamily A/B-like; Carboxypeptidase A subgroup
      pfam02244
      Location:26100
      Propep_M14; Carboxypeptidase activation peptide

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

      Range
      130380494..130388108
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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